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    GLCCI1 glucocorticoid induced 1 [ Homo sapiens (human) ]

    Gene ID: 113263, updated on 23-Mar-2024

    Summary

    Official Symbol
    GLCCI1provided by HGNC
    Official Full Name
    glucocorticoid induced 1provided by HGNC
    Primary source
    HGNC:HGNC:18713
    See related
    Ensembl:ENSG00000106415 MIM:614283; AllianceGenome:HGNC:18713
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GCTR; GIG18; TSSN1; FAM117C
    Summary
    This gene encodes a protein of unknown function. Expression of this gene is induced by glucocorticoids and may be an early marker for glucocorticoid-induced apoptosis. Single nucleotide polymorphisms in this gene are associated with a decreased response to inhaled glucocorticoids in asthmatic patients. [provided by RefSeq, Feb 2012]
    Expression
    Broad expression in thyroid (RPKM 12.0), testis (RPKM 9.8) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See GLCCI1 in Genome Data Viewer
    Location:
    7p21.3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (7968796..8089080)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (8087312..8207580)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (8008427..8128710)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901586 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25650 Neighboring gene cyclin B2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25651 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25652 Neighboring gene GLCCI1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17967 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17968 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17969 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25653 Neighboring gene peptidylprolyl isomerase like 4 pseudogene Neighboring gene MPRA-validated peak6363 silencer Neighboring gene uncharacterized LOC105375142 Neighboring gene NANOG hESC enhancer GRCh37_chr7:8144287-8144833 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25654 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25655 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:8164462-8165254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17970 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25656 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25657 Neighboring gene NANOG hESC enhancer GRCh37_chr7:8186642-8187159 Neighboring gene islet cell autoantigen 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25658 Neighboring gene uncharacterized LOC124901587 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr7:8254569-8255768

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Glucocorticoid therapy, response to
    MedGen: C3280689 OMIM: 614400 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus.
    EBI GWAS Catalog
    Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: UMAD1

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    glucocorticoid-induced transcript 1 protein
    Names
    glucocorticoid induced transcript 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032073.2 RefSeqGene

      Range
      5002..125286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138426.4NP_612435.1  glucocorticoid-induced transcript 1 protein

      See identical proteins and their annotated locations for NP_612435.1

      Status: REVIEWED

      Source sequence(s)
      AL832860, AL833694, BC050291
      Consensus CDS
      CCDS34601.1
      UniProtKB/Swiss-Prot
      A4D103, Q86VQ1, Q96FD0
      Related
      ENSP00000223145.5, ENST00000223145.10
      Conserved Domains (1) summary
      pfam15388
      Location:167477
      FAM117; Protein Family FAM117

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      7968796..8089080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      8087312..8207580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)