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    Egln2 egl-9 family hypoxia-inducible factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 112406, updated on 5-Mar-2019

    Summary

    Official Symbol
    Egln2provided by MGI
    Official Full Name
    egl-9 family hypoxia-inducible factor 2provided by MGI
    Primary source
    MGI:MGI:1932287
    See related
    Ensembl:ENSMUSG00000058709
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ier4; Phd1; SM-20; C85656; Hif-p4h-1; 0610011A13Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 271.8), adrenal adult (RPKM 57.2) and 27 other tissues See more
    Orthologs

    Genomic context

    See Egln2 in Genome Data Viewer
    Location:
    7 A3; 7 15.83 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (27158658..27166802, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (27943677..27951821, complement)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 2, subfamily f, polypeptide 2 Neighboring gene cytochrome P450, family 2, subfamily t, polypeptide 4 Neighboring gene RAB4B, member RAS oncogene family Neighboring gene microRNA 3101 Neighboring gene melanoma inhibitory activity

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC101954

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ferrous iron binding ISO
    Inferred from Sequence Orthology
    more info
     
    iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors ISO
    Inferred from Sequence Orthology
    more info
     
    oxygen sensor activity ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-proline 4-dioxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cell redox homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-proline hydroxylation to 4-hydroxy-L-proline ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of neuron apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    egl nine homolog 2
    Names
    HIF-PH1
    HIF-prolyl hydroxylase 1
    HPH-1
    falkor
    hypoxia-inducible factor prolyl hydroxylase 1
    immediate early response 4
    prolyl hydroxylase domain-containing protein 1
    NP_444438.2
    XP_017177418.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357767.1NP_001344696.1  egl nine homolog 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157553
      Conserved Domains (1) summary
      smart00702
      Location:172266
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
    2. NM_053208.4NP_444438.2  egl nine homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_444438.2

      Status: VALIDATED

      Source sequence(s)
      BC086764, BE993075, CB248412
      Consensus CDS
      CCDS21011.1
      UniProtKB/Swiss-Prot
      Q91YE2
      UniProtKB/TrEMBL
      Q80X29
      Related
      ENSMUSP00000078966.4, ENSMUST00000080058.10
      Conserved Domains (1) summary
      smart00702
      Location:217387
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      27158658..27166802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321929.1XP_017177418.1  egl nine homolog 2 isoform X1

      Conserved Domains (1) summary
      smart00702
      Location:172266
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
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