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    Acat1 acetyl-Coenzyme A acetyltransferase 1 [ Mus musculus (house mouse) ]

    Gene ID: 110446, updated on 23-Jun-2021

    Summary

    Official Symbol
    Acat1provided by MGI
    Official Full Name
    acetyl-Coenzyme A acetyltransferase 1provided by MGI
    Primary source
    MGI:MGI:87870
    See related
    Ensembl:ENSMUSG00000032047
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ac; Acat; 6330585C21Rik
    Expression
    Broad expression in liver E18 (RPKM 193.6), heart adult (RPKM 69.0) and 20 other tissues See more
    Orthologs
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    Genomic context

    See Acat1 in Genome Data Viewer
    Location:
    9 A5.3; 9 29.12 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (53491822..53521650, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (53580522..53610350, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (53388627..53418455, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene ataxia telangiectasia mutated Neighboring gene nuclear protein in the AT region Neighboring gene cullin 5 Neighboring gene predicted gene, 22304 Neighboring gene predicted gene 16124

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acetyl-CoA C-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables acetyl-CoA C-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables acetyl-CoA C-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
    Inferred from Electronic Annotation
    more info
     
    enables coenzyme A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables potassium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in acetyl-CoA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in acetyl-CoA catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in coenzyme A biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in coenzyme A metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within fatty acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in isoleucine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ketone body catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in propionyl-CoA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane HDA PubMed 
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    acetyl-CoA acetyltransferase, mitochondrial
    Names
    acetoacetyl-CoA thiolase
    NP_659033.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144784.3NP_659033.1  acetyl-CoA acetyltransferase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_659033.1

      Status: VALIDATED

      Source sequence(s)
      AC156640
      Consensus CDS
      CCDS23184.1
      UniProtKB/Swiss-Prot
      Q8QZT1
      Related
      ENSMUSP00000034547.6, ENSMUST00000034547.6
      Conserved Domains (2) summary
      PLN02644
      Location:38424
      PLN02644; acetyl-CoA C-acetyltransferase
      cd00751
      Location:40423
      thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      53491822..53521650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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