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    CYP4F8 cytochrome P450 family 4 subfamily F member 8 [ Homo sapiens (human) ]

    Gene ID: 11283, updated on 17-Jun-2024

    Summary

    Official Symbol
    CYP4F8provided by HGNC
    Official Full Name
    cytochrome P450 family 4 subfamily F member 8provided by HGNC
    Primary source
    HGNC:HGNC:2648
    See related
    Ensembl:ENSG00000186526 MIM:611545; AllianceGenome:HGNC:2648
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPF8; CYPIVF8
    Summary
    This gene, CYP4F8, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and functions as a 19-hydroxylase of prostaglandins in seminal vesicles. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F3, is approximately 18 kb away. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in prostate (RPKM 2.3), skin (RPKM 0.2) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CYP4F8 in Genome Data Viewer
    Location:
    19p13.12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (15615218..15630639)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (15740324..15755884)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15726029..15741449)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904644 Neighboring gene ribosomal protein L23a pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10286 Neighboring gene cytochrome P450 family 4 subfamily F member 3 Neighboring gene cytochrome P450 family 4 subfamily F member 10, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alkane 1-monooxygenase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables aromatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables monooxygenase activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in icosanoid metabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in prostaglandin metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    cytochrome P450 4F8
    Names
    cytochrome P450, family 4, subfamily F, polypeptide 8
    cytochrome P450, subfamily IVF, polypeptide 8
    flavoprotein-linked monooxygenase
    microsomal monooxygenase
    NP_009184.1
    XP_024307109.1
    XP_054175663.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008068.1 RefSeqGene

      Range
      5001..20422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_007253.4NP_009184.1  cytochrome P450 4F8

      See identical proteins and their annotated locations for NP_009184.1

      Status: REVIEWED

      Source sequence(s)
      AD000685, AF133298, AI401776, DA871128, DA877298, DB329701
      Consensus CDS
      CCDS74303.1
      UniProtKB/Swiss-Prot
      P98187
      UniProtKB/TrEMBL
      B2RBJ0
      Related
      ENSP00000477567.1, ENST00000612078.5
      Conserved Domains (1) summary
      pfam00067
      Location:52504
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      15615218..15630639
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024451341.2XP_024307109.1  cytochrome P450 4F8 isoform X1

      UniProtKB/TrEMBL
      B2RBJ0
      Related
      ENST00000441682.6
      Conserved Domains (1) summary
      pfam00067
      Location:52417
      p450; Cytochrome P450

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      15740324..15755884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319688.1XP_054175663.1  cytochrome P450 4F8 isoform X1

      UniProtKB/TrEMBL
      B2RBJ0