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    Pfdn4 prefoldin 4 [ Mus musculus (house mouse) ]

    Gene ID: 109054, updated on 23-Jun-2021

    Summary

    Official Symbol
    Pfdn4provided by MGI
    Official Full Name
    prefoldin 4provided by MGI
    Primary source
    MGI:MGI:1923512
    See related
    Ensembl:ENSMUSG00000052033
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C1; C-1; PFD; Pfd4; 0610025M10Rik; 1810063B06Rik
    Expression
    Biased expression in placenta adult (RPKM 16.3), CNS E18 (RPKM 14.7) and 14 other tissues See more
    Orthologs
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    Genomic context

    See Pfdn4 in Genome Data Viewer
    Location:
    2 H3; 2 91.91 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (170338348..170360990)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (170496428..170519070)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (170321928..170344567)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 34608 Neighboring gene predicted gene, 40000 Neighboring gene cytochrome P450, family 24, subfamily a, polypeptide 1 Neighboring gene predicted gene, 16796 Neighboring gene predicted gene, 40001 Neighboring gene RIKEN cDNA 4930470P17 gene Neighboring gene predicted gene 14637

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of amyloid fibril formation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of prefoldin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of prefoldin complex ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013369.2NP_001013387.1  prefoldin subunit 4 isoform 2

      See identical proteins and their annotated locations for NP_001013387.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 2. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      BC065407, BU503885
      Consensus CDS
      CCDS50808.1
      UniProtKB/TrEMBL
      Q6P0X1
      Related
      ENSMUSP00000074596.2, ENSMUST00000075087.8
      Conserved Domains (1) summary
      pfam01920
      Location:167
      Prefoldin_2; Prefoldin subunit
    2. NM_001110152.2NP_001103622.1  prefoldin subunit 4 isoform 1

      See identical proteins and their annotated locations for NP_001103622.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK136249, BU503885
      Consensus CDS
      CCDS50807.1
      UniProtKB/TrEMBL
      Q3UWL8
      Related
      ENSMUSP00000070596.6, ENSMUST00000063682.12
      Conserved Domains (1) summary
      pfam01920
      Location:23125
      Prefoldin_2; Prefoldin subunit
    3. NM_001199902.1NP_001186831.1  prefoldin subunit 4 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
      Source sequence(s)
      AK136249, BC048510, BU503885
      Consensus CDS
      CCDS57190.1
      UniProtKB/TrEMBL
      E9Q6U4, Q3UWL8
      Related
      ENSMUSP00000130383.2, ENSMUST00000136839.2
      Conserved Domains (1) summary
      pfam01920
      Location:20120
      Prefoldin_2; Prefoldin subunit

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      170338348..170360990
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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