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    SP140 SP140 nuclear body protein [ Homo sapiens (human) ]

    Gene ID: 11262, updated on 17-Jun-2024

    Summary

    Official Symbol
    SP140provided by HGNC
    Official Full Name
    SP140 nuclear body proteinprovided by HGNC
    Primary source
    HGNC:HGNC:17133
    See related
    Ensembl:ENSG00000079263 MIM:608602; AllianceGenome:HGNC:17133
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LYSP100; LYSP100-A; LYSP100-B
    Summary
    This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016]
    Expression
    Biased expression in lymph node (RPKM 12.2), spleen (RPKM 7.6) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SP140 in Genome Data Viewer
    Location:
    2q37.1
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (230186151..230316571)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (230669263..230808985)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (231090451..231177930)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 16 member 14 Neighboring gene uncharacterized LOC107985995 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:230932348-230933118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17208 Neighboring gene RNY4 pseudogene 19 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:231005392-231005920 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12407 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:231044589-231045131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17209 Neighboring gene SP110 nuclear body protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17210 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:231084625-231084811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17212 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17213 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231129497-231130018 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12408 Neighboring gene MPRA-validated peak4075 silencer Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:231176974-231178173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17217 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17218 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:231206345-231206936 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17219 Neighboring gene SP140 nuclear body protein like Neighboring gene uncharacterized LOC105373925 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17220 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17223 Neighboring gene uncharacterized LOC101928816 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17224 Neighboring gene SP100 nuclear antigen Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17225 Neighboring gene RNA, 7SL, cytoplasmic 834, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
    EBI GWAS Catalog
    A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
    EBI GWAS Catalog
    Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia.
    EBI GWAS Catalog
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog
    Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
    EBI GWAS Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif Wild-type HIV-1 Vif binds to the carboxyl-terminal region of Sp140 between amino acids 527-836, while Vif mutants with deletions of amino acids 12-23, 43-59, 73-87 or 97-112 are strongly inhibited in their binding to Sp140 PubMed
    vif HIV-1 Vif may enhance the cytosolic retention of Sp140 PubMed
    vif Specific binding of HIV-1 Vif to Sp140 was identified using a yeast two-hybrid screen of a human lymphocyte cDNA library and verified by co-immunoprecipitation PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126440

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in PML body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear body protein SP140
    Names
    lymphoid-restricted homolog of Sp100
    lymphoid-specific SP100 homolog
    nuclear autoantigen Sp-140
    speckled 140 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051286.2 RefSeqGene

      Range
      44587..132066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001005176.3NP_001005176.1  nuclear body protein SP140 isoform 2

      See identical proteins and their annotated locations for NP_001005176.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' exons, and has an alternate 3' sequence, as compared to variant 1. The encoded isoform 2 is much shorter and has a distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AA741304, AK301267, BC070160
      Consensus CDS
      CCDS33392.1
      UniProtKB/Swiss-Prot
      Q13342
      UniProtKB/TrEMBL
      B4DVW8
      Related
      ENSP00000362749.3, ENST00000373645.3
      Conserved Domains (1) summary
      pfam03172
      Location:42135
      Sp100; Sp100 domain
    2. NM_001278451.2NP_001265380.1  nuclear body protein SP140 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC009949, BC105960, DC391925, U36499
      Consensus CDS
      CCDS63150.1
      UniProtKB/TrEMBL
      Q0VGE4
      Related
      ENSP00000398210.3, ENST00000420434.7
      Conserved Domains (4) summary
      cd05501
      Location:730833
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:665706
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:558633
      SAND; SAND domain
      pfam03172
      Location:42135
      Sp100; Sp100 domain
    3. NM_001278452.2NP_001265381.1  nuclear body protein SP140 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC009949, BC105744, DC391925, U36499
      Consensus CDS
      CCDS63151.1
      UniProtKB/TrEMBL
      Q0VGE4
      Related
      ENSP00000342096.6, ENST00000343805.10
      Conserved Domains (5) summary
      cd05501
      Location:697800
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      PHA03169
      Location:202419
      PHA03169; hypothetical protein; Provisional
      cd15626
      Location:632673
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:525600
      SAND; SAND domain
      pfam03172
      Location:42135
      Sp100; Sp100 domain
    4. NM_001278453.2NP_001265382.1  nuclear body protein SP140 isoform 5

      See identical proteins and their annotated locations for NP_001265382.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks three alternate in-frame exons and uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC009949, AC009950, DC391925, U36499, U63420
      Consensus CDS
      CCDS63149.1
      UniProtKB/TrEMBL
      Q0VGE4
      Related
      ENSP00000393618.3, ENST00000417495.7
      Conserved Domains (4) summary
      cd05501
      Location:643746
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:578619
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:471546
      SAND; SAND domain
      pfam03172
      Location:42135
      Sp100; Sp100 domain
    5. NM_007237.5NP_009168.4  nuclear body protein SP140 isoform 1

      See identical proteins and their annotated locations for NP_009168.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC009949, AK301267, BC038091, BC105960, U36500
      Consensus CDS
      CCDS42831.1
      UniProtKB/Swiss-Prot
      E7ESH9, E7EUR5, E9PFJ6, Q0VGE5, Q13341, Q13342, Q3KR17, Q4ZG66, Q53TG1, Q6NSG4, Q92881, Q96TG3
      UniProtKB/TrEMBL
      Q0VGE4
      Related
      ENSP00000375899.3, ENST00000392045.8
      Conserved Domains (4) summary
      cd05501
      Location:757860
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:692733
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:585660
      SAND; SAND domain
      pfam03172
      Location:42135
      Sp100; Sp100 domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      230186151..230316571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443073.1XP_047299029.1  nuclear body protein SP140 isoform X7

      UniProtKB/TrEMBL
      Q0VGE4
    2. XM_011510517.4XP_011508819.1  nuclear body protein SP140 isoform X7

      See identical proteins and their annotated locations for XP_011508819.1

      UniProtKB/TrEMBL
      Q0VGE4
      Conserved Domains (4) summary
      cd05501
      Location:737840
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:672713
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:565640
      SAND; SAND domain
      pfam03172
      Location:22115
      Sp100; Sp100 domain
    3. XM_006712223.4XP_006712286.1  nuclear body protein SP140 isoform X1

      UniProtKB/TrEMBL
      B4DVW8
      Conserved Domains (4) summary
      cd15626
      Location:692733
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:585660
      SAND; SAND domain
      pfam03172
      Location:42135
      Sp100; Sp100 domain
      cl02556
      Location:757838
      Bromodomain; Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    4. XM_047443077.1XP_047299033.1  nuclear body protein SP140 isoform X21

      UniProtKB/TrEMBL
      B4DVW8
    5. XM_011510518.3XP_011508820.1  nuclear body protein SP140 isoform X7

      See identical proteins and their annotated locations for XP_011508820.1

      UniProtKB/TrEMBL
      Q0VGE4
      Conserved Domains (4) summary
      cd05501
      Location:737840
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:672713
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:565640
      SAND; SAND domain
      pfam03172
      Location:22115
      Sp100; Sp100 domain
    6. XM_011510516.2XP_011508818.1  nuclear body protein SP140 isoform X5

      UniProtKB/TrEMBL
      Q0VGE4
      Conserved Domains (4) summary
      cd05501
      Location:748851
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:692726
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:585660
      SAND; SAND domain
      pfam03172
      Location:42135
      Sp100; Sp100 domain
    7. XM_011510515.2XP_011508817.1  nuclear body protein SP140 isoform X3

      UniProtKB/TrEMBL
      Q0VGE4
      Conserved Domains (4) summary
      cd05501
      Location:751854
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:686727
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:579654
      SAND; SAND domain
      pfam03172
      Location:42135
      Sp100; Sp100 domain
    8. XM_005246254.3XP_005246311.1  nuclear body protein SP140 isoform X13

      UniProtKB/TrEMBL
      Q0VGE4
      Conserved Domains (4) summary
      cd05501
      Location:723826
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:658699
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:551626
      SAND; SAND domain
      pfam03172
      Location:42135
      Sp100; Sp100 domain
    9. XM_011510519.2XP_011508821.1  nuclear body protein SP140 isoform X9

      UniProtKB/TrEMBL
      Q0VGE4
      Conserved Domains (4) summary
      cd05501
      Location:730833
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:665706
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:558633
      SAND; SAND domain
      pfam03172
      Location:42135
      Sp100; Sp100 domain
    10. XM_005246256.3XP_005246313.1  nuclear body protein SP140 isoform X20

      UniProtKB/TrEMBL
      Q0VGE4
      Conserved Domains (4) summary
      cd05501
      Location:696799
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:631672
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:524599
      SAND; SAND domain
      pfam03172
      Location:42135
      Sp100; Sp100 domain
    11. XM_047443078.1XP_047299034.1  nuclear body protein SP140 isoform X24

      UniProtKB/TrEMBL
      Q0VGE4
    12. XM_005246255.3XP_005246312.1  nuclear body protein SP140 isoform X16

      UniProtKB/TrEMBL
      B4DVW8
      Conserved Domains (4) summary
      cd05501
      Location:707810
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:642683
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:535610
      SAND; SAND domain
      pfam03172
      Location:42135
      Sp100; Sp100 domain
    13. XM_047443076.1XP_047299032.1  nuclear body protein SP140 isoform X19

      UniProtKB/TrEMBL
      B4DVW8
    14. XM_017003252.2XP_016858741.1  nuclear body protein SP140 isoform X28

      UniProtKB/TrEMBL
      Q0VGE4
    15. XM_005246253.3XP_005246310.1  nuclear body protein SP140 isoform X8

      UniProtKB/TrEMBL
      Q0VGE4
      Conserved Domains (5) summary
      cd05501
      Location:731834
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      PHA03169
      Location:202453
      PHA03169; hypothetical protein; Provisional
      cd15626
      Location:666707
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:559634
      SAND; SAND domain
      pfam03172
      Location:42135
      Sp100; Sp100 domain
    16. XM_017003240.2XP_016858729.1  nuclear body protein SP140 isoform X12

      UniProtKB/TrEMBL
      Q0VGE4
    17. XM_017003249.2XP_016858738.1  nuclear body protein SP140 isoform X26

      UniProtKB/TrEMBL
      Q0VGE4
    18. XM_005246252.3XP_005246309.1  nuclear body protein SP140 isoform X2

      UniProtKB/TrEMBL
      Q0VGE4
      Conserved Domains (4) summary
      cd05501
      Location:754857
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:689730
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:582657
      SAND; SAND domain
      pfam03172
      Location:42135
      Sp100; Sp100 domain
    19. XM_047443072.1XP_047299028.1  nuclear body protein SP140 isoform X6

      UniProtKB/TrEMBL
      Q0VGE4
    20. XM_017003239.2XP_016858728.1  nuclear body protein SP140 isoform X4

      UniProtKB/TrEMBL
      Q0VGE4
    21. XM_017003243.2XP_016858732.1  nuclear body protein SP140 isoform X15

      UniProtKB/TrEMBL
      Q0VGE4
    22. XM_047443074.1XP_047299030.1  nuclear body protein SP140 isoform X11

      UniProtKB/TrEMBL
      Q0VGE4
    23. XM_017003248.2XP_016858737.1  nuclear body protein SP140 isoform X23

      UniProtKB/TrEMBL
      Q0VGE4
    24. XM_047443079.1XP_047299035.1  nuclear body protein SP140 isoform X25

      UniProtKB/TrEMBL
      Q0VGE4
    25. XM_017003245.2XP_016858734.1  nuclear body protein SP140 isoform X17

      UniProtKB/TrEMBL
      B4DVW8
    26. XM_011510520.2XP_011508822.1  nuclear body protein SP140 isoform X10

      UniProtKB/TrEMBL
      Q0VGE4
      Conserved Domains (4) summary
      cd05501
      Location:728831
      Bromo_SP100C_like; Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin ...
      cd15626
      Location:663704
      PHD_SP110_140; PHD finger found in the Sp100/Sp140 family of nuclear body components
      pfam01342
      Location:556631
      SAND; SAND domain
      pfam03172
      Location:42135
      Sp100; Sp100 domain
    27. XM_017003242.2XP_016858731.1  nuclear body protein SP140 isoform X14

      UniProtKB/TrEMBL
      Q0VGE4
    28. XM_017003247.2XP_016858736.1  nuclear body protein SP140 isoform X22

      UniProtKB/TrEMBL
      Q0VGE4
    29. XM_017003246.2XP_016858735.1  nuclear body protein SP140 isoform X18

      UniProtKB/TrEMBL
      Q0VGE4
    30. XM_017003250.2XP_016858739.1  nuclear body protein SP140 isoform X27

      UniProtKB/TrEMBL
      Q0VGE4
    31. XM_047443080.1XP_047299036.1  nuclear body protein SP140 isoform X29

    32. XM_047443081.1XP_047299037.1  nuclear body protein SP140 isoform X31

    33. XM_017003253.2XP_016858742.1  nuclear body protein SP140 isoform X30

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      230669263..230808985
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340304.1XP_054196279.1  nuclear body protein SP140 isoform X7

      UniProtKB/TrEMBL
      Q0VGE4
    2. XM_054340302.1XP_054196277.1  nuclear body protein SP140 isoform X7

      UniProtKB/TrEMBL
      Q0VGE4
    3. XM_054340296.1XP_054196271.1  nuclear body protein SP140 isoform X1

      UniProtKB/TrEMBL
      B4DVW8
    4. XM_054340318.1XP_054196293.1  nuclear body protein SP140 isoform X21

      UniProtKB/TrEMBL
      Q0VGE4
    5. XM_054340303.1XP_054196278.1  nuclear body protein SP140 isoform X7

      UniProtKB/TrEMBL
      Q0VGE4
    6. XM_054340300.1XP_054196275.1  nuclear body protein SP140 isoform X5

      UniProtKB/TrEMBL
      Q0VGE4
    7. XM_054340298.1XP_054196273.1  nuclear body protein SP140 isoform X3

      UniProtKB/TrEMBL
      Q0VGE4
    8. XM_054340310.1XP_054196285.1  nuclear body protein SP140 isoform X13

      UniProtKB/TrEMBL
      Q0VGE4
    9. XM_054340306.1XP_054196281.1  nuclear body protein SP140 isoform X9

      UniProtKB/TrEMBL
      Q0VGE4
    10. XM_054340317.1XP_054196292.1  nuclear body protein SP140 isoform X20

      UniProtKB/TrEMBL
      Q0VGE4
    11. XM_054340321.1XP_054196296.1  nuclear body protein SP140 isoform X24

      UniProtKB/TrEMBL
      Q0VGE4
    12. XM_054340313.1XP_054196288.1  nuclear body protein SP140 isoform X16

      UniProtKB/TrEMBL
      B4DVW8
    13. XM_054340316.1XP_054196291.1  nuclear body protein SP140 isoform X19

      UniProtKB/TrEMBL
      B4DVW8
    14. XM_054340325.1XP_054196300.1  nuclear body protein SP140 isoform X28

      UniProtKB/TrEMBL
      Q0VGE4
    15. XM_054340305.1XP_054196280.1  nuclear body protein SP140 isoform X8

      UniProtKB/TrEMBL
      Q0VGE4
    16. XM_054340309.1XP_054196284.1  nuclear body protein SP140 isoform X12

      UniProtKB/TrEMBL
      Q0VGE4
    17. XM_054340323.1XP_054196298.1  nuclear body protein SP140 isoform X26

      UniProtKB/TrEMBL
      Q0VGE4
    18. XM_054340297.1XP_054196272.1  nuclear body protein SP140 isoform X2

      UniProtKB/TrEMBL
      Q0VGE4
    19. XM_054340301.1XP_054196276.1  nuclear body protein SP140 isoform X6

      UniProtKB/TrEMBL
      Q0VGE4
    20. XM_054340299.1XP_054196274.1  nuclear body protein SP140 isoform X4

      UniProtKB/TrEMBL
      Q0VGE4
    21. XM_054340312.1XP_054196287.1  nuclear body protein SP140 isoform X15

      UniProtKB/TrEMBL
      Q0VGE4
    22. XM_054340308.1XP_054196283.1  nuclear body protein SP140 isoform X11

      UniProtKB/TrEMBL
      Q0VGE4
    23. XM_054340320.1XP_054196295.1  nuclear body protein SP140 isoform X23

      UniProtKB/TrEMBL
      Q0VGE4
    24. XM_054340322.1XP_054196297.1  nuclear body protein SP140 isoform X25

      UniProtKB/TrEMBL
      Q0VGE4
    25. XM_054340314.1XP_054196289.1  nuclear body protein SP140 isoform X17

      UniProtKB/TrEMBL
      B4DVW8
    26. XM_054340307.1XP_054196282.1  nuclear body protein SP140 isoform X10

      UniProtKB/TrEMBL
      Q0VGE4
    27. XM_054340311.1XP_054196286.1  nuclear body protein SP140 isoform X14

      UniProtKB/TrEMBL
      Q0VGE4
    28. XM_054340319.1XP_054196294.1  nuclear body protein SP140 isoform X22

      UniProtKB/TrEMBL
      Q0VGE4
    29. XM_054340315.1XP_054196290.1  nuclear body protein SP140 isoform X18

      UniProtKB/TrEMBL
      Q0VGE4
    30. XM_054340324.1XP_054196299.1  nuclear body protein SP140 isoform X27

      UniProtKB/TrEMBL
      Q0VGE4
    31. XM_054340326.1XP_054196301.1  nuclear body protein SP140 isoform X29

    32. XM_054340328.1XP_054196303.1  nuclear body protein SP140 isoform X31

    33. XM_054340327.1XP_054196302.1  nuclear body protein SP140 isoform X30