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    Bcr BCR activator of RhoGEF and GTPase [ Mus musculus (house mouse) ]

    Gene ID: 110279, updated on 15-Oct-2019

    Summary

    Official Symbol
    Bcrprovided by MGI
    Official Full Name
    BCR activator of RhoGEF and GTPaseprovided by MGI
    Primary source
    MGI:MGI:88141
    See related
    Ensembl:ENSMUSG00000009681
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI561783; AI853148; mKIAA3017; 5133400C09Rik
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 14.4), lung adult (RPKM 12.9) and 28 other tissues See more
    Orthologs

    Genomic context

    See Bcr in Genome Data Viewer
    Location:
    10 C1; 10 38.49 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    108 current GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75060560..75184923)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (74523641..74647668)

    Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene radial spoke head homolog 14 (Chlamydomonas) Neighboring gene predicted gene, 40692 Neighboring gene uncharacterized LOC115487404 Neighboring gene RAB36, member RAS oncogene family Neighboring gene sperm antigen with calponin homology and coiled-coil domains 1-like Neighboring gene ATP synthase subunit f, mitochondrial pseudogene Neighboring gene adenosine A2a receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activator activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    GTPase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Rho guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    brain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    definitive hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    homeostasis of number of cells IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inner ear morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    intracellular protein transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of cellular extravasation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neutrophil degranulation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of respiratory burst IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuromuscular process controlling balance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    platelet-derived growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of phagocytosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of nitrogen compound metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of vascular permeability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    renal system process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    small GTPase mediated signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    postsynaptic density, intracellular component ISO
    Inferred from Sequence Orthology
    more info
     
    postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    breakpoint cluster region protein
    Names
    breakpoint cluster region homolog
    NP_001074881.1
    XP_006513123.1
    XP_006513124.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081412.2NP_001074881.1  breakpoint cluster region protein

      See identical proteins and their annotated locations for NP_001074881.1

      Status: VALIDATED

      Source sequence(s)
      AC160402, BC131682
      Consensus CDS
      CCDS35935.1
      UniProtKB/Swiss-Prot
      Q6PAJ1
      UniProtKB/TrEMBL
      A2RRK7
      Related
      ENSMUSP00000126377.1, ENSMUST00000164107.2
      Conserved Domains (5) summary
      cd08686
      Location:9121032
      C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
      cd04387
      Location:10511251
      RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...
      pfam00621
      Location:501689
      RhoGEF; RhoGEF domain
      pfam09036
      Location:375
      Bcr-Abl_Oligo; Bcr-Abl oncoprotein oligomerization domain
      cl17171
      Location:683876
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p6 C57BL/6J

    Genomic

    1. NC_000076.6 Reference GRCm38.p6 C57BL/6J

      Range
      75060560..75184923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513060.4XP_006513123.1  breakpoint cluster region protein isoform X1

      Conserved Domains (4) summary
      pfam00621
      Location:501689
      RhoGEF; RhoGEF domain
      pfam09036
      Location:375
      Bcr-Abl_Oligo; Bcr-Abl oncoprotein oligomerization domain
      cl14603
      Location:9121003
      C2; C2 domain
      cl17171
      Location:683876
      PH-like; Pleckstrin homology-like domain
    2. XM_006513061.4XP_006513124.1  breakpoint cluster region protein isoform X2

      Conserved Domains (4) summary
      cd08686
      Location:452572
      C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
      cd04387
      Location:591791
      RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...
      pfam00621
      Location:41229
      RhoGEF; RhoGEF domain
      cl17171
      Location:223416
      PH-like; Pleckstrin homology-like domain
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