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    Cpa1 carboxypeptidase A1, pancreatic [ Mus musculus (house mouse) ]

    Gene ID: 109697, updated on 19-Feb-2019

    Summary

    Official Symbol
    Cpa1provided by MGI
    Official Full Name
    carboxypeptidase A1, pancreaticprovided by MGI
    Primary source
    MGI:MGI:88478
    See related
    Ensembl:ENSMUSG00000054446
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cpa; 0910001L12Rik
    Summary
    This gene encodes carboxypeptidase A, a zinc-dependent metalloprotease that cleaves peptide bonds at the C-terminus of protein substrates. The encoded preproprotein undergoes proteolytic activation to generate a mature, functional enzyme. This gene is expressed in pancreas, the encoded protein is a major component of digestive enzymes secreted by pancreas and plays an important role in the process of digestion. This gene is located in a cluster of related carboxypeptidase genes on chromosome 6. [provided by RefSeq, Jan 2016]
    Expression
    Biased expression in small intestine adult (RPKM 1152.1), spleen adult (RPKM 853.6) and 2 other tissues See more
    Orthologs

    Genomic context

    See Cpa1 in Genome Data Viewer
    Location:
    6 A3.3; 6 12.52 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (30639218..30645361)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (30589221..30595361)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 31453 Neighboring gene carboxypeptidase A5 Neighboring gene centrosomal protein 41 Neighboring gene predicted gene 13782 Neighboring gene mesoderm specific transcript Neighboring gene microRNA 335

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Pancreatic secretion, organism-specific biosystem (from KEGG)
      Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Pancreatic secretion, conserved biosystem (from KEGG)
      Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Protein digestion and absorption, organism-specific biosystem (from KEGG)
      Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
    • Protein digestion and absorption, conserved biosystem (from KEGG)
      Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    exopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    carboxypeptidase A1
    NP_079626.2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025350.4NP_079626.2  carboxypeptidase A1 preproprotein

      See identical proteins and their annotated locations for NP_079626.2

      Status: REVIEWED

      Source sequence(s)
      AC155656, BC052661
      Consensus CDS
      CCDS19977.1
      UniProtKB/Swiss-Prot
      Q7TPZ8
      Related
      ENSMUSP00000031806.9, ENSMUST00000031806.9
      Conserved Domains (2) summary
      cd03870
      Location:117417
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:2799
      Propep_M14; Carboxypeptidase activation peptide

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      30639218..30645361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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