Send to:

Choose Destination
    • Showing Current items.

    CD300C CD300c molecule [ Homo sapiens (human) ]

    Gene ID: 10871, updated on 8-Oct-2019


    Official Symbol
    CD300Cprovided by HGNC
    Official Full Name
    CD300c moleculeprovided by HGNC
    Primary source
    See related
    Ensembl:ENSG00000167850 MIM:606786
    Gene type
    protein coding
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LIR; CLM-6; CMRF35; IGSF16; CMRF-35; CMRF35A; CMRF-35A; CMRF35A1; CMRF35-A1
    The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]).[supplied by OMIM, Mar 2008]
    Broad expression in lung (RPKM 2.9), appendix (RPKM 2.6) and 19 other tissues See more

    Genomic context

    See CD300C in Genome Data Viewer
    Exon count:
    Annotation release Status Assembly Chr Location
    109.20190905 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (74534359..74546115, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72537204..72542310, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene CD300a molecule Neighboring gene CD300 molecule like family member b Neighboring gene uncharacterized LOC107985074 Neighboring gene CD300H molecule (gene/pseudogene) Neighboring gene CD300 molecule like family member d Neighboring gene chromosome 17 open reading frame 77

    Genomic regions, transcripts, and products


    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018


    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
      Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...


    Products Interactant Other Gene Complex Source Pubs Description

    General gene information



    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    transmembrane signaling receptor activity TAS
    Traceable Author Statement
    more info
    Process Evidence Code Pubs
    cellular defense response TAS
    Traceable Author Statement
    more info
    immune system process IEA
    Inferred from Electronic Annotation
    more info
    regulation of immune response TAS
    Traceable Author Statement
    more info
    Component Evidence Code Pubs
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    plasma membrane TAS
    Traceable Author Statement
    more info

    General protein information

    Preferred Names
    CMRF35-like molecule 6
    CD300 antigen-like family member C
    CD300c antigen
    CMRF35 antigen
    CMRF35 leukocyte immunoglobulin-like receptor
    CMRF35A leukocyte immunoglobulin-like receptor
    immunoglobulin superfamily member 16

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006678.5NP_006669.1  CMRF35-like molecule 6 precursor

      See identical proteins and their annotated locations for NP_006669.1

      Status: VALIDATED

      Source sequence(s)
      AC079325, BC022279, BF508242
      Consensus CDS
      ENSP00000329507.1, ENST00000330793.2
      Conserved Domains (2) summary
      Ig_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar domains
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly


    1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

      74534359..74546115 complement
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017024033.2XP_016879522.1  CMRF35-like molecule 6 isoform X1

    2. XM_017024034.2XP_016879523.1  CMRF35-like molecule 6 isoform X2

    Support Center