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    Pcca propionyl-Coenzyme A carboxylase, alpha polypeptide [ Mus musculus (house mouse) ]

    Gene ID: 110821, updated on 22-Aug-2021

    Summary

    Official Symbol
    Pccaprovided by MGI
    Official Full Name
    propionyl-Coenzyme A carboxylase, alpha polypeptideprovided by MGI
    Primary source
    MGI:MGI:97499
    See related
    Ensembl:ENSMUSG00000041650
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C79630
    Expression
    Ubiquitous expression in kidney adult (RPKM 4.2), liver E18 (RPKM 3.6) and 25 other tissues See more
    Orthologs
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    Genomic context

    See Pcca in Genome Data Viewer
    Location:
    14 E5; 14 65.99 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (122721752..123127356)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (122484365..122889944)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (122933550..123289166)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33769 Neighboring gene zinc finger protein of the cerebellum 2 Neighboring gene PRELI domain containing 1 pseudogene Neighboring gene asparagine synthetase pseudogene Neighboring gene predicted gene, 46487 Neighboring gene predicted gene, 53848 Neighboring gene RIKEN cDNA 4930594M22 gene Neighboring gene gamma-glutamylamine cyclotransferase Neighboring gene predicted gene, 46488 Neighboring gene transmembrane and tetratricopeptide repeat containing 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables propionyl-CoA carboxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables propionyl-CoA carboxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables propionyl-CoA carboxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    propionyl-CoA carboxylase alpha chain, mitochondrial
    Names
    PCCase subunit alpha
    propanoyl-CoA:carbon dioxide ligase subunit alpha
    propionyl CoA-carboxylase alpha
    NP_659093.2
    XP_006518493.1
    XP_006518495.1
    XP_036014292.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144844.2NP_659093.2  propionyl-CoA carboxylase alpha chain, mitochondrial precursor

      See identical proteins and their annotated locations for NP_659093.2

      Status: VALIDATED

      Source sequence(s)
      AK148002, BY263345
      Consensus CDS
      CCDS27350.1
      UniProtKB/Swiss-Prot
      Q91ZA3
      UniProtKB/TrEMBL
      Q3UGC8
      Related
      ENSMUSP00000038763.7, ENSMUST00000038374.13
      Conserved Domains (5) summary
      cd06850
      Location:657723
      biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
      smart00878
      Location:393500
      Biotin_carb_C; Biotin carboxylase C-terminal domain
      COG4770
      Location:59724
      PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]
      pfam00289
      Location:59167
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam02786
      Location:172379
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

    RNA

    1. NR_153443.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154683, AC169511, AK148002

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      122721752..123127356
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006518432.4XP_006518495.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X2

      Conserved Domains (1) summary
      cl39082
      Location:1644
      PycA; Pyruvate carboxylase [Energy production and conversion]
    2. XM_006518430.5XP_006518493.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X1

      Conserved Domains (1) summary
      COG4770
      Location:59706
      PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]
    3. XM_036158399.1XP_036014292.1  propionyl-CoA carboxylase alpha chain, mitochondrial isoform X3

    RNA

    1. XR_004938364.1 RNA Sequence

    2. XR_383133.4 RNA Sequence

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