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    PMIS2 PMIS2 transmembrane protein [ Homo sapiens (human) ]

    Gene ID: 111216276, updated on 15-Mar-2024

    Summary

    Official Symbol
    PMIS2provided by HGNC
    Official Full Name
    PMIS2 transmembrane proteinprovided by HGNC
    Primary source
    HGNC:HGNC:53649
    See related
    Ensembl:ENSG00000283758 AllianceGenome:HGNC:53649
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IFITMD9
    Summary
    Predicted to act upstream of or within binding activity of sperm to zona pellucida. Predicted to be integral component of membrane. Predicted to be active in intracellular membrane-bounded organelle and membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    See PMIS2 in Genome Data Viewer
    Location:
    19q13.12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35586161..35587296)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (38131114..38132249)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (36077063..36078198)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATPase H+/K+ transporting subunit alpha Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14484 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:36048997-36049612 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14485 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:36055715-36056216 Neighboring gene uncharacterized LOC124904704 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14486 Neighboring gene long intergenic non-protein coding RNA 1766 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:36103371-36103926 Neighboring gene HAUS5 divergent transcript

    Genomic regions, transcripts, and products

    General protein information

    Preferred Names
    transmembrane protein PMIS2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395411.1NP_001382340.1  transmembrane protein PMIS2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC002115
      Consensus CDS
      CCDS92591.1
      UniProtKB/TrEMBL
      A0A2R8YHA6
      Related
      ENSP00000496617.1, ENST00000646476.1
      Conserved Domains (1) summary
      PRK12270
      Location:260
      kgd; multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit
    2. NM_001395412.1NP_001382341.1  transmembrane protein PMIS2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC002115
      Consensus CDS
      CCDS92590.1
      UniProtKB/Swiss-Prot
      A0A1W2PS18
      Related
      ENSP00000492557.1, ENST00000640449.2
      Conserved Domains (2) summary
      pfam04505
      Location:68145
      CD225; Interferon-induced transmembrane protein
      NF033913
      Location:462
      fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      35586161..35587296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      38131114..38132249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)