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    Shroom2 shroom family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 110380, updated on 23-May-2018

    Summary

    Official Symbol
    Shroom2provided by MGI
    Official Full Name
    shroom family member 2provided by MGI
    Primary source
    MGI:MGI:107194
    See related
    Ensembl:ENSMUSG00000045180 Vega:OTTMUSG00000019337
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Apxl; Shrm2; 4832440C16; C630003H05Rik
    Expression
    Broad expression in CNS E18 (RPKM 10.6), frontal lobe adult (RPKM 7.9) and 22 other tissues See more
    Orthologs

    Genomic context

    See Shroom2 in Genome Data Viewer
    Location:
    X F3; X 68.46 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (152609509..152770256, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (149044052..149204004, complement)

    Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene claudin 34A Neighboring gene cell division protein kinase 4 pseudogene Neighboring gene RAB7, member RAS oncogene family pseudogene Neighboring gene phosphoglycerate mutase 2 pseudogene Neighboring gene G protein-coupled receptor 143 Neighboring gene ribosomal protein L7A, pseudogene 12 Neighboring gene ribosomal protein S7 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    beta-catenin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    NOT actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    apical protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    camera-type eye development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    camera-type eye morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT cell morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction maintenance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular pigment accumulation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    ear development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    establishment of melanosome localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    eye pigment granule organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    lens morphogenesis in camera-type eye ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    melanosome organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of actin filament depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    apical junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    apical junction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    bicellular tight junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell-cell adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290684.1NP_001277613.1  protein Shroom2 isoform 2

      See identical proteins and their annotated locations for NP_001277613.1

      Status: VALIDATED

      Source sequence(s)
      AL805960, AL807777
      Consensus CDS
      CCDS72455.1
      UniProtKB/Swiss-Prot
      A2ALU4
      Related
      ENSMUSP00000057500.4, OTTMUSP00000020862, ENSMUST00000062317.4, OTTMUST00000046170
      Conserved Domains (3) summary
      cd00992
      Location:24105
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam08687
      Location:11861474
      ASD2; Apx/Shroom domain ASD2
      pfam08688
      Location:662836
      ASD1; Apx/Shroom domain ASD1
    2. NM_001290685.1NP_001277614.1  protein Shroom2 isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AK049833, AK049850, AL805960, BC092373, BY125315
      UniProtKB/Swiss-Prot
      A2ALU4
      UniProtKB/TrEMBL
      Q8C7N5
      Conserved Domains (1) summary
      pfam08687
      Location:166454
      ASD2; Apx/Shroom domain ASD2
    3. NM_001290686.1NP_001277615.1  protein Shroom2 isoform 4

      See identical proteins and their annotated locations for NP_001277615.1

      Status: VALIDATED

      Source sequence(s)
      AK029338, AK049833, BY125315
      UniProtKB/Swiss-Prot
      A2ALU4
      UniProtKB/TrEMBL
      Q8C7N5
      Conserved Domains (1) summary
      pfam08687
      Location:151439
      ASD2; Apx/Shroom domain ASD2
    4. NM_001290687.2NP_001277616.1  protein Shroom2 isoform 4

      See identical proteins and their annotated locations for NP_001277616.1

      Status: VALIDATED

      Source sequence(s)
      AK049833, AK049850, AL805960, CF534250, CO431718
      UniProtKB/Swiss-Prot
      A2ALU4
      UniProtKB/TrEMBL
      Q8C7N5
      Conserved Domains (1) summary
      pfam08687
      Location:151439
      ASD2; Apx/Shroom domain ASD2
    5. NM_001359158.1NP_001346087.1  protein Shroom2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL805960
      Conserved Domains (1) summary
      pfam08687
      Location:151439
      ASD2; Apx/Shroom domain ASD2
    6. NM_001359161.1NP_001346090.1  protein Shroom2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL805960
      Conserved Domains (1) summary
      pfam08687
      Location:151439
      ASD2; Apx/Shroom domain ASD2
    7. NM_001359163.1NP_001346092.1  protein Shroom2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL805960
      Conserved Domains (1) summary
      pfam08687
      Location:151439
      ASD2; Apx/Shroom domain ASD2
    8. NM_172441.3NP_766029.2  protein Shroom2 isoform 1

      See identical proteins and their annotated locations for NP_766029.2

      Status: VALIDATED

      Source sequence(s)
      AK049833, AK049850, AL805960, AL807777, BF463332, CK635066
      Consensus CDS
      CCDS41179.1
      UniProtKB/Swiss-Prot
      A2ALU4
      UniProtKB/TrEMBL
      A7TU71, Q8C7N5
      Related
      ENSMUSP00000098701.2, ENSMUST00000101141.8
      Conserved Domains (3) summary
      cd00992
      Location:24105
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam08687
      Location:11921480
      ASD2; Apx/Shroom domain ASD2
      pfam08688
      Location:662836
      ASD1; Apx/Shroom domain ASD1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

      Range
      152609509..152770256 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528683.3XP_006528746.1  protein Shroom2 isoform X1

      Conserved Domains (3) summary
      cd00992
      Location:24105
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam08687
      Location:11871475
      ASD2; Apx/Shroom domain ASD2
      pfam08688
      Location:662836
      ASD1; Apx/Shroom domain ASD1
    2. XM_011247773.1XP_011246075.1  protein Shroom2 isoform X2

      UniProtKB/Swiss-Prot
      A2ALU4
      Conserved Domains (1) summary
      pfam08687
      Location:151439
      ASD2; Apx/Shroom domain ASD2
    3. XM_011247772.1XP_011246074.1  protein Shroom2 isoform X2

      UniProtKB/Swiss-Prot
      A2ALU4
      Conserved Domains (1) summary
      pfam08687
      Location:151439
      ASD2; Apx/Shroom domain ASD2
    4. XM_011247774.2XP_011246076.1  protein Shroom2 isoform X2

      See identical proteins and their annotated locations for XP_011246076.1

      UniProtKB/Swiss-Prot
      A2ALU4
      Conserved Domains (1) summary
      pfam08687
      Location:151439
      ASD2; Apx/Shroom domain ASD2
    5. XM_011247775.2XP_011246077.1  protein Shroom2 isoform X2

      See identical proteins and their annotated locations for XP_011246077.1

      UniProtKB/Swiss-Prot
      A2ALU4
      Conserved Domains (1) summary
      pfam08687
      Location:151439
      ASD2; Apx/Shroom domain ASD2
    6. XM_011247776.2XP_011246078.1  protein Shroom2 isoform X2

      UniProtKB/Swiss-Prot
      A2ALU4
      Conserved Domains (1) summary
      pfam08687
      Location:151439
      ASD2; Apx/Shroom domain ASD2
    7. XM_011247777.2XP_011246079.1  protein Shroom2 isoform X2

      See identical proteins and their annotated locations for XP_011246079.1

      UniProtKB/Swiss-Prot
      A2ALU4
      Conserved Domains (1) summary
      pfam08687
      Location:151439
      ASD2; Apx/Shroom domain ASD2
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