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    Nusap1 nucleolar and spindle associated protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 108907, updated on 9-Sep-2018

    Summary

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    Official Symbol
    Nusap1provided by MGI
    Official Full Name
    nucleolar and spindle associated protein 1provided by MGI
    Primary source
    MGI:MGI:2675669
    See related
    Ensembl:ENSMUSG00000027306 Vega:OTTMUSG00000015954
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    LNP; ANKT; SAPL; BM037; NuSAP; Q0310; AI481307; AW547774; BB165529; 2610201A12Rik
    Expression
    Biased expression in liver E14 (RPKM 34.2), liver E14.5 (RPKM 28.2) and 10 other tissues See more
    Orthologs
    human all

    Genomic context

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    See Nusap1 in Genome Data Viewer
    Location:
    2; 2 E5
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (119618298..119650165)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (119444034..119475896)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene calcineurin-like EF hand protein 1 Neighboring gene RIKEN cDNA 1700020I14 gene Neighboring gene Opa interacting protein 5 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 1 Neighboring gene H3 histone, family 3C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SAP-like domain in nucleolar spindle associated protein mediates mitotic chromosome loading as well as interphase chromatin interaction. Verbakel W, et al. Biochem Biophys Res Commun, 2011 Aug 12. PMID 21782797
    2. ATM-mediated NuSAP phosphorylation induces mitotic arrest. Xie P, et al. Biochem Biophys Res Commun, 2011 Jan 7. PMID 21130744
    3. A role for NuSAP in linking microtubules to mitotic chromosomes. Ribbeck K, et al. Curr Biol, 2007 Feb 6. PMID 17276916
    4. NuSAP, a novel microtubule-associated protein involved in mitotic spindle organization. Raemaekers T, et al. J Cell Biol, 2003 Sep 15. PMID 12963707, Free PMC Article
    5. NuSAP is essential for chromatin-induced spindle formation during early embryogenesis. Vanden Bosch A, et al. J Cell Sci, 2010 Oct 1. PMID 20807801

    See all (30) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    1. this work has uncovered an ATM-dependent checkpoint pathway that prevents mitotic progression by targeting a microtubule-associated protein, NuSAP.
      Title: ATM-mediated NuSAP phosphorylation induces mitotic arrest.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		 PubMed 
    microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    establishment of mitotic spindle localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		 PubMed 
    establishment of mitotic spindle localization ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic chromosome condensation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		 PubMed 
    mitotic chromosome condensation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    mitotic cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		 PubMed 
    mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    mitotic sister chromatid segregation ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    positive regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		 PubMed 
    nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		 PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		 PubMed 
    colocalizes_with spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleolar and spindle-associated protein 1
    Names
    nucleolar protein ANKT

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042652.1 → NP_001036117.1  nucleolar and spindle-associated protein 1 isoform b

      See identical proteins and their annotated locations for NP_001036117.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a.
      Source sequence(s)
      AK042697, AK044819, CD544519
      Consensus CDS
      CCDS38206.1
      UniProtKB/Swiss-Prot
      Q9ERH4
      Related
      ENSMUSP00000028771.7, OTTMUSP00000017021, ENSMUST00000028771.7, OTTMUST00000037918
      Conserved Domains (1) summary
      pfam16006
      Location:161 → 388
      NUSAP; Nucleolar and spindle-associated protein

    2. NM_133851.3 → NP_598612.1  nucleolar and spindle-associated protein 1 isoform a

      See identical proteins and their annotated locations for NP_598612.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).
      Source sequence(s)
      AK044819, BC100392
      Consensus CDS
      CCDS16605.1
      UniProtKB/Swiss-Prot
      Q9ERH4
      Related
      ENSMUSP00000068713.8, OTTMUSP00000017020, ENSMUST00000068225.14, OTTMUST00000037917
      Conserved Domains (1) summary
      pfam16006
      Location:170 → 421
      NUSAP; Nucleolar and spindle-associated protein

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      119618298..119650165
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011239246.2 → XP_011237548.1  nucleolar and spindle-associated protein 1 isoform X1

      Conserved Domains (1) summary
      pfam16006
      Location:40 → 291
      NUSAP; Nucleolar and spindle-associated protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ERH4.1 GenPept UniProtKB/Swiss-Prot:Q9ERH4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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