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    Abr active BCR-related gene [ Mus musculus (house mouse) ]

    Gene ID: 109934, updated on 5-Sep-2021

    Summary

    Official Symbol
    Abrprovided by MGI
    Official Full Name
    active BCR-related geneprovided by MGI
    Primary source
    MGI:MGI:107771
    See related
    Ensembl:ENSMUSG00000017631
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Broad expression in frontal lobe adult (RPKM 53.0), cortex adult (RPKM 47.8) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Abr in Genome Data Viewer
    Location:
    11 B5; 11 45.92 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (76307558..76468565, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (76416732..76623324, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (76230236..76391229, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene nucleoredoxin Neighboring gene translocase of inner mitochondrial membrane 22 Neighboring gene predicted gene 12341 Neighboring gene predicted gene, 53687 Neighboring gene ribosomal protein L36, pseudogene 2 Neighboring gene breakpoint cluster region pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • 6330400K15Rik

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activator activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in activation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within brain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within inner ear morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in modulation of chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of blood vessel remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of cellular extravasation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of neutrophil degranulation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neuromuscular process controlling balance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of phagocytosis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of vascular permeability IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within response to lipopolysaccharide IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    active breakpoint cluster region-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291186.1NP_001278115.1  active breakpoint cluster region-related protein isoform 4

      See identical proteins and their annotated locations for NP_001278115.1

      Status: VALIDATED

      Source sequence(s)
      BC056385, BY629085, CB246381
      Consensus CDS
      CCDS70246.1
      UniProtKB/Swiss-Prot
      Q5SSL4
      Related
      ENSMUSP00000068982.8, ENSMUST00000065028.14
      Conserved Domains (4) summary
      cd08686
      Location:288408
      C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
      cd04387
      Location:427622
      RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...
      cd13366
      Location:59242
      PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
      cl02571
      Location:1765
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    2. NM_001346670.1NP_001333599.1  active breakpoint cluster region-related protein isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL591143, AL663050
      Consensus CDS
      CCDS83843.1
      UniProtKB/Swiss-Prot
      Q5SSL4
      Related
      ENSMUSP00000104045.3, ENSMUST00000108408.9
    3. NM_001363379.1NP_001350308.1  active breakpoint cluster region-related protein isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL663050
      Conserved Domains (2) summary
      cd04387
      Location:102297
      RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
      cl14603
      Location:5583
      C2; C2 domain
    4. NM_198018.2NP_932135.1  active breakpoint cluster region-related protein isoform 1

      See identical proteins and their annotated locations for NP_932135.1

      Status: VALIDATED

      Source sequence(s)
      BC058708, BY629085
      Consensus CDS
      CCDS36231.1
      UniProtKB/Swiss-Prot
      Q5SSL4
      Related
      ENSMUSP00000091551.5, ENSMUST00000094012.11
      Conserved Domains (4) summary
      cd08686
      Location:518638
      C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
      cd00160
      Location:104294
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd04387
      Location:657852
      RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...
      cd13366
      Location:289472
      PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
    5. NM_198894.2NP_942597.1  active breakpoint cluster region-related protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      BC058708, BY126026, BY629085, CF535448
      Consensus CDS
      CCDS25067.1
      UniProtKB/Swiss-Prot
      Q5SSL4
      UniProtKB/TrEMBL
      E9PUE7
      Conserved Domains (4) summary
      cd08686
      Location:460580
      C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
      cd04387
      Location:599794
      RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...
      cd13366
      Location:231414
      PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
      pfam00621
      Location:49237
      RhoGEF; RhoGEF domain
    6. NM_198895.2NP_942598.1  active breakpoint cluster region-related protein isoform 3

      See identical proteins and their annotated locations for NP_942598.1

      Status: VALIDATED

      Source sequence(s)
      AK142364, BC058708, BY629085, CJ147649
      Consensus CDS
      CCDS25066.1
      UniProtKB/Swiss-Prot
      Q5SSL4
      Related
      ENSMUSP00000072522.7, ENSMUST00000072740.13
      Conserved Domains (4) summary
      cd08686
      Location:506626
      C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
      cd04387
      Location:645840
      RhoGAP_Bcr; RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, ...
      cd13366
      Location:277460
      PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
      pfam00621
      Location:95283
      RhoGEF; RhoGEF domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      76307558..76468565 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245469.1XP_030101329.1  active breakpoint cluster region-related protein isoform X1

      Conserved Domains (4) summary
      cd08686
      Location:473593
      C2_ABR; C2 domain in the Active BCR (Breakpoint cluster region) Related protein
      cd00160
      Location:84249
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd04387
      Location:612807
      RhoGAP_Bcr; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr ...
      cd13366
      Location:244427
      PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
    2. XM_036156228.1XP_036012121.1  active breakpoint cluster region-related protein isoform X2

      Conserved Domains (3) summary
      cd00160
      Location:92282
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13366
      Location:277460
      PH_ABR; Active breakpoint cluster region-related protein pleckstrin homology (PH) domain
      cl14603
      Location:506597
      C2; C2 domain
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