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    FDX2 ferredoxin 2 [ Homo sapiens (human) ]

    Gene ID: 112812, updated on 19-Jul-2022

    Summary

    Official Symbol
    FDX2provided by HGNC
    Official Full Name
    ferredoxin 2provided by HGNC
    Primary source
    HGNC:HGNC:30546
    See related
    Ensembl:ENSG00000267673 MIM:614585; AllianceGenome:HGNC:30546
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FDX1L; MEOAL
    Summary
    This gene encodes a member of the ferredoxin family. The encoded protein contains a 2Fe-2S ferredoxin-type domain and is essential for heme A and Fe/S protein biosynthesis. Mutation in FDX1L gene is associated with mitochondrial muscle myopathy. [provided by RefSeq, Sep 2014]
    Expression
    Ubiquitous expression in brain (RPKM 12.1), thyroid (RPKM 8.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See FDX2 in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (10310045..10316015, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (10436158..10442125, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (10420721..10426691, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr19.1775 Neighboring gene zinc finger GATA like protein 1 Neighboring gene ribonucleoprotein, PTB binding 1 Neighboring gene intercellular adhesion molecule 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC19604, MGC74760

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables electron transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in P450-containing electron transport chain IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in iron-sulfur cluster assembly IC
    Inferred by Curator
    more info
    PubMed 
    involved_in positive regulation of oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of iron-sulfur cluster assembly complex IC
    Inferred by Curator
    more info
    PubMed 
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion IC
    Inferred by Curator
    more info
    PubMed 

    General protein information

    Preferred Names
    ferredoxin-2, mitochondrial
    Names
    adrenodoxin-like protein, mitochondrial
    ferredoxin 1 like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034259.1 RefSeqGene

      Range
      5001..10971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001397406.1NP_001384335.1  ferredoxin-2, mitochondrial

      Status: REVIEWED

      Source sequence(s)
      AC011511
      Consensus CDS
      CCDS32905.2
      Related
      ENSP00000377311.5, ENST00000393708.3
      Conserved Domains (1) summary
      PLN02593
      Location:68183
      PLN02593; adrenodoxin-like ferredoxin protein

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      10310045..10316015 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      10436158..10442125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_080665.3: Suppressed sequence

      Description
      NM_080665.3: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.