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    SEC63 SEC63 homolog, protein translocation regulator [ Homo sapiens (human) ]

    Gene ID: 11231, updated on 4-Jul-2021

    Summary

    Official Symbol
    SEC63provided by HGNC
    Official Full Name
    SEC63 homolog, protein translocation regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:21082
    See related
    Ensembl:ENSG00000025796 MIM:608648
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERdj2; PCLD2; SEC63L; DNAJC23; PRO2507
    Summary
    The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 36.4), testis (RPKM 22.4) and 25 other tissues See more
    Orthologs
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    Genomic context

    See SEC63 in Genome Data Viewer
    Location:
    6q21
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (107867756..107958208, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (108188960..108279412, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene sine oculis binding protein homolog Neighboring gene Scm polycomb group protein like 4 Neighboring gene RNA, U6 small nuclear 437, pseudogene Neighboring gene ribosomal protein L23a pseudogene 50 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase pseudogene 3 Neighboring gene ribosomal protein L3 pseudogene 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of Sec62/Sec63 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    translocation protein SEC63 homolog
    Names
    SEC63 protein translocation regulator
    SEC63-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008270.1 RefSeqGene

      Range
      5071..95523
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_007214.5NP_009145.1  translocation protein SEC63 homolog

      See identical proteins and their annotated locations for NP_009145.1

      Status: REVIEWED

      Source sequence(s)
      AJ011779, AL024507, BC047221, BM764168, DB049187
      Consensus CDS
      CCDS5061.1
      UniProtKB/Swiss-Prot
      Q9UGP8
      UniProtKB/TrEMBL
      A0A0S2Z5M1
      Related
      ENSP00000357998.4, ENST00000369002.9
      Conserved Domains (2) summary
      smart00611
      Location:209715
      SEC63; Domain of unknown function in Sec63p, Brr2p and other proteins
      pfam00226
      Location:104162
      DnaJ; DnaJ domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      107867756..107958208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017010218.2XP_016865707.1  translocation protein SEC63 homolog isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_018529.1: Suppressed sequence

      Description
      NM_018529.1: This RefSeq was permanently suppressed because it is primarily UTR sequence.
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