Nusap1 nucleolar and spindle associated protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nusap1provided by MGI
Official Full Name: nucleolar and spindle associated protein 1provided by MGI
Primary source: MGI:MGI:2675669
See related: Ensembl:ENSMUSG00000027306 AllianceGenome:MGI:2675669
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LNP; ANKT; SAPL; BM037; NuSAP; Q0310; 2610201A12Rik
Summary: Enables microtubule binding activity. Predicted to be involved in establishment of mitotic spindle localization; mitotic chromosome condensation; and mitotic cytokinesis. Predicted to act upstream of or within mitotic sister chromatid segregation and positive regulation of mitotic nuclear division. Located in nucleolus. Is expressed in genitourinary system. Orthologous to human NUSAP1 (nucleolar and spindle associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E14 (RPKM 34.2), liver E14.5 (RPKM 28.2) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2; 2 E5

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (119448779..119480646)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (119618298..119650165)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this work has uncovered an ATM-dependent checkpoint pathway that prevents mitotic progression by targeting a microtubule-associated protein, NuSAP.
Title: ATM-mediated NuSAP phosphorylation induces mitotic arrest.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI481307 (e-PCR)
- UniSTS:178688

NoName (e-PCR)
- UniSTS:237850

AW547774 (e-PCR)
- UniSTS:185488

BB165529 (e-PCR)
- UniSTS:185489

Homology

Homologs of the Nusap1 gene: The Nusap1 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 452 organisms have orthologs with human gene Nusap1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in establishment of mitotic spindle localization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within establishment of mitotic spindle localization	ISO Inferred from Sequence Orthology more info	PubMed
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in mitotic chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within mitotic chromosome condensation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within mitotic cytokinesis	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within mitotic sister chromatid segregation	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: nucleolar and spindle-associated protein 1

Names: nucleolar protein ANKT

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042652.2 → NP_001036117.1 nucleolar and spindle-associated protein 1 isoform b

See identical proteins and their annotated locations for NP_001036117.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.

Source sequence(s)

AL844536

Consensus CDS

CCDS38206.1

UniProtKB/Swiss-Prot

Q9ERH4

Related

ENSMUSP00000028771.8, ENSMUST00000028771.8

Conserved Domains (1) summary

pfam16006
Location:161 → 388

NUSAP; Nucleolar and spindle-associated protein
NM_133851.4 → NP_598612.1 nucleolar and spindle-associated protein 1 isoform a

See identical proteins and their annotated locations for NP_598612.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).

Source sequence(s)

AL844536

Consensus CDS

CCDS16605.1

UniProtKB/Swiss-Prot

Q921Z0, Q9ERH4

Related

ENSMUSP00000068713.9, ENSMUST00000068225.15

Conserved Domains (1) summary

pfam16006
Location:170 → 421

NUSAP; Nucleolar and spindle-associated protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

119448779..119480646

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246564.2 → XP_030102424.1 nucleolar and spindle-associated protein 1 isoform X1

Conserved Domains (1) summary

pfam16006
Location:40 → 269

NUSAP; Nucleolar and spindle-associated protein