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    NPFFR2 neuropeptide FF receptor 2 [ Homo sapiens (human) ]

    Gene ID: 10886, updated on 10-Oct-2024

    Summary

    Official Symbol
    NPFFR2provided by HGNC
    Official Full Name
    neuropeptide FF receptor 2provided by HGNC
    Primary source
    HGNC:HGNC:4525
    See related
    Ensembl:ENSG00000056291 MIM:607449; AllianceGenome:HGNC:4525
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GPR74; NPFF2; NPGPR; HLWAR77
    Summary
    This gene encodes a member of a subfamily of G-protein-coupled neuropeptide receptors. This protein is activated by the neuropeptides A-18-amide (NPAF) and F-8-amide (NPFF) and may function in pain modulation and regulation of the opioid system. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2009]
    Expression
    Biased expression in placenta (RPKM 1.4), thyroid (RPKM 0.2) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See NPFFR2 in Genome Data Viewer
    Location:
    4q13.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (72032000..72148305)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (75374029..75490284)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (72897717..73014022)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:72479894-72481093 Neighboring gene uncharacterized LOC105377271 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:72519382-72520581 Neighboring gene RNA, 5S ribosomal pseudogene 163 Neighboring gene VISTA enhancer hs2570 Neighboring gene GC vitamin D binding protein Neighboring gene ReSE screen-validated silencer GRCh37_chr4:72836369-72836534 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:72897326-72897928 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:72960191-72960690 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:72977919-72979118 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:73019056-73019842 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 3 Neighboring gene Sharpr-MPRA regulatory region 5509 Neighboring gene NANOG hESC enhancer GRCh37_chr4:73529485-73530023 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 67

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables neuropeptide receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables opioid receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to hormone stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in detection of abiotic stimulus TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in neuropeptide signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of adenylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cAMP-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    neuropeptide FF receptor 2
    Names
    G-protein coupled receptor 74
    G-protein coupled receptor HLWAR77
    neuropeptide FF 2
    neuropeptide G-protein coupled receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001144756.2NP_001138228.1  neuropeptide FF receptor 2 isoform 3

      See identical proteins and their annotated locations for NP_001138228.1

      Status: REVIEWED

      Source sequence(s)
      AC106051, AC106898, AF119815, AF236083, AK290937, CN285250
      Consensus CDS
      CCDS47072.1
      UniProtKB/Swiss-Prot
      Q96RV1, Q9NR49, Q9Y5X5
      Related
      ENSP00000379321.1, ENST00000395999.5
      Conserved Domains (2) summary
      pfam00001
      Location:65336
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:56178
      7tm_4; Olfactory receptor
    2. NM_004885.3NP_004876.3  neuropeptide FF receptor 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC106051, AC106898
      Consensus CDS
      CCDS3552.1
      UniProtKB/Swiss-Prot
      Q96RV1, Q9NR49, Q9Y5X5
      UniProtKB/TrEMBL
      A0PJM9
      Related
      ENSP00000307822.7, ENST00000308744.12
      Conserved Domains (1) summary
      cd15980
      Location:46344
      7tmA_NPFFR2; neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
    3. NM_053036.3NP_444264.1  neuropeptide FF receptor 2 isoform 1

      See identical proteins and their annotated locations for NP_444264.1

      Status: REVIEWED

      Source sequence(s)
      AC106051, AC106898, AF119815, AK290937, CN285250
      Consensus CDS
      CCDS3552.1
      UniProtKB/Swiss-Prot
      Q96RV1, Q9NR49, Q9Y5X5
      UniProtKB/TrEMBL
      A0PJM9
      Related
      ENSP00000351599.3, ENST00000358749.3
      Conserved Domains (1) summary
      cd15980
      Location:46344
      7tmA_NPFFR2; neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      72032000..72148305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531554.3XP_011529856.2  neuropeptide FF receptor 2 isoform X1

    2. XM_047449545.1XP_047305501.1  neuropeptide FF receptor 2 isoform X2

      Related
      ENST00000506359.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      75374029..75490284
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054348802.1XP_054204777.1  neuropeptide FF receptor 2 isoform X1

    2. XM_054348803.1XP_054204778.1  neuropeptide FF receptor 2 isoform X2