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    NUDT6 nudix hydrolase 6 [ Homo sapiens (human) ]

    Gene ID: 11162, updated on 13-Apr-2024

    Summary

    Official Symbol
    NUDT6provided by HGNC
    Official Full Name
    nudix hydrolase 6provided by HGNC
    Primary source
    HGNC:HGNC:8053
    See related
    Ensembl:ENSG00000170917 MIM:606261; AllianceGenome:HGNC:8053
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GFG1; GFG-1; ASFGF2; FGF-AS; FGF2AS
    Summary
    This gene overlaps and lies on the opposite strand from FGF2 gene, and is thought to be the FGF2 antisense gene. The two genes are independently transcribed, and their expression shows an inverse relationship, suggesting that this antisense transcript may regulate FGF2 expression. This gene has also been shown to have hormone-regulatory and antiproliferative actions in the pituitary that are independent of FGF2 expression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
    Expression
    Ubiquitous expression in fat (RPKM 12.5), kidney (RPKM 8.8) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    4q28.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (122892577..122922968, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (126196685..126227087, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (123813732..123844123, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:123767626-123768139 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:123768140-123768652 Neighboring gene ribosomal protein S26 pseudogene 23 Neighboring gene fibroblast growth factor 2 Neighboring gene uncharacterized LOC124900773 Neighboring gene Sharpr-MPRA regulatory region 4593 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:123843896-123844432 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:123865949-123866476 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:123866477-123867003 Neighboring gene AFG2 AAA ATPase homolog A Neighboring gene coilin pseudogene 2 Neighboring gene uncharacterized LOC105377404

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies two novel genomic regions in irritable bowel syndrome.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ADP-ribose diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables NADH pyrophosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    nucleoside diphosphate-linked moiety X motif 6
    Names
    antisense basic fibroblast growth factor
    nudix (nucleoside diphosphate linked moiety X)-type motif 6
    NP_009014.2
    NP_932158.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030404.1 RefSeqGene

      Range
      5408..35428
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_007083.5NP_009014.2  nucleoside diphosphate-linked moiety X motif 6 isoform a

      See identical proteins and their annotated locations for NP_009014.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC021205, AF019633, BC009842, BG386740, CB128685
      Consensus CDS
      CCDS43268.1
      UniProtKB/Swiss-Prot
      A8K756, O95097, P53370, Q9UQD9
      Related
      ENSP00000306070.5, ENST00000304430.10
      Conserved Domains (1) summary
      cd04670
      Location:142275
      Nudix_Hydrolase_12; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
    2. NM_198041.3NP_932158.1  nucleoside diphosphate-linked moiety X motif 6 isoform b

      See identical proteins and their annotated locations for NP_932158.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (b) has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AC021205, AF019632, BC009842
      Consensus CDS
      CCDS3729.1
      UniProtKB/TrEMBL
      B4DG76
      Related
      ENSP00000344011.2, ENST00000339154.6
      Conserved Domains (1) summary
      cl00447
      Location:1106
      Nudix_Hydrolase; Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+ ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      122892577..122922968 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      126196685..126227087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)