Format

Send to:

Choose Destination
    • Showing Current items.

    ADAT3 adenosine deaminase tRNA specific 3 [ Homo sapiens (human) ]

    Gene ID: 113179, updated on 11-Jun-2021

    Summary

    Official Symbol
    ADAT3provided by HGNC
    Official Full Name
    adenosine deaminase tRNA specific 3provided by HGNC
    Primary source
    HGNC:HGNC:25151
    See related
    Ensembl:ENSG00000213638 MIM:615302
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TAD3; MRT36; FWP005; MST121; S863-5; MSTP121
    Summary
    This gene encodes a subunit of a tRNA-specific adenosine deaminase. This heterodimeric enzyme converts adenosine to inosine in the tRNA anticodon. A mutation in this gene causes a syndrome characterized by intellectual disability and strabismus. This gene shares its 5' exon with the overlapping gene, secretory carrier membrane protein 4 (Gene ID: 113178). [provided by RefSeq, Jul 2016]
    Expression
    Broad expression in colon (RPKM 2.1), stomach (RPKM 1.3) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ADAT3 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (1905399..1913447)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (1905398..1913446)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 17A, depalmitoylase Neighboring gene Sharpr-MPRA regulatory region 13932 Neighboring gene secretory carrier membrane protein 4 Neighboring gene uncharacterized LOC105372238 Neighboring gene casein kinase 1 gamma 2 Neighboring gene CSNK1G2 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to tRNA-specific adenosine-34 deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in tRNA modification TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    probable inactive tRNA-specific adenosine deaminase-like protein 3
    Names
    adenosine deaminase, tRNA-specific 3, TAD3 homolog
    tRNA-specific adenosine-34 deaminase subunit ADAT3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051211.1 RefSeqGene

      Range
      5186..13234
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001329533.2NP_001316462.1  probable inactive tRNA-specific adenosine deaminase-like protein 3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream translation start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      BC011824, HY023983
      UniProtKB/Swiss-Prot
      Q96EY9
      Conserved Domains (1) summary
      COG0590
      Location:195345
      TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]
    2. NM_138422.4NP_612431.2  probable inactive tRNA-specific adenosine deaminase-like protein 3 isoform 1

      See identical proteins and their annotated locations for NP_612431.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC011824, DB127534
      Consensus CDS
      CCDS12076.2
      UniProtKB/Swiss-Prot
      Q96EY9
      UniProtKB/TrEMBL
      D6W601
      Related
      ENSP00000332448.2, ENST00000329478.4
      Conserved Domains (1) summary
      COG0590
      Location:211361
      TadA; tRNA(Arg) A34 adenosine deaminase TadA [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      1905399..1913447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Support Center