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    Dut deoxyuridine triphosphatase [ Mus musculus (house mouse) ]

    Gene ID: 110074, updated on 22-Aug-2021

    Summary

    Official Symbol
    Dutprovided by MGI
    Official Full Name
    deoxyuridine triphosphataseprovided by MGI
    Primary source
    MGI:MGI:1346051
    See related
    Ensembl:ENSMUSG00000027203
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dutp; dUTPase; D2Bwg0749e; 5031412I06Rik; 5133400F09Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 32.2), liver E14 (RPKM 31.2) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Dut in Genome Data Viewer
    Location:
    2 F1; 2 61.33 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (125089168..125100969)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (125247248..125259049)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (125072984..125084785)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 12, member 1 Neighboring gene predicted gene, 46760 Neighboring gene predicted gene 14002 Neighboring gene fibrillin 1 Neighboring gene centrosomal protein 152 Neighboring gene 60S ribosomal protein L27 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dUTP diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables dUTP diphosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables peroxisome proliferator activated receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables pyrimidine deoxyribonucleotide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables signaling receptor inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in dTMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in dUMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in dUMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in dUTP catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in dUTP catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
    NP_001153118.1
    NP_076084.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159646.1NP_001153118.1  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_001153118.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK135438, AK153285
      Consensus CDS
      CCDS50695.1
      UniProtKB/TrEMBL
      Q8VCG1, Q9CQ43
      Related
      ENSMUSP00000080767.8, ENSMUST00000082122.14
      Conserved Domains (1) summary
      cl00493
      Location:61198
      trimeric_dUTPase; Trimeric dUTP diphosphatases
    2. NM_023595.6NP_076084.2  deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_076084.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK077244, AK153285
      Consensus CDS
      CCDS16675.1
      UniProtKB/TrEMBL
      Q9CQ43
      Related
      ENSMUSP00000057854.9, ENSMUST00000051605.9
      Conserved Domains (1) summary
      cl00493
      Location:23160
      trimeric_dUTPase; Trimeric dUTP diphosphatases

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      125089168..125100969
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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