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    Pgd phosphogluconate dehydrogenase [ Mus musculus (house mouse) ]

    Gene ID: 110208, updated on 6-Jul-2021

    Summary

    Official Symbol
    Pgdprovided by MGI
    Official Full Name
    phosphogluconate dehydrogenaseprovided by MGI
    Primary source
    MGI:MGI:97553
    See related
    Ensembl:ENSMUSG00000028961
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C78335; AU019875; 0610042A05Rik
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 156.7), mammary gland adult (RPKM 135.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Pgd in Genome Data Viewer
    Location:
    4 E2; 4 78.96 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (149234448..149251162, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (149149991..149166705, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (148524094..148540816, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein SA, pseudogene 12 Neighboring gene centromere protein S Neighboring gene kinesin family member 1B Neighboring gene ubiquitination factor E4B, opposite strand 3 Neighboring gene ubiquitination factor E4B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NADP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables NADP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables carbohydrate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables carboxylic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphogluconate 2-dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphogluconate dehydrogenase (decarboxylating) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables phosphogluconate dehydrogenase (decarboxylating) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phosphogluconate dehydrogenase (decarboxylating) activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in D-gluconate catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in D-gluconate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in NADP metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in carbohydrate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within pentose biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in pentose-phosphate shunt ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in pentose-phosphate shunt, oxidative branch IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in pentose-phosphate shunt, oxidative branch ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    6-phosphogluconate dehydrogenase, decarboxylating
    NP_001074743.1
    NP_001343261.1
    XP_006538535.1
    XP_030108942.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081274.2NP_001074743.1  6-phosphogluconate dehydrogenase, decarboxylating isoform 1

      See identical proteins and their annotated locations for NP_001074743.1

      Status: VALIDATED

      Source sequence(s)
      AI834806, AK145602, CX212251, CX215938
      Consensus CDS
      CCDS38974.1
      UniProtKB/Swiss-Prot
      Q9DCD0
      Related
      ENSMUSP00000081141.7, ENSMUST00000084124.7
      Conserved Domains (3) summary
      PRK09287
      Location:14470
      PRK09287; 6-phosphogluconate dehydrogenase; Validated
      pfam00393
      Location:180469
      6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain
      pfam03446
      Location:3176
      NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase
    2. NM_001356332.1NP_001343261.1  6-phosphogluconate dehydrogenase, decarboxylating isoform 2

      Status: VALIDATED

      Source sequence(s)
      AI834806, AK145602, AL731655, CX212251
      Conserved Domains (1) summary
      pfam00393
      Location:1285
      6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      149234448..149251162 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253082.2XP_030108942.1  6-phosphogluconate dehydrogenase, decarboxylating isoform X1

      Conserved Domains (1) summary
      pfam00393
      Location:1285
      6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain
    2. XM_006538472.4XP_006538535.1  6-phosphogluconate dehydrogenase, decarboxylating isoform X1

      Conserved Domains (1) summary
      pfam00393
      Location:1285
      6PGD; 6-phosphogluconate dehydrogenase, C-terminal domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_025801.1: Suppressed sequence

      Description
      NM_025801.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
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