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    Abi1 abl interactor 1 [ Mus musculus (house mouse) ]

    Gene ID: 11308, updated on 18-Sep-2024

    Summary

    Official Symbol
    Abi1provided by MGI
    Official Full Name
    abl interactor 1provided by MGI
    Primary source
    MGI:MGI:104913
    See related
    Ensembl:ENSMUSG00000058835 AllianceGenome:MGI:104913
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E3B1; NAP1; abi-1; Ssh3bp1
    Summary
    Enables protein tyrosine kinase activator activity and signaling adaptor activity. Acts upstream of or within megakaryocyte development; plasma membrane bounded cell projection morphogenesis; and somitogenesis. Located in lamellipodium and neuron projection. Part of SCAR complex. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Orthologous to human ABI1 (abl interactor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 20.0), cortex adult (RPKM 19.0) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Abi1 in Genome Data Viewer
    Location:
    2 A3; 2 15.18 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (22830085..22930207, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (22940073..23040241, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene amyloid beta precursor protein binding family B member 1 interacting protein Neighboring gene STARR-seq mESC enhancer starr_03920 Neighboring gene STARR-seq mESC enhancer starr_03922 Neighboring gene predicted gene, 52503 Neighboring gene prenyl (solanesyl) diphosphate synthase, subunit 1 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_03923 Neighboring gene STARR-positive B cell enhancer mm9_chr2:22895642-22895943 Neighboring gene STARR-positive B cell enhancer mm9_chr2:22896813-22897114 Neighboring gene predicted gene, 52502 Neighboring gene STARR-seq mESC enhancer starr_03925 Neighboring gene STARR-positive B cell enhancer ABC_E2030 Neighboring gene STARR-positive B cell enhancer ABC_E3360 Neighboring gene acyl-Coenzyme A binding domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E2602 Neighboring gene microtubule associated serine/threonine kinase-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC6064

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH3 domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine kinase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of SCAR complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SCAR complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of SCAR complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in actin-based cell projection IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell leading edge IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in filopodium tip IEA
    Inferred from Electronic Annotation
    more info
     
    located_in filopodium tip ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular anatomical structure ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in lamellipodium IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynaptic density IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    abl interactor 1
    Names
    abelson interactor 1
    ablphilin-1
    eps8 SH3 domain-binding protein
    eps8 binding protein
    spectrin SH3 domain binding protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077190.4NP_001070658.1  abl interactor 1 isoform 1

      See identical proteins and their annotated locations for NP_001070658.1

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      Consensus CDS
      CCDS38061.1
      UniProtKB/Swiss-Prot
      Q3U8V0, Q60747, Q8CBW3, Q91ZM5, Q923I9, Q99KH4
      UniProtKB/TrEMBL
      J3QNK8
      Related
      ENSMUSP00000118491.2, ENSMUST00000123948.8
      Conserved Domains (2) summary
      cd11971
      Location:423481
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93169
      Abi_HHR; Abl-interactor HHR
    2. NM_001077192.4NP_001070660.1  abl interactor 1 isoform 4

      See identical proteins and their annotated locations for NP_001070660.1

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      Consensus CDS
      CCDS38060.1
      UniProtKB/TrEMBL
      Q3TMI0, Q3TPY5, Q3UAH6
      Related
      ENSMUSP00000120621.2, ENSMUST00000149719.8
      Conserved Domains (2) summary
      pfam07815
      Location:93164
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:388446
      SH3; Src Homology 3 domain superfamily
    3. NM_001077193.4NP_001070661.1  abl interactor 1 isoform 5

      See identical proteins and their annotated locations for NP_001070661.1

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      Consensus CDS
      CCDS38058.1
      UniProtKB/TrEMBL
      Q3TMI0, Q3UAH6
      Related
      ENSMUSP00000110191.4, ENSMUST00000114544.10
      Conserved Domains (2) summary
      pfam07815
      Location:93154
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:330388
      SH3; Src Homology 3 domain superfamily
    4. NM_001331043.2NP_001317972.1  abl interactor 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      Consensus CDS
      CCDS84480.1
      UniProtKB/TrEMBL
      B7ZCU0, J3QNK8
      Related
      ENSMUSP00000088957.7, ENSMUST00000091394.13
    5. NM_001331044.2NP_001317973.1  abl interactor 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      Consensus CDS
      CCDS84481.1
      UniProtKB/TrEMBL
      B7ZCU3, Q3TMI0, Q3UAH6
      Related
      ENSMUSP00000077997.8, ENSMUST00000078977.14
    6. NM_001331045.2NP_001317974.1  abl interactor 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      Consensus CDS
      CCDS84479.1
      UniProtKB/TrEMBL
      B7ZCU4, Q3TMI0, Q3UAH6
      Related
      ENSMUSP00000090860.7, ENSMUST00000093171.13
    7. NM_001377510.2NP_001364439.1  abl interactor 1 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      UniProtKB/TrEMBL
      Q3TMI0, Q3UAH6
      Conserved Domains (2) summary
      pfam07815
      Location:93154
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:389447
      SH3; Src Homology 3 domain superfamily
    8. NM_001377511.2NP_001364440.1  abl interactor 1 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      UniProtKB/TrEMBL
      Q3UBL3
      Conserved Domains (1) summary
      cl17036
      Location:209267
      SH3; Src Homology 3 domain superfamily
    9. NM_001377512.2NP_001364441.1  abl interactor 1 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      UniProtKB/TrEMBL
      Q3UBL3
      Conserved Domains (2) summary
      pfam07815
      Location:127
      Abi_HHR; Abl-interactor HHR
      cl17036
      Location:206264
      SH3; Src Homology 3 domain superfamily
    10. NM_001377513.2NP_001364442.1  abl interactor 1 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      Conserved Domains (1) summary
      cl17036
      Location:162220
      SH3; Src Homology 3 domain superfamily
    11. NM_001416851.1NP_001403780.1  abl interactor 1 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      UniProtKB/TrEMBL
      J3QNK8
    12. NM_001416852.1NP_001403781.1  abl interactor 1 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      UniProtKB/TrEMBL
      B7ZCU5, Q3TMI0, Q3UAH6
      Related
      ENSMUSP00000116093.2, ENSMUST00000139038.8
    13. NM_001416853.1NP_001403782.1  abl interactor 1 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      UniProtKB/TrEMBL
      J3QNK8
    14. NM_001416854.1NP_001403783.1  abl interactor 1 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      UniProtKB/TrEMBL
      J3QNK8
    15. NM_001416855.1NP_001403784.1  abl interactor 1 isoform 17

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      UniProtKB/TrEMBL
      J3QNK8
    16. NM_001416856.1NP_001403785.1  abl interactor 1 isoform 18

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      UniProtKB/TrEMBL
      Q3TMI0, Q3UAH6
    17. NM_001416857.1NP_001403786.1  abl interactor 1 isoform 19

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      UniProtKB/TrEMBL
      J3QNK8
    18. NM_001416858.1NP_001403787.1  abl interactor 1 isoform 20

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      UniProtKB/TrEMBL
      J3QNK8
    19. NM_001416859.1NP_001403788.1  abl interactor 1 isoform 21

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      UniProtKB/TrEMBL
      B7ZCU2, Q3TMI0, Q3UAH6
      Related
      ENSMUSP00000120769.2, ENSMUST00000153931.8
    20. NM_001416860.1NP_001403789.1  abl interactor 1 isoform 22

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      UniProtKB/TrEMBL
      Q3TMI0, Q3UAH6
    21. NM_001416861.1NP_001403790.1  abl interactor 1 isoform 23

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      UniProtKB/TrEMBL
      Q3UAH6
    22. NM_001416862.1NP_001403791.1  abl interactor 1 isoform 24

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      UniProtKB/TrEMBL
      Q3UAH6
    23. NM_001416863.1NP_001403792.1  abl interactor 1 isoform 25

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      UniProtKB/TrEMBL
      Q3TMI0, Q3UAH6
    24. NM_001416864.1NP_001403793.1  abl interactor 1 isoform 26

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      UniProtKB/TrEMBL
      Q3UAH6
    25. NM_001416865.1NP_001403794.1  abl interactor 1 isoform 27

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
    26. NM_001416866.1NP_001403795.1  abl interactor 1 isoform 28

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
    27. NM_007380.5NP_031406.2  abl interactor 1 isoform 3

      See identical proteins and their annotated locations for NP_031406.2

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      Consensus CDS
      CCDS50513.1
      UniProtKB/TrEMBL
      J3QNK8, Q3TJR5
      Related
      ENSMUSP00000120462.2, ENSMUST00000140164.8
      Conserved Domains (2) summary
      cd11971
      Location:417475
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93164
      Abi_HHR; Abl-interactor HHR
    28. NM_145994.4NP_666106.1  abl interactor 1 isoform 2

      See identical proteins and their annotated locations for NP_666106.1

      Status: VALIDATED

      Source sequence(s)
      AL845257, CT030013
      Consensus CDS
      CCDS38059.1
      UniProtKB/TrEMBL
      J3QNK8, Q3TJ64
      Related
      ENSMUSP00000117335.2, ENSMUST00000126112.8
      Conserved Domains (2) summary
      cd11971
      Location:418476
      SH3_Abi1; Src homology 3 domain of Abl Interactor 1
      pfam07815
      Location:93164
      Abi_HHR; Abl-interactor HHR

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      22830085..22930207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)