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    Gpt2 glutamic pyruvate transaminase (alanine aminotransferase) 2 [ Mus musculus (house mouse) ]

    Gene ID: 108682, updated on 23-Jun-2021

    Summary

    Official Symbol
    Gpt2provided by MGI
    Official Full Name
    glutamic pyruvate transaminase (alanine aminotransferase) 2provided by MGI
    Primary source
    MGI:MGI:1915391
    See related
    Ensembl:ENSMUSG00000031700
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AL; ALT2; C87201; AU014768; AU041193; 4631422C05Rik
    Expression
    Broad expression in liver adult (RPKM 35.8), subcutaneous fat pad adult (RPKM 28.6) and 23 other tissues See more
    Orthologs
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    Genomic context

    See Gpt2 in Genome Data Viewer
    Location:
    8; 8 C3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (86219090..86255531)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (85492576..85528902)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (88016516..88051457)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4921524J17 gene Neighboring gene predicted gene, 53446 Neighboring gene DnaJ heat shock protein family (Hsp40) member A2 Neighboring gene predicted gene, 51583

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-alanine:2-oxoglutarate aminotransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transaminase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in 2-oxoglutarate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in L-alanine metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    alanine aminotransferase 2
    Names
    glutamate pyruvate transaminase 2
    glutamic--alanine transaminase 2
    glutamic--pyruvic transaminase 2
    NP_776291.1
    XP_006530622.1
    XP_036009604.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173866.4NP_776291.1  alanine aminotransferase 2

      See identical proteins and their annotated locations for NP_776291.1

      Status: VALIDATED

      Source sequence(s)
      AC130533
      Consensus CDS
      CCDS22499.1
      UniProtKB/Swiss-Prot
      Q8BGT5
      Related
      ENSMUSP00000034136.6, ENSMUST00000034136.12
      Conserved Domains (2) summary
      cd00609
      Location:123512
      AAT_like; Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine ...
      PTZ00377
      Location:48522
      PTZ00377; alanine aminotransferase; Provisional

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      86219090..86255531
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153711.1XP_036009604.1  alanine aminotransferase 2 isoform X1

      Conserved Domains (1) summary
      PTZ00377
      Location:5379
      PTZ00377; alanine aminotransferase; Provisional
    2. XM_006530559.4XP_006530622.1  alanine aminotransferase 2 isoform X2

      Conserved Domains (1) summary
      PTZ00377
      Location:39290
      PTZ00377; alanine aminotransferase; Provisional

    RNA

    1. XR_004934746.1 RNA Sequence

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