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    WDR89 WD repeat domain 89 [ Homo sapiens (human) ]

    Gene ID: 112840, updated on 17-Jun-2024

    Summary

    Official Symbol
    WDR89provided by HGNC
    Official Full Name
    WD repeat domain 89provided by HGNC
    Primary source
    HGNC:HGNC:20489
    See related
    Ensembl:ENSG00000140006 AllianceGenome:HGNC:20489
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MSTP050; C14orf150
    Expression
    Ubiquitous expression in lymph node (RPKM 4.5), thyroid (RPKM 4.4) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See WDR89 in Genome Data Viewer
    Location:
    14q23.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (63597039..63641871, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (57804429..57849265, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (64063757..64108589, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein L31 pseudogene 5 Neighboring gene glycine C-acetyltransferase pseudogene 1 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 2 Neighboring gene RNA, U6 small nuclear 597, pseudogene Neighboring gene RNA, U6 small nuclear 1162, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:64108177-64108836 Neighboring gene uncharacterized LOC105370532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8512 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8513 Neighboring gene uncharacterized LOC124903437 Neighboring gene uncharacterized LOC124903439

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    WD repeat-containing protein 89

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008726.3NP_001008726.1  WD repeat-containing protein 89

      See identical proteins and their annotated locations for NP_001008726.1

      Status: VALIDATED

      Source sequence(s)
      BC010698, BP278550, DA882425
      Consensus CDS
      CCDS9759.1
      UniProtKB/Swiss-Prot
      Q96FK6
      Conserved Domains (2) summary
      sd00039
      Location:74112
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:41349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    2. NM_001258272.2NP_001245201.1  WD repeat-containing protein 89

      See identical proteins and their annotated locations for NP_001245201.1

      Status: VALIDATED

      Source sequence(s)
      BC010698, BP278550, DA882425, DB178690
      Consensus CDS
      CCDS9759.1
      UniProtKB/Swiss-Prot
      Q96FK6
      Related
      ENSP00000267522.3, ENST00000267522.7
      Conserved Domains (2) summary
      sd00039
      Location:74112
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:41349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    3. NM_001382423.1NP_001369352.1  WD repeat-containing protein 89

      Status: VALIDATED

      Source sequence(s)
      AL136038
      Consensus CDS
      CCDS9759.1
      UniProtKB/Swiss-Prot
      Q96FK6
      Conserved Domains (2) summary
      sd00039
      Location:74112
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:41349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    4. NM_001382424.1NP_001369353.1  WD repeat-containing protein 89

      Status: VALIDATED

      Source sequence(s)
      AL136038
      Consensus CDS
      CCDS9759.1
      UniProtKB/Swiss-Prot
      Q96FK6
      Conserved Domains (2) summary
      sd00039
      Location:74112
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:41349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    5. NM_001382425.1NP_001369354.1  WD repeat-containing protein 89

      Status: VALIDATED

      Source sequence(s)
      AL136038
      Consensus CDS
      CCDS9759.1
      UniProtKB/Swiss-Prot
      Q96FK6
      Conserved Domains (2) summary
      sd00039
      Location:74112
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:41349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    6. NM_001382426.1NP_001369355.1  WD repeat-containing protein 89

      Status: VALIDATED

      Source sequence(s)
      AL136038
      Consensus CDS
      CCDS9759.1
      UniProtKB/Swiss-Prot
      Q96FK6
      Conserved Domains (2) summary
      sd00039
      Location:74112
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:41349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    7. NM_001382427.1NP_001369356.1  WD repeat-containing protein 89

      Status: VALIDATED

      Source sequence(s)
      AL136038
      Consensus CDS
      CCDS9759.1
      UniProtKB/Swiss-Prot
      Q96FK6
      Conserved Domains (2) summary
      sd00039
      Location:74112
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:41349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    8. NM_001382428.1NP_001369357.1  WD repeat-containing protein 89

      Status: VALIDATED

      Source sequence(s)
      AL136038
      Consensus CDS
      CCDS9759.1
      UniProtKB/Swiss-Prot
      Q96FK6
      Conserved Domains (2) summary
      sd00039
      Location:74112
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:41349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    9. NM_001382429.1NP_001369358.1  WD repeat-containing protein 89

      Status: VALIDATED

      Source sequence(s)
      AL136038
      Consensus CDS
      CCDS9759.1
      UniProtKB/Swiss-Prot
      Q96FK6
      Conserved Domains (2) summary
      sd00039
      Location:74112
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:41349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    10. NM_080666.4NP_542397.1  WD repeat-containing protein 89

      See identical proteins and their annotated locations for NP_542397.1

      Status: VALIDATED

      Source sequence(s)
      BC010698, DA882425
      Consensus CDS
      CCDS9759.1
      UniProtKB/Swiss-Prot
      Q96FK6
      Related
      ENSP00000480112.1, ENST00000620954.2
      Conserved Domains (2) summary
      sd00039
      Location:74112
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:41349
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      63597039..63641871 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011536383.3XP_011534685.1  WD repeat-containing protein 89 isoform X1

      Conserved Domains (3) summary
      COG2319
      Location:69387
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:112150
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:79387
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      57804429..57849265 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375310.1XP_054231285.1  WD repeat-containing protein 89 isoform X1