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    DNAJB4 DnaJ heat shock protein family (Hsp40) member B4 [ Homo sapiens (human) ]

    Gene ID: 11080, updated on 7-Apr-2024

    Summary

    Official Symbol
    DNAJB4provided by HGNC
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B4provided by HGNC
    Primary source
    HGNC:HGNC:14886
    See related
    Ensembl:ENSG00000162616 MIM:611327; AllianceGenome:HGNC:14886
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DjB4; HLJ1; DNAJW; CMYP21
    Summary
    The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
    Expression
    Ubiquitous expression in adrenal (RPKM 27.3), thyroid (RPKM 23.6) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See DNAJB4 in Genome Data Viewer
    Location:
    1p31.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (77979175..78017964)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (77817970..77856789)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (78444859..78483648)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene mitoguardin 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:78336231-78337101 Neighboring gene heat shock protein family E (Hsp10) member 1 pseudogene 25 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1222 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1005 Neighboring gene NEXN antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:78374978-78375131 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:78383688-78384887 Neighboring gene nexilin F-actin binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1006 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:78431300-78431502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1223 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1225 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1224 Neighboring gene far upstream element binding protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1227 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1228 Neighboring gene nitrilase family member 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1230 Neighboring gene GIPC PDZ domain containing family member 2 Neighboring gene RNA, U6 small nuclear 1102, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat downregulates the expression of DnaJ (Hsp40) homolog, subfamily B, member 4 (DNAJB4) in human primary T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to heat TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in response to unfolded protein TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    dnaJ homolog subfamily B member 4
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 4
    DnaJ-like heat shock protein 40
    HSP40 homolog
    heat shock 40 kDa protein 1 homolog
    heat shock protein 40 homolog
    human liver DnaJ-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317099.2NP_001304028.1  dnaJ homolog subfamily B member 4 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC096948, AC103591, BC034721, BI831822, BM972589
      Consensus CDS
      CCDS684.1
      UniProtKB/Swiss-Prot
      B2R824, Q13431, Q9UDY4
      UniProtKB/TrEMBL
      Q59E89
      Conserved Domains (1) summary
      COG0484
      Location:1332
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    2. NM_001317100.2NP_001304029.1  dnaJ homolog subfamily B member 4 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AC103591, BC034721, BM972589, BX441874, CN270601, DC349099, DC412631
      UniProtKB/Swiss-Prot
      Q9UDY4
      Conserved Domains (1) summary
      cd10747
      Location:118282
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    3. NM_001317101.2NP_001304030.1  dnaJ homolog subfamily B member 4 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (c).
      Source sequence(s)
      AC103591, BC034721, BM972589, BX441874, CN355216, DC412631
      UniProtKB/TrEMBL
      B4DNN2
      Conserved Domains (1) summary
      cd10747
      Location:43207
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    4. NM_001317102.2NP_001304031.1  dnaJ homolog subfamily B member 4 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 4 and 5 both encode the same isoform (c).
      Source sequence(s)
      AC103591, BC034721, BM972589, DC412631
      UniProtKB/TrEMBL
      B4DNN2
      Conserved Domains (1) summary
      cd10747
      Location:43207
      DnaJ_C; C-terminal substrate binding domain of DnaJ and HSP40
    5. NM_001317103.2NP_001304032.1  dnaJ homolog subfamily B member 4 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (d) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC103591, BC034721, BI910092, BM972589, DA473487
      UniProtKB/Swiss-Prot
      Q9UDY4
      Conserved Domains (1) summary
      cl28246
      Location:471
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    6. NM_007034.5NP_008965.2  dnaJ homolog subfamily B member 4 isoform a

      See identical proteins and their annotated locations for NP_008965.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC103591, BC034721, BM972589, DA354925
      Consensus CDS
      CCDS684.1
      UniProtKB/Swiss-Prot
      B2R824, Q13431, Q9UDY4
      UniProtKB/TrEMBL
      Q59E89
      Related
      ENSP00000359799.5, ENST00000370763.6
      Conserved Domains (1) summary
      COG0484
      Location:1332
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      77979175..78017964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      77817970..77856789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)