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    CHRM1 cholinergic receptor muscarinic 1 [ Homo sapiens (human) ]

    Gene ID: 1128, updated on 11-Apr-2024

    Summary

    Official Symbol
    CHRM1provided by HGNC
    Official Full Name
    cholinergic receptor muscarinic 1provided by HGNC
    Primary source
    HGNC:HGNC:1950
    See related
    Ensembl:ENSG00000168539 MIM:118510; AllianceGenome:HGNC:1950
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    M1; HM1; M1R
    Summary
    The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in prostate (RPKM 24.3), brain (RPKM 18.2) and 4 other tissues See more
    Orthologs
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    Genomic context

    See CHRM1 in Genome Data Viewer
    Location:
    11q12.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62908679..62921878, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62898039..62911241, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62676151..62688835, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4863 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4864 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62623439-62624412 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62624413-62625388 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:62625389-62626362 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:62626363-62627337 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:62628506-62629410 Neighboring gene small nucleolar RNA, C/D box 25 Neighboring gene small nucleolar RNA host gene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:62634014-62634172 Neighboring gene solute carrier family 3 member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4865 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:62648644-62649843 Neighboring gene uncharacterized LOC124902683 Neighboring gene uncharacterized LOC105369333 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62689159-62689693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4868 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62692895-62693660 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62701569-62702077 Neighboring gene RNA, 7SL, cytoplasmic 259, pseudogene Neighboring gene Sharpr-MPRA regulatory region 15118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62751576-62752126 Neighboring gene solute carrier family 22 member 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC30125

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled acetylcholine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled serotonin receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol phospholipase C activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled acetylcholine receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in G protein-coupled serotonin receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cognition IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in neuromuscular synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of monoatomic ion transport IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein kinase C-activating G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of glial cell proliferation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of locomotion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in saliva secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon terminus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cholinergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic density membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    muscarinic acetylcholine receptor M1
    Names
    acetylcholine receptor, muscarinic 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000738.3NP_000729.2  muscarinic acetylcholine receptor M1

      See identical proteins and their annotated locations for NP_000729.2

      Status: REVIEWED

      Source sequence(s)
      BC022984
      Consensus CDS
      CCDS8040.1
      UniProtKB/Swiss-Prot
      P11229, Q96RH1
      UniProtKB/TrEMBL
      Q53XZ3
      Related
      ENSP00000306490.3, ENST00000306960.4
      Conserved Domains (1) summary
      cd17790
      Location:26429
      7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      62908679..62921878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544742.3XP_011543044.1  muscarinic acetylcholine receptor M1 isoform X1

      See identical proteins and their annotated locations for XP_011543044.1

      UniProtKB/Swiss-Prot
      P11229, Q96RH1
      UniProtKB/TrEMBL
      Q53XZ3
      Conserved Domains (1) summary
      cd17790
      Location:26429
      7tmA_mAChR_M1; muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      62898039..62911241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054367566.1XP_054223541.1  muscarinic acetylcholine receptor M1 isoform X1

      UniProtKB/Swiss-Prot
      P11229, Q96RH1
      UniProtKB/TrEMBL
      Q53XZ3