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    RAPGEF4 Rap guanine nucleotide exchange factor 4 [ Homo sapiens (human) ]

    Gene ID: 11069, updated on 17-Jun-2024

    Summary

    Official Symbol
    RAPGEF4provided by HGNC
    Official Full Name
    Rap guanine nucleotide exchange factor 4provided by HGNC
    Primary source
    HGNC:HGNC:16626
    See related
    Ensembl:ENSG00000091428 MIM:606058; AllianceGenome:HGNC:16626
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EPAC; CGEF2; EPAC2; EPAC 2; Nbla00496; CAMP-GEFII
    Summary
    Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane and regulation of postsynapse organization. Predicted to act upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of exocytosis; and secretion by cell. Predicted to be located in plasma membrane. Predicted to be active in glutamatergic synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density. Implicated in autistic disorder. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in brain (RPKM 37.0), adrenal (RPKM 17.3) and 12 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RAPGEF4 in Genome Data Viewer
    Location:
    2q31.1
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (172735318..173052893)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (173221758..173539439)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (173600573..173917621)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56072 Neighboring gene integrin subunit alpha 6 Neighboring gene PDK1 and ITGA6 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 994 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:173399678-173400178 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:173413559-173414301 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:173414302-173415043 Neighboring gene Sharpr-MPRA regulatory region 4236 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16763 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12111 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:173456666-173456873 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56189 Neighboring gene pyruvate dehydrogenase kinase 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56221 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56231 Neighboring gene Sharpr-MPRA regulatory region 7042 Neighboring gene small nucleolar RNA U13 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56260 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56279 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56293 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:173577807-173578364 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:173590766-173591266 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:173591267-173591767 Neighboring gene RAPGEF4 antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:173607526-173608725 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:173668092-173668282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:173770903-173771408 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:173771409-173771912 Neighboring gene aldehyde dehydrogenase 7 family member A1 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12112 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12113 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56377 Neighboring gene mitogen-activated protein kinase kinase kinase 20 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_56397 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:174056283-174056864 Neighboring gene MAP3K20 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16764 Neighboring gene VISTA enhancer hs242 Neighboring gene NANOG hESC enhancer GRCh37_chr2:174129200-174129707 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16765 Neighboring gene uncharacterized LOC105373743

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association meta-analysis identifies novel variants associated with fasting plasma glucose in East Asians.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag Prostaglandin E2-mediated HIV-1 inhibition requires the EPAC/RAP/RhoA signaling pathway by downregulation of HIV-1 CA production PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cAMP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables guanyl-nucleotide exchange factor activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adaptive immune response TAS
    Traceable Author Statement
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium-ion regulated exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of synaptic vesicle cycle IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in hippocampal mossy fiber to CA3 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    rap guanine nucleotide exchange factor 4
    Names
    RAP guanine-nucleotide-exchange factor (GEF) 4
    Rap guanine nucleotide exchange factor (GEF) 4
    cAMP-regulated guanine nucleotide exchange factor II
    exchange factor directly activated by cAMP 2
    exchange protein directly activated by cAMP 2
    putative protein product of Nbla00496

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100397.2NP_001093867.1  rap guanine nucleotide exchange factor 4 isoform b

      See identical proteins and their annotated locations for NP_001093867.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in its 5' UTR, lacks several exons in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
      Source sequence(s)
      AC009484, AC019046, AC104086
      Consensus CDS
      CCDS42776.1
      UniProtKB/TrEMBL
      B7Z9P9
      Related
      ENSP00000380276.3, ENST00000397087.7
      Conserved Domains (4) summary
      smart00147
      Location:624865
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:212323
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:62190
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:355461
      RasGEF_N; RasGEF N-terminal motif
    2. NM_001282899.2NP_001269828.1  rap guanine nucleotide exchange factor 4 isoform c

      See identical proteins and their annotated locations for NP_001269828.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in its 5' UTR, lacks several exons in the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AC009484, AC019046, AC104086
      Consensus CDS
      CCDS63060.1
      UniProtKB/TrEMBL
      B7Z9P9
      Related
      ENSP00000440250.1, ENST00000540783.5
      Conserved Domains (4) summary
      smart00147
      Location:615856
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:203314
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:53181
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:346452
      RasGEF_N; RasGEF N-terminal motif
    3. NM_001282900.2NP_001269829.1  rap guanine nucleotide exchange factor 4 isoform d

      See identical proteins and their annotated locations for NP_001269829.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in its 5' UTR, lacks several exons in the 5' coding region, initiates translation at a downstream in-frame start codon, and lacks an additional in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (d) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AC009484, AC019046, AC104086
      Consensus CDS
      CCDS63061.1
      UniProtKB/TrEMBL
      B7Z9P9
      Related
      ENSP00000440135.1, ENST00000538974.5
      Conserved Domains (4) summary
      smart00147
      Location:597838
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:185296
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:35163
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:328434
      RasGEF_N; RasGEF N-terminal motif
    4. NM_001282901.2NP_001269830.1  rap guanine nucleotide exchange factor 4 isoform e

      See identical proteins and their annotated locations for NP_001269830.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in its 5' UTR, lacks several exons in the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (e) is shorter at the N-terminus, compared to isoform a.
      Source sequence(s)
      AC009484, AC019046, AC104086
      Consensus CDS
      CCDS74604.1
      UniProtKB/TrEMBL
      B7Z278, B7Z9P9
      Related
      ENSP00000438011.1, ENST00000535187.5
      Conserved Domains (4) summary
      smart00147
      Location:548789
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:136247
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:1114
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:279385
      RasGEF_N; RasGEF N-terminal motif
    5. NM_001375864.1NP_001362793.1  rap guanine nucleotide exchange factor 4 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC009484, AC018712, AC019046, AC104086
      UniProtKB/TrEMBL
      X5D9F4
      Conserved Domains (4) summary
      cd06224
      Location:494619
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:758999
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:33148
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:196324
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    6. NM_001375865.1NP_001362794.1  rap guanine nucleotide exchange factor 4 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC009484, AC018712, AC019046, AC104086
      UniProtKB/TrEMBL
      X5D9F4
      Conserved Domains (4) summary
      smart00147
      Location:757998
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:43158
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:206334
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:499605
      RasGEF_N; RasGEF N-terminal motif
    7. NM_001375866.1NP_001362795.1  rap guanine nucleotide exchange factor 4 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC009484, AC018712, AC019046, AC104086
      UniProtKB/TrEMBL
      X5D7N4, X5D9F4
      Conserved Domains (4) summary
      smart00147
      Location:750991
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:43158
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:188316
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:481587
      RasGEF_N; RasGEF N-terminal motif
    8. NM_001375867.1NP_001362796.1  rap guanine nucleotide exchange factor 4 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC009484, AC018712, AC019046, AC104086
      UniProtKB/TrEMBL
      X5D9F4
      Conserved Domains (4) summary
      smart00147
      Location:737978
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:325436
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:175303
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:468574
      RasGEF_N; RasGEF N-terminal motif
    9. NM_001375868.1NP_001362797.1  rap guanine nucleotide exchange factor 4 isoform j

      Status: VALIDATED

      Source sequence(s)
      AC009484, AC018712, AC019046, AC104086
      UniProtKB/TrEMBL
      X5D9F4
      Conserved Domains (4) summary
      smart00147
      Location:719960
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:43158
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:206334
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:499605
      RasGEF_N; RasGEF N-terminal motif
    10. NM_001375869.1NP_001362798.1  rap guanine nucleotide exchange factor 4 isoform k

      Status: VALIDATED

      Source sequence(s)
      AC009484, AC018712, AC019046, AC104086
      UniProtKB/TrEMBL
      X5D9F4
      Conserved Domains (4) summary
      smart00147
      Location:768958
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:43158
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:206334
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:499605
      RasGEF_N; RasGEF N-terminal motif
    11. NM_001375870.1NP_001362799.1  rap guanine nucleotide exchange factor 4 isoform l

      Status: VALIDATED

      Source sequence(s)
      AC009484, AC018712, AC019046, AC104086
      UniProtKB/TrEMBL
      X5D9F4
      Conserved Domains (4) summary
      smart00147
      Location:768929
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:43158
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:206334
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:499605
      RasGEF_N; RasGEF N-terminal motif
    12. NM_001375871.1NP_001362800.1  rap guanine nucleotide exchange factor 4 isoform m

      Status: VALIDATED

      Source sequence(s)
      AC009484, AC018712, AC019046, AC104086
      UniProtKB/TrEMBL
      X5D9F4
      Conserved Domains (4) summary
      smart00147
      Location:701942
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:43158
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:188316
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:481587
      RasGEF_N; RasGEF N-terminal motif
    13. NM_001375872.1NP_001362801.1  rap guanine nucleotide exchange factor 4 isoform n

      Status: VALIDATED

      Source sequence(s)
      AC009484, AC018712, AC019046, AC104086
      Consensus CDS
      CCDS92899.1
      UniProtKB/TrEMBL
      E9PB94, X5D9F4
      Related
      ENSP00000387104.1, ENST00000409036.5
      Conserved Domains (4) summary
      smart00147
      Location:768941
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:43158
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:206334
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:499605
      RasGEF_N; RasGEF N-terminal motif
    14. NM_001375873.1NP_001362802.1  rap guanine nucleotide exchange factor 4 isoform o

      Status: VALIDATED

      Source sequence(s)
      AC009484, AC018712, AC019046, AC104086
      UniProtKB/TrEMBL
      X5D9F4
      Conserved Domains (4) summary
      smart00147
      Location:750940
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:43158
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:188316
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:481587
      RasGEF_N; RasGEF N-terminal motif
    15. NM_001375874.1NP_001362803.1  rap guanine nucleotide exchange factor 4 isoform p

      Status: VALIDATED

      Source sequence(s)
      AC009484, AC018712, AC019046, AC104086
      UniProtKB/TrEMBL
      X5D9F4
      Conserved Domains (4) summary
      smart00147
      Location:750911
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:43158
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:188316
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:481587
      RasGEF_N; RasGEF N-terminal motif
    16. NM_001375875.1NP_001362804.1  rap guanine nucleotide exchange factor 4 isoform q

      Status: VALIDATED

      Source sequence(s)
      AC009484, AC018712, AC104086
      UniProtKB/TrEMBL
      B7Z2Q8
      Conserved Domains (2) summary
      cd00038
      Location:43158
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:206334
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    17. NM_001375876.1NP_001362805.1  rap guanine nucleotide exchange factor 4 isoform r

      Status: VALIDATED

      Source sequence(s)
      AC009484, AC018712, AC104086
      Conserved Domains (2) summary
      cd00038
      Location:43158
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:188316
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
    18. NM_007023.4NP_008954.2  rap guanine nucleotide exchange factor 4 isoform a

      See identical proteins and their annotated locations for NP_008954.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC009484, AC018712, AC019046, AC104086
      Consensus CDS
      CCDS42775.1
      UniProtKB/Swiss-Prot
      B2R7R3, B7Z283, B7Z3T6, B7Z912, O95636, Q8IXK6, Q8TAA4, Q8WZA2
      UniProtKB/TrEMBL
      X5D9F4
      Related
      ENSP00000380271.3, ENST00000397081.8
      Conserved Domains (4) summary
      smart00147
      Location:7681009
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:43158
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:206334
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:499605
      RasGEF_N; RasGEF N-terminal motif

    RNA

    1. NR_164739.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009484, AC018712, AC019046, AC104086
    2. NR_164740.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009484, AC018712, AC019046, AC104086
    3. NR_164741.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC009484, AC018712, AC019046, AC104086

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      172735318..173052893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047443030.1XP_047298986.1  rap guanine nucleotide exchange factor 4 isoform X4

      UniProtKB/TrEMBL
      B7Z9P9
    2. XM_006712205.4XP_006712268.1  rap guanine nucleotide exchange factor 4 isoform X6

      See identical proteins and their annotated locations for XP_006712268.1

      UniProtKB/TrEMBL
      B7Z9P9
      Conserved Domains (4) summary
      smart00147
      Location:597838
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd00038
      Location:185296
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      cd04437
      Location:35163
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
      pfam00618
      Location:328434
      RasGEF_N; RasGEF N-terminal motif
    3. XM_017003196.3XP_016858685.1  rap guanine nucleotide exchange factor 4 isoform X1

      UniProtKB/TrEMBL
      X5D9F4
    4. XM_047443028.1XP_047298984.1  rap guanine nucleotide exchange factor 4 isoform X2

      UniProtKB/TrEMBL
      B7Z9P9
    5. XM_017003197.2XP_016858686.1  rap guanine nucleotide exchange factor 4 isoform X5

      UniProtKB/TrEMBL
      B7Z9P9
    6. XM_047443029.1XP_047298985.1  rap guanine nucleotide exchange factor 4 isoform X3

      UniProtKB/TrEMBL
      B7Z9P9
    7. XM_047443032.1XP_047298988.1  rap guanine nucleotide exchange factor 4 isoform X8

      UniProtKB/TrEMBL
      B7Z9P9
    8. XM_047443033.1XP_047298989.1  rap guanine nucleotide exchange factor 4 isoform X9

      UniProtKB/TrEMBL
      B7Z278, B7Z9P9
    9. XM_047443031.1XP_047298987.1  rap guanine nucleotide exchange factor 4 isoform X7

      UniProtKB/TrEMBL
      B7Z9P9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      173221758..173539439
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340254.1XP_054196229.1  rap guanine nucleotide exchange factor 4 isoform X4

      UniProtKB/TrEMBL
      B7Z9P9
    2. XM_054340256.1XP_054196231.1  rap guanine nucleotide exchange factor 4 isoform X6

      UniProtKB/TrEMBL
      B7Z9P9
    3. XM_054340251.1XP_054196226.1  rap guanine nucleotide exchange factor 4 isoform X1

      UniProtKB/TrEMBL
      X5D9F4
    4. XM_054340252.1XP_054196227.1  rap guanine nucleotide exchange factor 4 isoform X2

      UniProtKB/TrEMBL
      B7Z9P9
    5. XM_054340255.1XP_054196230.1  rap guanine nucleotide exchange factor 4 isoform X5

      UniProtKB/TrEMBL
      B7Z9P9
    6. XM_054340253.1XP_054196228.1  rap guanine nucleotide exchange factor 4 isoform X3

      UniProtKB/TrEMBL
      B7Z9P9
    7. XM_054340258.1XP_054196233.1  rap guanine nucleotide exchange factor 4 isoform X8

      UniProtKB/TrEMBL
      B7Z9P9
    8. XM_054340257.1XP_054196232.1  rap guanine nucleotide exchange factor 4 isoform X7

      UniProtKB/TrEMBL
      B7Z9P9
    9. XM_054340259.1XP_054196234.1  rap guanine nucleotide exchange factor 4 isoform X9

      UniProtKB/TrEMBL
      B7Z278, B7Z9P9