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    Raf1 v-raf-leukemia viral oncogene 1 [ Mus musculus (house mouse) ]

    Gene ID: 110157, updated on 5-Sep-2021

    Summary

    Official Symbol
    Raf1provided by MGI
    Official Full Name
    v-raf-leukemia viral oncogene 1provided by MGI
    Primary source
    MGI:MGI:97847
    See related
    Ensembl:ENSMUSG00000000441
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    v-; Cra; Raf; c-R; cRaf; Craf1; Raf-1; c-Raf; v-Raf; AA990557; BB129353; 6430402F14Rik; D830050J10Rik
    Expression
    Ubiquitous expression in CNS E14 (RPKM 50.6), whole brain E14.5 (RPKM 48.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Raf1 in Genome Data Viewer
    Location:
    6 E3; 6 53.62 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (115595530..115653596, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (115618569..115676635, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (115568591..115626653, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36355 Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene makorin, ring finger protein 2, opposite strand Neighboring gene makorin, ring finger protein, 2 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor pseudogene Neighboring gene RIKEN cDNA D830050J10 gene Neighboring gene predicted gene, 38879 Neighboring gene predicted gene, 24008

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102375

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables MAP kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables MAP kinase kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables adenylate cyclase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables adenylate cyclase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mitogen-activated protein kinase kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in activation of adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within cellular glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within death-inducing signaling complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within face development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intermediate filament cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intracellular signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neurotrophin TRK receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to muscle stretch IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within somatic stem cell population maintenance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within thymus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within thyroid gland development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in pseudopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    RAF proto-oncogene serine/threonine-protein kinase
    Names
    Craf1 transforming
    murine sarcoma 3611 oncogene 1
    proto-oncogene c-RAF
    NP_001343262.1
    NP_001343263.1
    NP_084056.1
    XP_006505427.1
    XP_030110958.1
    XP_030110959.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356333.2NP_001343262.1  RAF proto-oncogene serine/threonine-protein kinase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC160032
      Conserved Domains (3) summary
      cd14149
      Location:356638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      pfam00130
      Location:139184
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    2. NM_001356334.2NP_001343263.1  RAF proto-oncogene serine/threonine-protein kinase isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC160032
      Consensus CDS
      CCDS20441.1
      Related
      ENSMUSP00000108571.2, ENSMUST00000112949.8
      Conserved Domains (3) summary
      cd01816
      Location:57131
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14149
      Location:336618
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00130
      Location:139187
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    3. NM_029780.4NP_084056.1  RAF proto-oncogene serine/threonine-protein kinase isoform 1

      See identical proteins and their annotated locations for NP_084056.1

      Status: VALIDATED

      Source sequence(s)
      AK141745, BF455519
      Consensus CDS
      CCDS20441.1
      UniProtKB/Swiss-Prot
      Q99N57
      Related
      ENSMUSP00000000451.8, ENSMUST00000000451.14
      Conserved Domains (3) summary
      cd01816
      Location:57131
      Raf_RBD; Ubiquitin domain of Raf serine/threonine kinases
      cd14149
      Location:336618
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00130
      Location:139187
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      115595530..115653596 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006505364.3XP_006505427.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      See identical proteins and their annotated locations for XP_006505427.1

      UniProtKB/Swiss-Prot
      Q99N57
      Conserved Domains (3) summary
      cd14149
      Location:356638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      pfam00130
      Location:139184
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    2. XM_030255099.1XP_030110959.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

      Conserved Domains (3) summary
      cd14149
      Location:255537
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00130
      Location:58103
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      cl28922
      Location:2750
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    3. XM_030255098.1XP_030110958.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

      Conserved Domains (2) summary
      cd14149
      Location:275557
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      pfam00130
      Location:58103
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
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