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    Dnah12 dynein, axonemal, heavy chain 12 [ Mus musculus (house mouse) ]

    Gene ID: 110083, updated on 8-Dec-2018

    Summary

    Official Symbol
    Dnah12provided by MGI
    Official Full Name
    dynein, axonemal, heavy chain 12provided by MGI
    Primary source
    MGI:MGI:107720
    See related
    Ensembl:ENSMUSG00000021879
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DHC3; Gm74; HL19; DLP12; Gm284; Gm907; HL-19; Hdhc3; Dnahc3; Dnah12l; Dnahc12; Dnahc7c; Dnahc7l; 4921531P07Rik
    Expression
    Biased expression in testis adult (RPKM 2.7) and lung adult (RPKM 0.5) See more
    Orthologs

    Genomic context

    See Dnah12 in Genome Data Viewer
    Location:
    14 A3; 14 16.09 cM
    Exon count:
    77
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (26691548..26892284)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (27512760..27558864)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor 4 Neighboring gene microRNA 7672 Neighboring gene phosphodiesterase 12 Neighboring gene predicted gene, 34415 Neighboring gene ankyrin repeat and SOCS box-containing 14 Neighboring gene host cell factor C1 regulator 1 pseudogene Neighboring gene adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Pathways from BioSystems

    • Huntington's disease, organism-specific biosystem (from KEGG)
      Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
    • Huntington's disease, conserved biosystem (from KEGG)
      Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...

    General gene information

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent microtubule motor activity, minus-end-directed IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dynein light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    cilium IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    inner dynein arm ISM
    Inferred from Sequence Model
    more info
    PubMed 
    microtubule IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dynein heavy chain 12, axonemal
    Names
    axonemal beta dynein heavy chain 12
    axonemal dynein heavy chain 12-like protein
    axonemal dynein heavy chain 7-like protein
    ciliary dynein heavy chain 12
    dynein, axonemal, heavy chain 3

    NCBI Reference Sequences (RefSeq)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      26691548..26892284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316242.1XP_017171731.1  dynein heavy chain 12, axonemal isoform X2

    2. XM_017316243.1XP_017171732.1  dynein heavy chain 12, axonemal isoform X3

      Related
      ENSMUSP00000022433.5, ENSMUST00000022433.11
    3. XM_017316241.1XP_017171730.1  dynein heavy chain 12, axonemal isoform X1

    RNA

    1. XR_001781207.1 RNA Sequence

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