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    MRPL3 mitochondrial ribosomal protein L3 [ Homo sapiens (human) ]

    Gene ID: 11222, updated on 5-Aug-2022

    Summary

    Official Symbol
    MRPL3provided by HGNC
    Official Full Name
    mitochondrial ribosomal protein L3provided by HGNC
    Primary source
    HGNC:HGNC:10379
    See related
    Ensembl:ENSG00000114686 MIM:607118; AllianceGenome:HGNC:10379
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MRL3; RPML3; COXPD9
    Summary
    Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 34.3), colon (RPKM 33.4) and 25 other tissues See more
    Orthologs
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    Genomic context

    See MRPL3 in Genome Data Viewer
    Location:
    3q22.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (131462212..131502971, complement)
    110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (134205979..134246719, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (131181056..131221815, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986025 Neighboring gene uncharacterized LOC105374110 Neighboring gene uncharacterized LOC105374114 Neighboring gene small nucleolar RNA, H/ACA box 58 Neighboring gene BCL2 like 12 pseudogene 1 Neighboring gene copine 4 Neighboring gene uncharacterized LOC105374113 Neighboring gene Sharpr-MPRA regulatory region 7150

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial translation IC
    Inferred by Curator
    more info
    PubMed 
    involved_in translation TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    39S ribosomal protein L3, mitochondrial
    Names
    L3mt
    MRP-L3
    mitochondrial 60S ribosomal protein L3
    mitochondrial large ribosomal subunit protein uL3m

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029207.1 RefSeqGene

      Range
      5046..45805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_007208.4NP_009139.1  39S ribosomal protein L3, mitochondrial

      See identical proteins and their annotated locations for NP_009139.1

      Status: REVIEWED

      Source sequence(s)
      BC003375, DC398662, X06323
      Consensus CDS
      CCDS3071.1
      UniProtKB/Swiss-Prot
      P09001, Q6IBT2
      Related
      ENSP00000264995.2, ENST00000264995.8
      Conserved Domains (1) summary
      pfam00297
      Location:3340
      Ribosomal_L3; Ribosomal protein L3

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      131462212..131502971 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      134205979..134246719 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)