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    Rpl10 ribosomal protein L10 [ Mus musculus (house mouse) ]

    Gene ID: 110954, updated on 5-Mar-2024

    Summary

    Official Symbol
    Rpl10provided by MGI
    Official Full Name
    ribosomal protein L10provided by MGI
    Primary source
    MGI:MGI:105943
    See related
    Ensembl:ENSMUSG00000008682 AllianceGenome:MGI:105943
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    QM; QM16; D0HXS648; DXHXS648; DXHXS648E
    Summary
    Predicted to enable translation regulator activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in several processes, including embryonic brain development; regulation of cellular macromolecule biosynthetic process; and ribosomal large subunit assembly. Predicted to act upstream of or within translation. Located in cytoplasm. Is active in synapse. Colocalizes with smooth endoplasmic reticulum. Is expressed in several structures, including limb; nervous system; otocyst; skin; and surface ectoderm. Human ortholog(s) of this gene implicated in autistic disorder and syndromic X-linked mental retardation 35. Orthologous to human RPL10 (ribosomal protein L10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 662.4), genital fat pad adult (RPKM 624.3) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Rpl10 in Genome Data Viewer
    Location:
    X A7.3; X 37.94 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (73314463..73316741)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (74270816..74273135)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene filamin, alpha Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:71489308-71489552 Neighboring gene emerin Neighboring gene eukaryotic translation initiation factor 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47366 Neighboring gene deoxyribonuclease 1-like 1 Neighboring gene small nucleolar RNA, H/ACA box 70 Neighboring gene microRNA 7091 Neighboring gene predicted gene 14846

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC107630

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    enables translation regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in embryonic brain development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosomal large subunit assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in translation at postsynapse NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in translation at presynapse NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in postsynapse NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in presynapse NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    colocalizes_with smooth endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with smooth endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    large ribosomal subunit protein uL16
    Names
    24.6 kDa protein
    24.6kDa protein
    60S ribosomal protein L10
    protein QM homolog
    ribosomal protein 10
    NP_443067.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_052835.4NP_443067.1  large ribosomal subunit protein uL16

      See identical proteins and their annotated locations for NP_443067.1

      Status: VALIDATED

      Source sequence(s)
      AL807376
      Consensus CDS
      CCDS41019.1
      UniProtKB/Swiss-Prot
      P45634, Q569M8, Q5M9K8, Q6ZWV3
      UniProtKB/TrEMBL
      A2AM97, Q3THJ6
      Related
      ENSMUSP00000008826.8, ENSMUST00000008826.14
      Conserved Domains (1) summary
      PTZ00173
      Location:1209
      PTZ00173; 60S ribosomal protein L10; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      73314463..73316741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)