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    RNA45SN3 RNA, 45S pre-ribosomal N3 [ Homo sapiens (human) ]

    Gene ID: 109910379, updated on 8-Feb-2025

    Summary

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    Official Symbol
    RNA45SN3provided by HGNC
    Official Full Name
    RNA, 45S pre-ribosomal N3provided by HGNC
    Primary source
    HGNC:HGNC:53522
    See related
    AllianceGenome:HGNC:53522
    Gene type
    rRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    45S ribosomal DNA (rDNA) arrays, or clusters, are present on human chromosomes 13, 14, 15, 21 and 22, designated RNR1 through RNR5, respectively. Each cluster consists of multiple 45S rDNA repeat units that vary in number among individuals and chromosomes, with total diploid copy number estimates ranging from 60 to >800 repeat units in a human genome. The 45S rDNA repeat unit encodes a 45S rRNA precursor, transcribed by RNA polymerase I, which is processed to form the 18S, 5.8S and 28S rRNAs. This gene represents a copy of the 45S ribosomal RNA on chromosome 21. [provided by RefSeq, Mar 2017]
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    Genomic context

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    See RNA45SN3 in Genome Data Viewer
    Location:
    21p11.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (8389035..8402343)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (3873497..3886844)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene RNA, 28S ribosomal pseudogene Neighboring gene microRNA 6724-3 Neighboring gene RNA, 18S ribosomal N3 Neighboring gene RNA, 5.8S ribosomal N3 Neighboring gene RNA, 28S ribosomal N3 Neighboring gene cell division cycle 27 pseudogene 10 Neighboring gene microRNA 6724-4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleolar organizer regions: genomic 'dark matter' requiring illumination. McStay B. Genes Dev, 2016 Jul 15. PMID 27474438, Free PMC Article
    2. The human 18S ribosomal RNA gene: evolution and stability. Gonzalez IL, et al. Am J Hum Genet, 1986 Apr. PMID 2422931, Free PMC Article
    3. A novel strategy for constructing clustered point mutations. Haltiner M, et al. Nucleic Acids Res, 1985 Feb 11. PMID 2987803, Free PMC Article
    4. Evolutionary changes of sequences and factors that direct transcription termination of human and mouse ribsomal genes. Bartsch I, et al. Mol Cell Biol, 1987 Jul. PMID 3649563, Free PMC Article
    5. Primary processing of mammalian rRNA involves two adjacent cleavages and is not species specific. Kass S, et al. Mol Cell Biol, 1987 Aug. PMID 3670298, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    General gene information

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    Other Names

    • RNA, 45S ribosomal

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in miRNA-mediated post-transcriptional gene silencing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_146151.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      FP236383

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      8389035..8402343
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_021160023.1 Reference GRCh38.p14 PATCHES

      Range
      436160..449468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      3873497..3886844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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