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    Ibtk inhibitor of Bruton agammaglobulinemia tyrosine kinase [ Mus musculus (house mouse) ]

    Gene ID: 108837, updated on 8-Aug-2021

    Summary

    Official Symbol
    Ibtkprovided by MGI
    Official Full Name
    inhibitor of Bruton agammaglobulinemia tyrosine kinaseprovided by MGI
    Primary source
    MGI:MGI:1918677
    See related
    Ensembl:ENSMUSG00000035941
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BTKI; AA409502; mKIAA1417; 5430411K16Rik
    Expression
    Ubiquitous expression in bladder adult (RPKM 7.6), CNS E11.5 (RPKM 6.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ibtk in Genome Data Viewer
    Location:
    9; 9 E3.1
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (85569412..85632756, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (85687359..85750703, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (85580963..85637766, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene terminal nucleotidyltransferase 5A Neighboring gene predicted gene, 25125 Neighboring gene predicted gene, 22830 Neighboring gene ribosomal protein L7A pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein tyrosine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    inhibitor of Bruton tyrosine kinase

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081282.2NP_001074751.1  inhibitor of Bruton tyrosine kinase isoform 1

      See identical proteins and their annotated locations for NP_001074751.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AK031796, BB639555, BC137798, BP760552
      Consensus CDS
      CCDS40712.1
      UniProtKB/Swiss-Prot
      Q6ZPR6
      Related
      ENSMUSP00000041145.9, ENSMUST00000039213.15
      Conserved Domains (8) summary
      smart00225
      Location:770872
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd00204
      Location:47135
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cd14821
      Location:872919
      SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
      pfam00415
      Location:247299
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam00651
      Location:562643
      BTB; BTB/POZ domain
      pfam12796
      Location:25116
      Ank_2; Ankyrin repeats (3 copies)
      pfam13540
      Location:232260
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat
      sd00045
      Location:5182
      ANK; ANK repeat [structural motif]
    2. NM_175371.3NP_780580.2  inhibitor of Bruton tyrosine kinase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and uses an in-frame downstream translation start site, compared to variant 1. It encodes a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC155934
      Conserved Domains (2) summary
      cd14821
      Location:312359
      SPOP_C_like; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
      pfam00651
      Location:280
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      85569412..85632756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510765.4XP_006510828.1  inhibitor of Bruton tyrosine kinase isoform X1

      Conserved Domains (7) summary
      COG5184
      Location:139341
      ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      sd00045
      Location:5182
      ANK; ANK repeat [structural motif]
      cd18301
      Location:546651
      BTB1_POZ_IBtk; first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
      cd18302
      Location:763875
      BTB2_POZ_IBtk; second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
      cd18500
      Location:871930
      BACK_IBtk; BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk)
      pfam00415
      Location:247299
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam12796
      Location:45116
      Ank_2; Ankyrin repeats (3 copies)
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