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    RCC1 regulator of chromosome condensation 1 [ Homo sapiens (human) ]

    Gene ID: 1104, updated on 5-Jan-2022

    Summary

    Official Symbol
    RCC1provided by HGNC
    Official Full Name
    regulator of chromosome condensation 1provided by HGNC
    Primary source
    HGNC:HGNC:1913
    See related
    Ensembl:ENSG00000180198 MIM:179710
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CHC1; RCC1-I
    Summary
    Enables several functions, including guanyl-nucleotide exchange factor activity; nucleosomal DNA binding activity; and protein heterodimerization activity. Involved in several processes, including G1/S transition of mitotic cell cycle; regulation of mitotic nuclear division; and spindle organization. Located in chromatin; cytoplasm; and nucleus. Part of protein-containing complex. [provided by Alliance of Genome Resources, Nov 2021]
    Expression
    Ubiquitous expression in testis (RPKM 13.1), lymph node (RPKM 11.7) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RCC1 in Genome Data Viewer
    Location:
    1p35.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (28506043..28538989)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (28832555..28865501)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene phosphatase and actin regulator 4 Neighboring gene Sharpr-MPRA regulatory region 2241 Neighboring gene RNA, U6atac small nuclear 27, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7965 Neighboring gene small nucleolar RNA, H/ACA box 73A Neighboring gene small nucleolar RNA, H/ACA box 73B Neighboring gene small nucleolar RNA host gene 3 Neighboring gene peroxiredoxin 3 pseudogene 2 Neighboring gene Sharpr-MPRA regulatory region 11844 Neighboring gene Sharpr-MPRA regulatory region 11894 Neighboring gene tRNA selenocysteine 1 associated protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human regulator of chromosome condensation 1 (RCC1) at amino acid residues 38-39 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough RCC1

    Included gene: SNHG3

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
     
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleosomal DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleosome binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables sulfate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic nuclear membrane reassembly TAS
    Traceable Author Statement
    more info
     
    involved_in mitotic spindle organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitotic nuclear division IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in viral process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome TAS
    Traceable Author Statement
    more info
     
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    regulator of chromosome condensation
    Names
    cell cycle regulatory protein
    guanine nucleotide-releasing protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001048194.4NP_001041659.1  regulator of chromosome condensation isoform a

      See identical proteins and their annotated locations for NP_001041659.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AL513497, BC069198, BF590413, X12654
      Consensus CDS
      CCDS41295.1
      UniProtKB/Swiss-Prot
      P18754
      UniProtKB/TrEMBL
      A0A0S2Z404
      Related
      ENSP00000362937.3, ENST00000373831.7
      Conserved Domains (1) summary
      pfam00415
      Location:394445
      RCC1; Regulator of chromosome condensation (RCC1) repeat
    2. NM_001048195.4NP_001041660.1  regulator of chromosome condensation isoform b

      See identical proteins and their annotated locations for NP_001041660.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
      Source sequence(s)
      AL513497, BF590413, BM546148, BQ436549, X12654
      UniProtKB/Swiss-Prot
      P18754
      UniProtKB/TrEMBL
      A0A0S2Z3I4
      Related
      ENSP00000413644.1, ENST00000411533.5
      Conserved Domains (2) summary
      COG5184
      Location:21435
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00415
      Location:380431
      RCC1; Regulator of chromosome condensation (RCC1) repeat
    3. NM_001048199.3NP_001041664.1  regulator of chromosome condensation isoform c

      See identical proteins and their annotated locations for NP_001041664.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a. Both variants 3 and 4 encode the same isoform. This variant is a read-through transcript between the upstream non-coding SNHG3 locus (GeneID:8420) and the downstream RCC1 locus (GeneID:1104).
      Source sequence(s)
      BC007300, BU501614
      Consensus CDS
      CCDS323.1
      UniProtKB/Swiss-Prot
      P18754
      UniProtKB/TrEMBL
      Q5T081
      Related
      ENSP00000381931.2, ENST00000398958.6
      Conserved Domains (1) summary
      COG5184
      Location:4418
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    4. NM_001269.6NP_001260.1  regulator of chromosome condensation isoform c

      See identical proteins and their annotated locations for NP_001260.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a. Both variants 3 and 4 encode the same isoform.
      Source sequence(s)
      AL513497, BF590413, X12654
      Consensus CDS
      CCDS323.1
      UniProtKB/Swiss-Prot
      P18754
      UniProtKB/TrEMBL
      Q5T081
      Related
      ENSP00000362938.1, ENST00000373832.5
      Conserved Domains (1) summary
      COG5184
      Location:4418
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    5. NM_001381865.2NP_001368794.1  regulator of chromosome condensation isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5), as well as variants 3, 4, and 6, encodes isoform c.
      Source sequence(s)
      AL513497
      Related
      ENSP00000508074.1, ENST00000683442.1
      Conserved Domains (1) summary
      COG5184
      Location:4418
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    6. NM_001381866.2NP_001368795.1  regulator of chromosome condensation isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variants 3-5, encodes isoform c.
      Source sequence(s)
      AL513497
      Related
      ENSP00000362939.5, ENST00000373833.10
      Conserved Domains (1) summary
      COG5184
      Location:4418
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      28506043..28538989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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