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    USP18 ubiquitin specific peptidase 18 [ Homo sapiens (human) ]

    Gene ID: 11274, updated on 26-Jul-2021

    Summary

    Official Symbol
    USP18provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 18provided by HGNC
    Primary source
    HGNC:HGNC:12616
    See related
    Ensembl:ENSG00000184979 MIM:607057
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ISG43; UBP43; PTORCH2
    Summary
    The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15. [provided by RefSeq, Sep 2011]
    Expression
    Ubiquitous expression in fat (RPKM 6.5), spleen (RPKM 6.3) and 25 other tissues See more
    Orthologs
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    Genomic context

    See USP18 in Genome Data Viewer
    Location:
    22q11.21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 22 NC_000022.11 (18149855..18177397)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (18632937..18660164)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene peroxisomal biogenesis factor 26 Neighboring gene ADP ribosylation factor like GTPase 2 binding protein pseudogene 10 Neighboring gene tubulin alpha 8 Neighboring gene family with sequence similarity 230 member D Neighboring gene uncharacterized LOC105372858

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 and the viral protein Tat modulate the expression of ubiquitin specific peptidase 18 (USP18; ISG43) in immature dendritic cells and monocyte-derived macrophages PubMed
    Vpr vpr HIV-1 Vpr upregulates the gene expression of USP18 in human monocyte-derived dendritic cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ISG15-specific protease activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables thiol-dependent deubiquitinase IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables thiol-dependent deubiquitinase TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    ubl carboxyl-terminal hydrolase 18
    Names
    43 kDa ISG15-specific protease
    ISG15-specific-processing protease
    ubiquitin specific protease 18
    ubl thioesterase 18
    ubl thiolesterase 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017414.4NP_059110.2  ubl carboxyl-terminal hydrolase 18

      See identical proteins and their annotated locations for NP_059110.2

      Status: VALIDATED

      Source sequence(s)
      AC008079
      Consensus CDS
      CCDS13752.1
      UniProtKB/Swiss-Prot
      Q9UMW8
      Related
      ENSP00000215794.7, ENST00000215794.8
      Conserved Domains (1) summary
      pfam00443
      Location:55367
      UCH; Ubiquitin carboxyl-terminal hydrolase

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p13 Primary Assembly

      Range
      18149855..18177397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006724074.3XP_006724137.1  ubl carboxyl-terminal hydrolase 18 isoform X1

      Conserved Domains (2) summary
      cd02257
      Location:60294
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:4293
      UCH; Ubiquitin carboxyl-terminal hydrolase
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