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    Tmbim6 transmembrane BAX inhibitor motif containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 110213, updated on 12-Sep-2021

    Summary

    Official Symbol
    Tmbim6provided by MGI
    Official Full Name
    transmembrane BAX inhibitor motif containing 6provided by MGI
    Primary source
    MGI:MGI:99682
    See related
    Ensembl:ENSMUSG00000023010
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bi1; Tegt; 5031406P05Rik
    Expression
    Ubiquitous expression in kidney adult (RPKM 555.8), liver adult (RPKM 490.6) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tmbim6 in Genome Data Viewer
    Location:
    15 F1; 15 56.13 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (99290828..99307930)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (99392947..99410049)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (99223378..99240480)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 186, member B Neighboring gene pre-mRNA processing factor 40B Neighboring gene formin-like 3 Neighboring gene predicted gene, 22951 Neighboring gene VISTA enhancer mm1635 Neighboring gene NCK-associated protein 5-like Neighboring gene NCK-associated protein 5-like, opposite strand

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endoribonuclease inhibitor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables endoribonuclease inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within autophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to unfolded protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to unfolded protein ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within endoplasmic reticulum calcium ion homeostasis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of RNA splicing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of calcium ion transport into cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endoribonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of endoribonuclease activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of immunoglobulin production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to L-glutamate ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    bax inhibitor 1
    Names
    BI-1
    testis enhanced gene transcript
    testis-enhanced gene transcript protein
    transmembrane BAX inhibitor motif-containing protein 6

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001171034.1NP_001164505.1  bax inhibitor 1

      See identical proteins and their annotated locations for NP_001164505.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 4 encode the same protein.
      Source sequence(s)
      AK036782, AK139901, BE990530, BY272301, CD554385
      Consensus CDS
      CCDS37201.1
      UniProtKB/Swiss-Prot
      Q9D2C7
      Related
      ENSMUSP00000125563.2, ENSMUST00000161250.8
      Conserved Domains (1) summary
      cd10430
      Location:16228
      BI-1; BAX inhibitor (BI)-1
    2. NM_001171035.1NP_001164506.1  bax inhibitor 1

      See identical proteins and their annotated locations for NP_001164506.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same protein.
      Source sequence(s)
      AK036782, AK139901, BE990530, BY158276, BY753376
      Consensus CDS
      CCDS37201.1
      UniProtKB/Swiss-Prot
      Q9D2C7
      Related
      ENSMUSP00000125117.2, ENSMUST00000159209.8
      Conserved Domains (1) summary
      cd10430
      Location:16228
      BI-1; BAX inhibitor (BI)-1
    3. NM_001171036.1NP_001164507.1  bax inhibitor 1

      See identical proteins and their annotated locations for NP_001164507.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same protein.
      Source sequence(s)
      AC118646, AK036782, AK139901, BE990530, BY272301
      Consensus CDS
      CCDS37201.1
      UniProtKB/Swiss-Prot
      Q9D2C7
      Related
      ENSMUSP00000124651.2, ENSMUST00000160635.8
      Conserved Domains (1) summary
      cd10430
      Location:16228
      BI-1; BAX inhibitor (BI)-1
    4. NM_026669.4NP_080945.1  bax inhibitor 1

      See identical proteins and their annotated locations for NP_080945.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 4 encode the same protein.
      Source sequence(s)
      AK036782, AK139901, BE990530, BY272301
      Consensus CDS
      CCDS37201.1
      UniProtKB/Swiss-Prot
      Q9D2C7
      Related
      ENSMUSP00000023749.9, ENSMUST00000023749.15
      Conserved Domains (1) summary
      cd10430
      Location:16228
      BI-1; BAX inhibitor (BI)-1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      99290828..99307930
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159068.1XP_036014961.1  bax inhibitor 1 isoform X1

      Conserved Domains (1) summary
      cd10430
      Location:16228
      BI-1; BAX inhibitor (BI)-1
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