Format

Send to:

Choose Destination
    • Showing Current items.

    IL17F interleukin 17F [ Homo sapiens (human) ]

    Gene ID: 112744, updated on 2-Aug-2021

    Summary

    Official Symbol
    IL17Fprovided by HGNC
    Official Full Name
    interleukin 17Fprovided by HGNC
    Primary source
    HGNC:HGNC:16404
    See related
    Ensembl:ENSG00000112116 MIM:606496
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ML1; ML-1; CANDF6; IL-17F
    Summary
    The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IL17F in Genome Data Viewer
    Location:
    6p12.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (52236681..52245689, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52101479..52109298, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene interleukin 17A Neighboring gene uncharacterized LOC102724327 Neighboring gene solute carrier family 25 member 20 pseudogene 1 Neighboring gene minichromosome maintenance complex component 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
    GeneReviews: Not available
    Candidiasis, familial, 6
    MedGen: C3151405 OMIM: 613956 GeneReviews: Not available
    Compare labs

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cytokine binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cytokine receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cartilage development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in defense response to Gram-negative bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-17-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of antimicrobial peptide production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of chemokine (C-X-C motif) ligand 1 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytokine production involved in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of lymphotoxin A production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of granulocyte macrophage colony-stimulating factor production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of interleukin-2 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of interleukin-8 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of transforming growth factor beta receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    interleukin-17F
    Names
    cytokine ML-1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031869.1 RefSeqGene

      Range
      5001..12815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_356

    mRNA and Protein(s)

    1. NM_052872.4NP_443104.1  interleukin-17F precursor

      See identical proteins and their annotated locations for NP_443104.1

      Status: REVIEWED

      Source sequence(s)
      AF332389, BC070124
      Consensus CDS
      CCDS4938.1
      UniProtKB/Swiss-Prot
      Q96PD4
      Related
      ENSP00000337432.4, ENST00000336123.5
      Conserved Domains (1) summary
      pfam06083
      Location:80154
      IL17; Interleukin-17

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      52236681..52245689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011514276.1XP_011512578.1  interleukin-17F isoform X1

      See identical proteins and their annotated locations for XP_011512578.1

      UniProtKB/Swiss-Prot
      Q96PD4
      Conserved Domains (1) summary
      pfam06083
      Location:80154
      IL17; Interleukin-17

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_172343.1: Suppressed sequence

      Description
      NM_172343.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Support Center