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    Ptpa protein phosphatase 2 protein activator [ Mus musculus (house mouse) ]

    Gene ID: 110854, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ptpaprovided by MGI
    Official Full Name
    protein phosphatase 2 protein activatorprovided by MGI
    Primary source
    MGI:MGI:1346006
    See related
    Ensembl:ENSMUSG00000039515 AllianceGenome:MGI:1346006
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PR53; Ppp2r4; 2610042B21Rik
    Summary
    Predicted to enable several functions, including ATP binding activity; protein homodimerization activity; and protein phosphatase 2A binding activity. Predicted to contribute to phosphoprotein phosphatase activity. Predicted to be involved in mitotic spindle organization and positive regulation of apoptotic process. Predicted to be located in nucleoplasm. Predicted to be part of ATPase complex; calcium channel complex; and protein phosphatase type 2A complex. Predicted to be active in cytoplasm and nucleus. Is expressed in embryo and forelimb bud. Human ortholog(s) of this gene implicated in Parkinson's disease 25. Orthologous to human PTPA (protein phosphatase 2 phosphatase activator). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 63.8), liver E14.5 (RPKM 52.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ptpa in Genome Data Viewer
    Location:
    2 B; 2 21.71 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30306062..30337819)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30416050..30447807)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene mitoguardin 2 Neighboring gene STARR-positive B cell enhancer ABC_E410 Neighboring gene dolichyl pyrophosphate phosphatase 1 Neighboring gene carnitine acetyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E5903 Neighboring gene STARR-seq mESC enhancer starr_04096 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:30319437-30319638 Neighboring gene STARR-positive B cell enhancer ABC_E1584 Neighboring gene STARR-positive B cell enhancer ABC_E3367 Neighboring gene predicted gene, 31291 Neighboring gene immediate early response 5-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC7129, MGC60706

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to phosphoprotein phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to phosphoprotein phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase 2A binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein tyrosine phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine phosphatase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of ATPase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of calcium channel complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protein phosphatase type 2A complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein phosphatase type 2A complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 2A activator
    Names
    phosphotyrosyl phosphatase activator
    protein phosphatase 2A activator, regulatory subunit B
    protein phosphatase 2A, regulatory subunit B (PR 53)
    serine/threonine-protein phosphatase 2A regulatory subunit 4
    serine/threonine-protein phosphatase 2A regulatory subunit B'
    NP_001349662.1
    NP_001349663.1
    NP_620087.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362733.1NP_001349662.1  serine/threonine-protein phosphatase 2A activator isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL954299
      UniProtKB/TrEMBL
      Q8C0E1
      Conserved Domains (1) summary
      pfam03095
      Location:26319
      PTPA; Phosphotyrosyl phosphate activator (PTPA) protein
    2. NM_001362734.1NP_001349663.1  serine/threonine-protein phosphatase 2A activator isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL954299
      Conserved Domains (1) summary
      pfam03095
      Location:26229
      PTPA; Phosphotyrosyl phosphate activator (PTPA) protein
    3. NM_138748.5NP_620087.3  serine/threonine-protein phosphatase 2A activator isoform 2

      See identical proteins and their annotated locations for NP_620087.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK049184, AL954299
      Consensus CDS
      CCDS15883.1
      UniProtKB/Swiss-Prot
      P58389
      UniProtKB/TrEMBL
      Q543N6, Q8C0E1
      Related
      ENSMUSP00000046837.4, ENSMUST00000042055.10
      Conserved Domains (1) summary
      pfam03095
      Location:26316
      PTPA; Phosphotyrosyl phosphate activator (PTPA) protein

    RNA

    1. NR_156126.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL954299
    2. NR_156127.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL954299, CX221557

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      30306062..30337819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)