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    Tpr translocated promoter region, nuclear basket protein [ Mus musculus (house mouse) ]

    Gene ID: 108989, updated on 23-Jun-2021

    Summary

    Official Symbol
    Tprprovided by MGI
    Official Full Name
    translocated promoter region, nuclear basket proteinprovided by MGI
    Primary source
    MGI:MGI:1922066
    See related
    Ensembl:ENSMUSG00000006005
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C77892; 2610029M07Rik
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 19.4), placenta adult (RPKM 13.2) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Tpr in Genome Data Viewer
    Location:
    1; 1 G1
    Exon count:
    52
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (150268544..150325686)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (150392802..150449935)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (152239968..152297065)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protein BEX4-like Neighboring gene RIKEN cDNA 2310030A07 gene Neighboring gene phosducin Neighboring gene odr4 GPCR localization factor homolog Neighboring gene proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) Neighboring gene predicted gene, 41967 Neighboring gene spindle and kinetochore associated complex subunit 2-like, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables structural constituent of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in RNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in RNA import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to heat ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to interferon-alpha IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mRNA export from nucleus in response to heat stress ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic spindle assembly checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of RNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of heterochromatin assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of intracellular protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mitotic sister chromatid separation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to epidermal growth factor ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytoplasmic dynein complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extrinsic component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear inclusion body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear periphery ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
     
    part_of nuclear pore nuclear basket ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nucleoprotein TPR
    Names
    NPC-associated intranuclear protein
    nuclear pore complex-associated protein Tpr
    translocated promoter region and nuclear basket protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133780.3NP_598541.3  nucleoprotein TPR

      See identical proteins and their annotated locations for NP_598541.3

      Status: VALIDATED

      Source sequence(s)
      AC161432
      Consensus CDS
      CCDS35734.2
      UniProtKB/Swiss-Prot
      F6ZDS4
      Related
      ENSMUSP00000117616.3, ENSMUST00000124973.9
      Conserved Domains (6) summary
      pfam05483
      Location:3631147
      SCP-1; Synaptonemal complex protein 1 (SCP-1)
      TIGR04527
      Location:10391124
      mycoplas_twoTM; two transmembrane protein
      pfam07926
      Location:11121240
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      cl12013
      Location:300446
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
      cl19219
      Location:430575
      DUF342; Protein of unknown function (DUF342)
      cl23720
      Location:902984
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      150268544..150325686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529065.4XP_006529128.1  nucleoprotein TPR isoform X1

      Conserved Domains (5) summary
      COG1196
      Location:127870
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR00927
      Location:18972135
      2A1904; K+-dependent Na+/Ca+ exchanger
      TIGR02168
      Location:8471687
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05109
      Location:17021936
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam07926
      Location:11101238
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
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