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    SYNRG synergin gamma [ Homo sapiens (human) ]

    Gene ID: 11276, updated on 7-Apr-2024

    Summary

    Official Symbol
    SYNRGprovided by HGNC
    Official Full Name
    synergin gammaprovided by HGNC
    Primary source
    HGNC:HGNC:557
    See related
    Ensembl:ENSG00000275066 MIM:607291; AllianceGenome:HGNC:557
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SYNG; AP1GBP1
    Summary
    This gene encodes a protein that interacts with the gamma subunit of AP1 clathrin-adaptor complex. The AP1 complex is located at the trans-Golgi network and associates specific proteins with clathrin-coated vesicles. This encoded protein may act to connect the AP1 complex to other proteins. Alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 8.0), spleen (RPKM 6.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    17q12
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (37514807..37609418, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (38501491..38596398, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (35874910..35969466, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene transcriptional adaptor 2A Neighboring gene ribosomal protein L24 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr17:35814497-35815074 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:35815591-35816092 Neighboring gene MPRA-validated peak2830 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35843239-35843740 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35851097-35851882 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35867619-35868119 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:35867118-35867618 Neighboring gene dual specificity phosphatase 14 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:35872759-35873272 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:35901785-35902984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35949209-35949710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:35949711-35950210 Neighboring gene microRNA 378j Neighboring gene DExD-box helicase 52 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:36001021-36001522 Neighboring gene uncharacterized LOC105371756

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.
    EBI GWAS Catalog
    GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ34482, MGC104959

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular protein transport TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of AP-1 adaptor complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in Golgi apparatus TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of clathrin coat of trans-Golgi network vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    synergin gamma
    Names
    AP1 gamma subunit binding protein 1
    AP1 subunit gamma-binding protein 1
    adaptor-related protein complex 1 gamma subunit-binding protein 1
    gamma-synergin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163544.3NP_001157016.1  synergin gamma isoform 4

      See identical proteins and their annotated locations for NP_001157016.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (4) that is shorter than isoform 1.
      Source sequence(s)
      AC243585, AF169548, BC143478, DB085203, N93929
      Conserved Domains (2) summary
      cd00052
      Location:238289
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cl00928
      Location:116150
      dsDNA_bind; Double-stranded DNA-binding domain
    2. NM_001163545.3NP_001157017.1  synergin gamma isoform 5

      See identical proteins and their annotated locations for NP_001157017.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region and lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (5) that is shorter than isoform 1.
      Source sequence(s)
      AC243585, AF169548, BC117313, DB085203, N93929
      Consensus CDS
      CCDS59284.1
      Related
      ENSP00000477885.1, ENST00000619541.4
      Conserved Domains (2) summary
      cd00052
      Location:237288
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cl00928
      Location:115149
      dsDNA_bind; Double-stranded DNA-binding domain
    3. NM_001163546.3NP_001157018.1  synergin gamma isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the central coding region, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (6) that is shorter than isoform 1.
      Source sequence(s)
      AC243585, AF169548, BC084536, BC090930, DB085203, N93929
      Consensus CDS
      CCDS59285.1
      Related
      ENSP00000482962.1, ENST00000616179.4
      Conserved Domains (2) summary
      cd00052
      Location:238289
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cl00928
      Location:116150
      dsDNA_bind; Double-stranded DNA-binding domain
    4. NM_001163547.3NP_001157019.1  synergin gamma isoform 7

      See identical proteins and their annotated locations for NP_001157019.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two alternate in-frame exons and uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (7) that is shorter than isoform 1.
      Source sequence(s)
      AC243585, AF169548, BC143476, DB085203, N93929
      Consensus CDS
      CCDS54113.1
      Related
      ENSP00000481151.1, ENST00000614941.4
      Conserved Domains (2) summary
      cd00052
      Location:238288
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cl00928
      Location:116150
      dsDNA_bind; Double-stranded DNA-binding domain
    5. NM_001405103.1NP_001392032.1  synergin gamma isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC243585
    6. NM_007247.6NP_009178.3  synergin gamma isoform 1

      See identical proteins and their annotated locations for NP_009178.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC243585, AF169548, BC090930, DB085203, N93929
      Consensus CDS
      CCDS11321.1
      UniProtKB/Swiss-Prot
      A8MWU4, B7ZKZ2, B7ZKZ3, Q17RI2, Q5BKU5, Q6ZT17, Q9UMZ2
      Related
      ENSP00000483453.1, ENST00000612223.5
      Conserved Domains (2) summary
      cd00052
      Location:316367
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cl00928
      Location:116150
      dsDNA_bind; Double-stranded DNA-binding domain
    7. NM_080550.5NP_542117.3  synergin gamma isoform 2

      See identical proteins and their annotated locations for NP_542117.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in both the central and 3' coding regions, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC243585, AF169548, BC090930, DB085203, N93929
      Consensus CDS
      CCDS11322.2
      Related
      ENSP00000484529.1, ENST00000621136.4
      Conserved Domains (2) summary
      cd00052
      Location:238289
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cl00928
      Location:116150
      dsDNA_bind; Double-stranded DNA-binding domain
    8. NM_198882.3NP_942583.1  synergin gamma isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region but includes an additional in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AC243585, BC090930, BC143452, DB085203, N93929
      Consensus CDS
      CCDS54114.1
      Related
      ENSP00000483063.1, ENST00000622045.4
      Conserved Domains (2) summary
      cd00052
      Location:238289
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cl00928
      Location:116150
      dsDNA_bind; Double-stranded DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      37514807..37609418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024081.3XP_016879570.1  synergin gamma isoform X44

    2. XM_047435226.1XP_047291182.1  synergin gamma isoform X4

    3. XM_047435249.1XP_047291205.1  synergin gamma isoform X43

    4. XM_047435247.1XP_047291203.1  synergin gamma isoform X41

    5. XM_047435246.1XP_047291202.1  synergin gamma isoform X40

    6. XM_017024102.1XP_016879591.1  synergin gamma isoform X37

    7. XM_017024101.2XP_016879590.1  synergin gamma isoform X36

      Conserved Domains (3) summary
      cd00052
      Location:315366
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam09606
      Location:32130
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      cl00928
      Location:115149
      dsDNA_bind; Double-stranded DNA-binding domain
    8. XM_047435243.1XP_047291199.1  synergin gamma isoform X32

    9. XM_047435245.1XP_047291201.1  synergin gamma isoform X35

    10. XM_047435242.1XP_047291198.1  synergin gamma isoform X31

    11. XM_017024094.2XP_016879583.1  synergin gamma isoform X26

    12. XM_047435240.1XP_047291196.1  synergin gamma isoform X24

    13. XM_047435238.1XP_047291194.1  synergin gamma isoform X22

    14. XM_047435235.1XP_047291191.1  synergin gamma isoform X18

    15. XM_047435231.1XP_047291187.1  synergin gamma isoform X12

    16. XM_047435237.1XP_047291193.1  synergin gamma isoform X21

    17. XM_047435234.1XP_047291190.1  synergin gamma isoform X17

    18. XM_047435230.1XP_047291186.1  synergin gamma isoform X11

    19. XM_047435232.1XP_047291188.1  synergin gamma isoform X13

    20. XM_047435229.1XP_047291185.1  synergin gamma isoform X8

    21. XM_047435227.1XP_047291183.1  synergin gamma isoform X6

    22. XM_047435225.1XP_047291181.1  synergin gamma isoform X3

    23. XM_017024077.1XP_016879566.1  synergin gamma isoform X1

    24. XM_047435248.1XP_047291204.1  synergin gamma isoform X42

    25. XM_017024104.3XP_016879593.1  synergin gamma isoform X39

    26. XM_017024106.2XP_016879595.1  synergin gamma isoform X38

    27. XM_017024100.2XP_016879589.1  synergin gamma isoform X34

    28. XM_017024098.3XP_016879587.1  synergin gamma isoform X30

    29. XM_047435244.1XP_047291200.1  synergin gamma isoform X33

    30. XM_017024097.2XP_016879586.1  synergin gamma isoform X29

    31. XM_017024095.2XP_016879584.1  synergin gamma isoform X27

    32. XM_017024093.3XP_016879582.1  synergin gamma isoform X25

    33. XM_047435241.1XP_047291197.1  synergin gamma isoform X28

    34. XM_047435239.1XP_047291195.1  synergin gamma isoform X23

    35. XM_047435233.1XP_047291189.1  synergin gamma isoform X14

    36. XM_047435236.1XP_047291192.1  synergin gamma isoform X20

    37. XM_017024087.2XP_016879576.1  synergin gamma isoform X16

    38. XM_017024084.2XP_016879573.1  synergin gamma isoform X10

    39. XM_017024089.2XP_016879578.1  synergin gamma isoform X19

    40. XM_017024086.2XP_016879575.1  synergin gamma isoform X15

    41. XM_017024083.2XP_016879572.1  synergin gamma isoform X9

    42. XM_047435228.1XP_047291184.1  synergin gamma isoform X7

    43. XM_017024082.2XP_016879571.1  synergin gamma isoform X5

    44. XM_005256980.6XP_005257037.1  synergin gamma isoform X2

      See identical proteins and their annotated locations for XP_005257037.1

      Conserved Domains (2) summary
      cd00052
      Location:417468
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cl00928
      Location:116150
      dsDNA_bind; Double-stranded DNA-binding domain

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      1753975..1848537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329235.1XP_054185210.1  synergin gamma isoform X4

    2. XM_054329275.1XP_054185250.1  synergin gamma isoform X43

    3. XM_054329273.1XP_054185248.1  synergin gamma isoform X41

    4. XM_054329272.1XP_054185247.1  synergin gamma isoform X40

    5. XM_054329269.1XP_054185244.1  synergin gamma isoform X37

    6. XM_054329267.1XP_054185242.1  synergin gamma isoform X36

    7. XM_054329263.1XP_054185238.1  synergin gamma isoform X32

    8. XM_054329266.1XP_054185241.1  synergin gamma isoform X35

    9. XM_054329262.1XP_054185237.1  synergin gamma isoform X31

    10. XM_054329257.1XP_054185232.1  synergin gamma isoform X26

    11. XM_054329255.1XP_054185230.1  synergin gamma isoform X24

    12. XM_054329253.1XP_054185228.1  synergin gamma isoform X22

    13. XM_054329249.1XP_054185224.1  synergin gamma isoform X18

    14. XM_054329243.1XP_054185218.1  synergin gamma isoform X12

    15. XM_054329252.1XP_054185227.1  synergin gamma isoform X21

    16. XM_054329248.1XP_054185223.1  synergin gamma isoform X17

    17. XM_054329242.1XP_054185217.1  synergin gamma isoform X11

    18. XM_054329244.1XP_054185219.1  synergin gamma isoform X13

    19. XM_054329239.1XP_054185214.1  synergin gamma isoform X8

    20. XM_054329237.1XP_054185212.1  synergin gamma isoform X6

    21. XM_054329234.1XP_054185209.1  synergin gamma isoform X3

    22. XM_054329232.1XP_054185207.1  synergin gamma isoform X1

    23. XM_054329274.1XP_054185249.1  synergin gamma isoform X42

    24. XM_054329271.1XP_054185246.1  synergin gamma isoform X39

    25. XM_054329270.1XP_054185245.1  synergin gamma isoform X38

    26. XM_054329268.1XP_054185243.1  synergin gamma isoform X45

    27. XM_054329265.1XP_054185240.1  synergin gamma isoform X34

    28. XM_054329261.1XP_054185236.1  synergin gamma isoform X30

    29. XM_054329264.1XP_054185239.1  synergin gamma isoform X33

    30. XM_054329260.1XP_054185235.1  synergin gamma isoform X29

    31. XM_054329258.1XP_054185233.1  synergin gamma isoform X27

    32. XM_054329256.1XP_054185231.1  synergin gamma isoform X25

    33. XM_054329259.1XP_054185234.1  synergin gamma isoform X28

    34. XM_054329254.1XP_054185229.1  synergin gamma isoform X23

    35. XM_054329245.1XP_054185220.1  synergin gamma isoform X14

    36. XM_054329251.1XP_054185226.1  synergin gamma isoform X20

    37. XM_054329247.1XP_054185222.1  synergin gamma isoform X16

    38. XM_054329241.1XP_054185216.1  synergin gamma isoform X10

    39. XM_054329250.1XP_054185225.1  synergin gamma isoform X19

    40. XM_054329246.1XP_054185221.1  synergin gamma isoform X15

    41. XM_054329240.1XP_054185215.1  synergin gamma isoform X9

    42. XM_054329238.1XP_054185213.1  synergin gamma isoform X7

    43. XM_054329236.1XP_054185211.1  synergin gamma isoform X5

    44. XM_054329233.1XP_054185208.1  synergin gamma isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      38501491..38596398 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314866.1XP_054170841.1  synergin gamma isoform X4

    2. XM_054314906.1XP_054170881.1  synergin gamma isoform X43

    3. XM_054314904.1XP_054170879.1  synergin gamma isoform X41

    4. XM_054314903.1XP_054170878.1  synergin gamma isoform X40

    5. XM_054314900.1XP_054170875.1  synergin gamma isoform X37

    6. XM_054314898.1XP_054170873.1  synergin gamma isoform X36

    7. XM_054314894.1XP_054170869.1  synergin gamma isoform X32

    8. XM_054314897.1XP_054170872.1  synergin gamma isoform X35

    9. XM_054314893.1XP_054170868.1  synergin gamma isoform X31

    10. XM_054314888.1XP_054170863.1  synergin gamma isoform X26

    11. XM_054314886.1XP_054170861.1  synergin gamma isoform X24

    12. XM_054314884.1XP_054170859.1  synergin gamma isoform X22

    13. XM_054314880.1XP_054170855.1  synergin gamma isoform X18

    14. XM_054314874.1XP_054170849.1  synergin gamma isoform X12

    15. XM_054314883.1XP_054170858.1  synergin gamma isoform X21

    16. XM_054314879.1XP_054170854.1  synergin gamma isoform X17

    17. XM_054314873.1XP_054170848.1  synergin gamma isoform X11

    18. XM_054314875.1XP_054170850.1  synergin gamma isoform X13

    19. XM_054314870.1XP_054170845.1  synergin gamma isoform X8

    20. XM_054314868.1XP_054170843.1  synergin gamma isoform X6

    21. XM_054314865.1XP_054170840.1  synergin gamma isoform X3

    22. XM_054314863.1XP_054170838.1  synergin gamma isoform X1

    23. XM_054314905.1XP_054170880.1  synergin gamma isoform X42

    24. XM_054314902.1XP_054170877.1  synergin gamma isoform X39

    25. XM_054314901.1XP_054170876.1  synergin gamma isoform X38

    26. XM_054314899.1XP_054170874.1  synergin gamma isoform X46

    27. XM_054314896.1XP_054170871.1  synergin gamma isoform X34

    28. XM_054314892.1XP_054170867.1  synergin gamma isoform X30

    29. XM_054314895.1XP_054170870.1  synergin gamma isoform X33

    30. XM_054314891.1XP_054170866.1  synergin gamma isoform X29

    31. XM_054314889.1XP_054170864.1  synergin gamma isoform X27

    32. XM_054314887.1XP_054170862.1  synergin gamma isoform X25

    33. XM_054314890.1XP_054170865.1  synergin gamma isoform X28

    34. XM_054314885.1XP_054170860.1  synergin gamma isoform X23

    35. XM_054314876.1XP_054170851.1  synergin gamma isoform X14

    36. XM_054314882.1XP_054170857.1  synergin gamma isoform X20

    37. XM_054314878.1XP_054170853.1  synergin gamma isoform X16

    38. XM_054314872.1XP_054170847.1  synergin gamma isoform X10

    39. XM_054314881.1XP_054170856.1  synergin gamma isoform X19

    40. XM_054314877.1XP_054170852.1  synergin gamma isoform X15

    41. XM_054314871.1XP_054170846.1  synergin gamma isoform X9

    42. XM_054314869.1XP_054170844.1  synergin gamma isoform X7

    43. XM_054314867.1XP_054170842.1  synergin gamma isoform X5

    44. XM_054314864.1XP_054170839.1  synergin gamma isoform X2