U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    PROKR1 prokineticin receptor 1 [ Homo sapiens (human) ]

    Gene ID: 10887, updated on 11-Apr-2024

    Summary

    Official Symbol
    PROKR1provided by HGNC
    Official Full Name
    prokineticin receptor 1provided by HGNC
    Primary source
    HGNC:HGNC:4524
    See related
    Ensembl:ENSG00000169618 MIM:607122; AllianceGenome:HGNC:4524
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZAQ; PKR1; GPR73; PK-R1; GPR73a
    Summary
    This gene encodes a member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded protein is expressed in peripheral tissues such as those comprising the circulatory system, lungs, reproductive system, endocrine system and the gastrointestinal system. The protein may be involved in signaling in human fetal ovary during initiation of primordial follicle formation. Sequence variants in this gene may be associated with recurrent miscarriage. [provided by RefSeq, Aug 2016]
    Expression
    Biased expression in fat (RPKM 1.4), adrenal (RPKM 0.7) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    2p13.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (68643579..68658251)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (68655911..68670584)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (68870711..68885383)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene aprataxin and PNKP like factor Neighboring gene putative UPF0607 protein ENSP00000383783 pseudogene Neighboring gene transmembrane and coiled-coil domain family 1 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:68906264-68906888 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:68906889-68907513 Neighboring gene Sharpr-MPRA regulatory region 5025 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15958 Neighboring gene Rho GTPase activating protein 25 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15959 Neighboring gene NANOG hESC enhancer GRCh37_chr2:68971645-68972146 Neighboring gene uncharacterized LOC105374790 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15960 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15961 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15962 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15963 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15964 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:69042669-69043169 Neighboring gene CRISPRi-validated cis-regulatory element chr2.2482 Neighboring gene long intergenic non-protein coding RNA 1890 Neighboring gene long intergenic non-protein coding RNA 1888

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: APLF

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables neuropeptide Y receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in circadian rhythm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuropeptide signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    prokineticin receptor 1
    Names
    G protein-coupled receptor 73
    G protein-coupled receptor ZAQ

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051312.1 RefSeqGene

      Range
      5001..16989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_138964.4NP_620414.1  prokineticin receptor 1

      See identical proteins and their annotated locations for NP_620414.1

      Status: REVIEWED

      Source sequence(s)
      AC105054
      Consensus CDS
      CCDS1889.1
      UniProtKB/Swiss-Prot
      A5JUU2, Q53QT9, Q8NFJ7, Q8TCW9
      UniProtKB/TrEMBL
      A0A7I2V3D2
      Related
      ENSP00000303775.4, ENST00000303786.5
      Conserved Domains (1) summary
      cd15204
      Location:63353
      7tmA_prokineticin-R; prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      68643579..68658251
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      68655911..68670584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)