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    TCERG1 transcription elongation regulator 1 [ Homo sapiens (human) ]

    Gene ID: 10915, updated on 27-Nov-2024

    Summary

    Official Symbol
    TCERG1provided by HGNC
    Official Full Name
    transcription elongation regulator 1provided by HGNC
    Primary source
    HGNC:HGNC:15630
    See related
    Ensembl:ENSG00000113649 MIM:605409; AllianceGenome:HGNC:15630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Urn1; CA150; TAF2S
    Summary
    This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 13.4), bone marrow (RPKM 13.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TCERG1 in Genome Data Viewer
    Location:
    5q32
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (146447330..146511961)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (146983202..147047833)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (145826893..145891524)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RBM27-POU4F3 Neighboring gene MPRA-validated peak5522 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:145724002-145724515 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:145725029-145725541 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_81810 Neighboring gene uncharacterized LOC105378213 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_81818 Neighboring gene Sharpr-MPRA regulatory region 15640 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_81828 Neighboring gene POU class 4 homeobox 3 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:145826559-145827266 Neighboring gene MPRA-validated peak5524 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:145920194-145920694 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:145939738-145940393 Neighboring gene G protein-coupled receptor 151 Neighboring gene uncharacterized CTB-99A3.1 Neighboring gene RNA, 5S ribosomal pseudogene 196 Neighboring gene protein phosphatase 2 regulatory subunit Bbeta

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Both CA150 and HIV-1 Tat associate with the RNA polymerase II holoenzyme and are required for Tat transactivation of the HIV-1 LTR promoter PubMed
    tat HIV-1 Tat-mediated splicing is dependent on splicing associated factors Tat-SF1 and CA150 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC133200

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in nuclear speck TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    transcription elongation regulator 1
    Names
    TATA box binding protein (TBP)-associated factor, RNA polymerase II, S, 150kD
    TATA box-binding protein-associated factor 2S
    co-activator of 150 kDa
    transcription factor CA150

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040006.2NP_001035095.1  transcription elongation regulator 1 isoform 2

      See identical proteins and their annotated locations for NP_001035095.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame coding exons compared to variant 3, resulting in a shorter protein (isoform 2) compared to isoform 3.
      Source sequence(s)
      AB209910, AC011375, AF017789, DA034307, DA737038
      Consensus CDS
      CCDS43379.1
      UniProtKB/TrEMBL
      G3V220
      Related
      ENSP00000377943.2, ENST00000394421.7
      Conserved Domains (4) summary
      COG5104
      Location:400997
      PRP40; Splicing factor [RNA processing and modification]
      pfam00397
      Location:137162
      WW; WW domain
      pfam01846
      Location:9941053
      FF; FF domain
      pfam03154
      Location:258395
      Atrophin-1; Atrophin-1 family
    2. NM_001382548.1NP_001369477.1  transcription elongation regulator 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes the longest isoform (3).
      Source sequence(s)
      AC011375
      Consensus CDS
      CCDS93799.1
      UniProtKB/TrEMBL
      A0A7P0T8N8, G3V220
      Related
      ENSP00000505217.1, ENST00000679501.2
      Conserved Domains (5) summary
      smart00456
      Location:132164
      WW; Domain with 2 conserved Trp (W) residues
      COG5104
      Location:4211035
      PRP40; Splicing factor [RNA processing and modification]
      pfam05109
      Location:260365
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam01846
      Location:10321091
      FF; FF domain
      cl28929
      Location:323413
      VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)
    3. NM_001400077.1NP_001387006.1  transcription elongation regulator 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC011375
    4. NM_001400082.1NP_001387011.1  transcription elongation regulator 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011375
    5. NM_001400083.1NP_001387012.1  transcription elongation regulator 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC011375
    6. NM_001400084.1NP_001387013.1  transcription elongation regulator 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC011375
    7. NM_001400085.1NP_001387014.1  transcription elongation regulator 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC011375
    8. NM_001400092.1NP_001387021.1  transcription elongation regulator 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC011375
    9. NM_001400093.1NP_001387022.1  transcription elongation regulator 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC011375
    10. NM_001400094.1NP_001387023.1  transcription elongation regulator 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC011375
    11. NM_001400095.1NP_001387024.1  transcription elongation regulator 1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC011375
    12. NM_001400096.1NP_001387025.1  transcription elongation regulator 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC011375
    13. NM_001400097.1NP_001387026.1  transcription elongation regulator 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC011375
    14. NM_001400098.1NP_001387027.1  transcription elongation regulator 1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC011375
    15. NM_001400099.1NP_001387028.1  transcription elongation regulator 1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC011375
    16. NM_006706.4NP_006697.2  transcription elongation regulator 1 isoform 1

      See identical proteins and their annotated locations for NP_006697.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame coding exon compared to variant 3, resulting in a shorter protein (isoform 1) compared to isoform 3.
      Source sequence(s)
      AC011375, AF017789, BC111727, DA034307, DA737038
      Consensus CDS
      CCDS4282.1
      UniProtKB/Swiss-Prot
      O14776, Q2NKN2, Q59EA1
      UniProtKB/TrEMBL
      G3V220
      Related
      ENSP00000296702.5, ENST00000296702.9
      Conserved Domains (5) summary
      COG5104
      Location:4211018
      PRP40; Splicing factor [RNA processing and modification]
      pfam05109
      Location:260365
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam00397
      Location:137162
      WW; WW domain
      pfam01846
      Location:10151074
      FF; FF domain
      cl28929
      Location:323413
      VirB10_like; VirB10 and similar proteins form part of core complex in Type IV secretion system (T4SS)

    RNA

    1. NR_174389.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    2. NR_174390.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    3. NR_174391.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    4. NR_174406.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    5. NR_174407.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    6. NR_174408.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    7. NR_174409.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    8. NR_174410.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    9. NR_174411.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    10. NR_174412.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    11. NR_174413.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    12. NR_174414.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    13. NR_174415.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    14. NR_174416.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    15. NR_174417.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    16. NR_174418.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    17. NR_174419.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    18. NR_174420.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    19. NR_174421.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    20. NR_174422.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    21. NR_174423.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    22. NR_174424.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    23. NR_174425.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    24. NR_174426.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    25. NR_174427.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    26. NR_174428.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    27. NR_174429.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    28. NR_174430.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    29. NR_174431.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    30. NR_174432.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    31. NR_174433.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    32. NR_174434.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    33. NR_174435.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    34. NR_174436.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    35. NR_174437.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    36. NR_174438.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
      Related
      ENST00000707167.1
    37. NR_174439.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    38. NR_174440.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    39. NR_174441.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    40. NR_174442.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    41. NR_174443.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    42. NR_174444.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    43. NR_174445.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    44. NR_174446.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    45. NR_174447.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    46. NR_174448.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    47. NR_174449.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    48. NR_174450.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    49. NR_174451.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    50. NR_174452.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    51. NR_174453.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375
    52. NR_174454.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC011375

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      146447330..146511961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008978.3XP_016864467.1  transcription elongation regulator 1 isoform X1

      UniProtKB/TrEMBL
      G3V220
    2. XM_017008979.3XP_016864468.1  transcription elongation regulator 1 isoform X2

      UniProtKB/TrEMBL
      G3V220
    3. XM_047416659.1XP_047272615.1  transcription elongation regulator 1 isoform X3

    4. XM_017008980.2XP_016864469.1  transcription elongation regulator 1 isoform X4

      UniProtKB/TrEMBL
      G3V220
    5. XM_047416660.1XP_047272616.1  transcription elongation regulator 1 isoform X7

    6. XM_017008984.2XP_016864473.1  transcription elongation regulator 1 isoform X5

      UniProtKB/TrEMBL
      B7Z921
    7. XM_017008985.2XP_016864474.1  transcription elongation regulator 1 isoform X6

      UniProtKB/TrEMBL
      B7Z921

    RNA

    1. XR_001741983.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      146983202..147047833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351491.1XP_054207466.1  transcription elongation regulator 1 isoform X1

    2. XM_054351492.1XP_054207467.1  transcription elongation regulator 1 isoform X2

    3. XM_054351493.1XP_054207468.1  transcription elongation regulator 1 isoform X3

    4. XM_054351494.1XP_054207469.1  transcription elongation regulator 1 isoform X4

    5. XM_054351497.1XP_054207472.1  transcription elongation regulator 1 isoform X7

    6. XM_054351495.1XP_054207470.1  transcription elongation regulator 1 isoform X5

    7. XM_054351496.1XP_054207471.1  transcription elongation regulator 1 isoform X6

    RNA

    1. XR_008487075.1 RNA Sequence