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    Ptpa protein phosphatase 2 protein activator [ Mus musculus (house mouse) ]

    Gene ID: 110854, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ptpaprovided by MGI
    Official Full Name
    protein phosphatase 2 protein activatorprovided by MGI
    Primary source
    MGI:MGI:1346006
    See related
    Ensembl:ENSMUSG00000039515
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pp; PR53; C77440; N28142; Ppp2r4; 2610042B21Rik
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 63.8), liver E14.5 (RPKM 52.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ptpa in Genome Data Viewer
    Location:
    2 B; 2 21.71 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30306062..30337819)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30416050..30447807)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (30271570..30303327)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene mitoguardin 2 Neighboring gene dolichyl pyrophosphate phosphatase 1 Neighboring gene carnitine acetyltransferase Neighboring gene predicted gene, 31291 Neighboring gene immediate early response 5-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC7129, MGC60706

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphatase activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase 2A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein phosphatase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine phosphatase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein tyrosine phosphatase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of calcium channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein phosphatase type 2A complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of protein phosphatase type 2A complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 2A activator
    Names
    phosphotyrosyl phosphatase activator
    protein phosphatase 2A activator, regulatory subunit B
    protein phosphatase 2A, regulatory subunit B (PR 53)
    serine/threonine-protein phosphatase 2A regulatory subunit 4
    serine/threonine-protein phosphatase 2A regulatory subunit B'
    NP_001349662.1
    NP_001349663.1
    NP_620087.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362733.1NP_001349662.1  serine/threonine-protein phosphatase 2A activator isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL954299
      Conserved Domains (1) summary
      pfam03095
      Location:26319
      PTPA; Phosphotyrosyl phosphate activator (PTPA) protein
    2. NM_001362734.1NP_001349663.1  serine/threonine-protein phosphatase 2A activator isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL954299
      Conserved Domains (1) summary
      pfam03095
      Location:26229
      PTPA; Phosphotyrosyl phosphate activator (PTPA) protein
    3. NM_138748.5NP_620087.3  serine/threonine-protein phosphatase 2A activator isoform 2

      See identical proteins and their annotated locations for NP_620087.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AK049184, AL954299
      Consensus CDS
      CCDS15883.1
      UniProtKB/Swiss-Prot
      P58389
      UniProtKB/TrEMBL
      Q543N6
      Related
      ENSMUSP00000046837.4, ENSMUST00000042055.10
      Conserved Domains (1) summary
      pfam03095
      Location:26316
      PTPA; Phosphotyrosyl phosphate activator (PTPA) protein

    RNA

    1. NR_156126.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL954299
    2. NR_156127.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL954299, CX221557

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      30306062..30337819
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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