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    KIF2C kinesin family member 2C [ Homo sapiens (human) ]

    Gene ID: 11004, updated on 21-Dec-2019

    Summary

    Official Symbol
    KIF2Cprovided by HGNC
    Official Full Name
    kinesin family member 2Cprovided by HGNC
    Primary source
    HGNC:HGNC:6393
    See related
    Ensembl:ENSG00000142945 MIM:604538
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCAK; CT139; KNSL6
    Summary
    This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
    Expression
    Biased expression in testis (RPKM 39.1), bone marrow (RPKM 9.5) and 6 other tissues See more
    Orthologs

    Genomic context

    See KIF2C in Genome Data Viewer
    Location:
    1p34.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (44739704..44767767)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (45205396..45233439)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene armadillo like helical domain containing 1 Neighboring gene uncharacterized LOC105378690 Neighboring gene RNA, U5F small nuclear 1 Neighboring gene RNA, U5D small nuclear 1 Neighboring gene small nucleolar RNA, C/D box 160 Neighboring gene small nucleolar RNA, C/D box 55 Neighboring gene small nucleolar RNA, C/D box 46 Neighboring gene ribosomal protein S8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The DNA repair gene DNA-PKcs and cell cycle-related genes Cdc20, Cdc25C, KIF2C and CTS1 are downregulated in HIV-1 Tat-expressing human rhabdomyosarcoma cells PubMed
    Vpr vpr HIV-1 Vpr upregulates KIF2C in HeLa cells within 12 hours of exposure PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    centromeric DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule plus-end binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    cell IEA
    Inferred from Electronic Annotation
    more info
     
    centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chromosome, centromeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    condensed chromosome kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with cytoplasmic microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane HDA PubMed 
    microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    microtubule plus-end IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule plus-end TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    kinesin-like protein KIF2C
    Names
    kinesin-like protein 6
    mitotic centromere-associated kinesin
    testis tissue sperm-binding protein Li 68n

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001297655.2NP_001284584.1  kinesin-like protein KIF2C isoform 2

      See identical proteins and their annotated locations for NP_001284584.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB264115, AK300756, BU615368
      UniProtKB/Swiss-Prot
      Q99661
      UniProtKB/TrEMBL
      B7Z6Q6
      Conserved Domains (2) summary
      cd01367
      Location:217545
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      pfam00225
      Location:223546
      Kinesin; Kinesin motor domain
    2. NM_001297656.2NP_001284585.1  kinesin-like protein KIF2C isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as tsMCAK) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK302267, AY026505, BC014924, BU615368, DC404550
      Consensus CDS
      CCDS72774.1
      UniProtKB/Swiss-Prot
      Q99661
      UniProtKB/TrEMBL
      B7Z7M6
      Related
      ENSP00000361291.1, ENST00000372217.5
      Conserved Domains (2) summary
      cd01367
      Location:204532
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      pfam00225
      Location:210533
      Kinesin; Kinesin motor domain
    3. NM_001297657.2NP_001284586.1  kinesin-like protein KIF2C isoform 4

      See identical proteins and their annotated locations for NP_001284586.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK302267, BC014924, BU615368, DC399082
      UniProtKB/Swiss-Prot
      Q99661
      UniProtKB/TrEMBL
      B7Z7M6
      Conserved Domains (2) summary
      cd01367
      Location:145473
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      pfam00225
      Location:151474
      Kinesin; Kinesin motor domain
    4. NM_006845.4NP_006836.2  kinesin-like protein KIF2C isoform 1

      See identical proteins and their annotated locations for NP_006836.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AU130795, BC008764, BC014924, BU615368
      Consensus CDS
      CCDS512.1
      UniProtKB/Swiss-Prot
      Q99661
      UniProtKB/TrEMBL
      A0A140VKF1
      Related
      ENSP00000361298.4, ENST00000372224.9
      Conserved Domains (1) summary
      cd01367
      Location:258586
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

      Range
      44739704..44767767
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011540540.2XP_011538842.1  kinesin-like protein KIF2C isoform X1

      See identical proteins and their annotated locations for XP_011538842.1

      UniProtKB/TrEMBL
      B7Z7M6
      Conserved Domains (2) summary
      cd01367
      Location:145473
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      pfam00225
      Location:151474
      Kinesin; Kinesin motor domain
    2. XM_011540541.2XP_011538843.1  kinesin-like protein KIF2C isoform X1

      See identical proteins and their annotated locations for XP_011538843.1

      UniProtKB/TrEMBL
      B7Z7M6
      Conserved Domains (2) summary
      cd01367
      Location:145473
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      pfam00225
      Location:151474
      Kinesin; Kinesin motor domain
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