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    Abi1 abl interactor 1 [ Mus musculus (house mouse) ]

    Gene ID: 11308, updated on 22-Aug-2021

    Summary

    Official Symbol
    Abi1provided by MGI
    Official Full Name
    abl interactor 1provided by MGI
    Primary source
    MGI:MGI:104913
    See related
    Ensembl:ENSMUSG00000058835
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E3B1; NAP1; Ssh3; abi-1; Ssh3bp1
    Expression
    Ubiquitous expression in bladder adult (RPKM 20.0), cortex adult (RPKM 19.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Abi1 in Genome Data Viewer
    Location:
    2 A3; 2 15.18 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (22830085..22930275, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (22940073..23040241, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (22795509..22895760, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein Neighboring gene predicted gene, 52503 Neighboring gene prenyl (solanesyl) diphosphate synthase, subunit 1 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene predicted gene, 52502 Neighboring gene acyl-Coenzyme A binding domain containing 5 Neighboring gene microtubule associated serine/threonine kinase-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC6064

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of SCAR complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SCAR complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in filopodium tip ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intracellular anatomical structure IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in intracellular anatomical structure ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    abl interactor 1
    Names
    abelson interactor 1
    ablphilin-1
    eps8 SH3 domain-binding protein
    eps8 binding protein
    spectrin SH3 domain binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077190.3NP_001070658.1  abl interactor 1 isoform 1

      See identical proteins and their annotated locations for NP_001070658.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
      Source sequence(s)
      AK034476, AK164040, BP767858, BY278454
      Consensus CDS
      CCDS38061.1
      UniProtKB/Swiss-Prot
      Q8CBW3
      UniProtKB/TrEMBL
      Q3TPY5
      Related
      ENSMUSP00000118491.2, ENSMUST00000123948.8
      Conserved Domains (2) summary
      cd11971
      Location:423481
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93169
      Abi_HHR; Abl-interactor HHR
    2. NM_001077192.3NP_001070660.1  abl interactor 1 isoform 4

      See identical proteins and their annotated locations for NP_001070660.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons and uses an alternate in-frame splice site compared to variant 1. The resulting protein (isoform 4) is shorter compared to isoform 1.
      Source sequence(s)
      AK164040, AY033645, BP767858, BY278454
      Consensus CDS
      CCDS38060.1
      UniProtKB/Swiss-Prot
      Q8CBW3
      UniProtKB/TrEMBL
      Q3TPY5
      Related
      ENSMUSP00000120621.2, ENSMUST00000149719.8
      Conserved Domains (2) summary
      pfam07815
      Location:93164
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:388446
      SH3; Src Homology 3 domain superfamily
    3. NM_001077193.3NP_001070661.1  abl interactor 1 isoform 5

      See identical proteins and their annotated locations for NP_001070661.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks three alternate in-frame exons compared to variant 1. The resulting protein (isoform 5) is shorter compared to isoform 1.
      Source sequence(s)
      AK152061, AK164040, BP767858, BY278454
      Consensus CDS
      CCDS38058.1
      UniProtKB/Swiss-Prot
      Q8CBW3
      UniProtKB/TrEMBL
      Q3TPY5
      Related
      ENSMUSP00000110191.4, ENSMUST00000114544.10
      Conserved Domains (2) summary
      pfam07815
      Location:93154
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:330388
      SH3; Src Homology 3 domain superfamily
    4. NM_001331043.1NP_001317972.1  abl interactor 1 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting protein (isoform 6) is one amino acid shorter than isoform 1.
      Source sequence(s)
      AK164040, BP767858, BY278454, CJ135811, EL607233
      Consensus CDS
      CCDS84480.1
      UniProtKB/TrEMBL
      B7ZCU0, Q3TPY5
      Related
      ENSMUSP00000088957.7, ENSMUST00000091394.13
    5. NM_001331044.1NP_001317973.1  abl interactor 1 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting protein (isoform 7) is shorter compared to isoform 1.
      Source sequence(s)
      AK152046, AK164040, BP767858, BY278454, CJ135811
      Consensus CDS
      CCDS84481.1
      UniProtKB/TrEMBL
      B7ZCU3, Q3TPY5
      Related
      ENSMUSP00000077997.8, ENSMUST00000078977.14
    6. NM_001331045.1NP_001317974.1  abl interactor 1 isoform 8

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting protein (isoform 8) is shorter compared to isoform 1.
      Source sequence(s)
      AK152046, AK164040, BP767858, BY278454, CJ135811, CX212013
      Consensus CDS
      CCDS84479.1
      UniProtKB/TrEMBL
      B7ZCU4, Q3TPY5
      Related
      ENSMUSP00000090860.7, ENSMUST00000093171.13
    7. NM_001377510.1NP_001364439.1  abl interactor 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      Conserved Domains (2) summary
      pfam07815
      Location:93154
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:389447
      SH3; Src Homology 3 domain superfamily
    8. NM_001377511.1NP_001364440.1  abl interactor 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      Conserved Domains (1) summary
      cl17036
      Location:209267
      SH3; Src Homology 3 domain superfamily
    9. NM_001377512.1NP_001364441.1  abl interactor 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      Conserved Domains (2) summary
      pfam07815
      Location:127
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:206264
      SH3; Src Homology 3 domain superfamily
    10. NM_001377513.1NP_001364442.1  abl interactor 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      Conserved Domains (1) summary
      cl17036
      Location:162220
      SH3; Src Homology 3 domain superfamily
    11. NM_007380.4NP_031406.2  abl interactor 1 isoform 3

      See identical proteins and their annotated locations for NP_031406.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site compared to variant 1. The resulting protein (isoform 3) is shorter compared to isoform 1.
      Source sequence(s)
      AK164040, AK167328, BP767858, BY278454
      Consensus CDS
      CCDS50513.1
      UniProtKB/Swiss-Prot
      Q8CBW3
      UniProtKB/TrEMBL
      Q3TJR5, Q3TPY5
      Related
      ENSMUSP00000120462.2, ENSMUST00000140164.8
      Conserved Domains (2) summary
      cd11971
      Location:417475
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93164
      Abi_HHR; Abl-interactor HHR
    12. NM_145994.3NP_666106.1  abl interactor 1 isoform 2

      See identical proteins and their annotated locations for NP_666106.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
      Source sequence(s)
      AK164040, AK167568, BP767858, BY278454
      Consensus CDS
      CCDS38059.1
      UniProtKB/TrEMBL
      Q3TJ64, Q3TPY5
      Related
      ENSMUSP00000117335.2, ENSMUST00000126112.8
      Conserved Domains (2) summary
      cd11971
      Location:418476
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93164
      Abi_HHR; Abl-interactor HHR

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      22830085..22930275 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497619.3XP_006497682.1  abl interactor 1 isoform X1

      See identical proteins and their annotated locations for XP_006497682.1

      UniProtKB/TrEMBL
      B7ZCU2
      Related
      ENSMUSP00000120769.2, ENSMUST00000153931.8
      Conserved Domains (2) summary
      pfam07815
      Location:93156
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:335393
      SH3; Src Homology 3 domain superfamily
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