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    Mat2b methionine adenosyltransferase II, beta [ Mus musculus (house mouse) ]

    Gene ID: 108645, updated on 23-Jun-2021

    Summary

    Official Symbol
    Mat2bprovided by MGI
    Official Full Name
    methionine adenosyltransferase II, betaprovided by MGI
    Primary source
    MGI:MGI:1913667
    See related
    Ensembl:ENSMUSG00000042032
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TGR; MATII; MAT-II; AI182287; AU022853; MATIIbeta; 1110064C04Rik; 2410018D16Rik
    Expression
    Ubiquitous expression in cortex adult (RPKM 34.1), bladder adult (RPKM 28.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Mat2b in Genome Data Viewer
    Location:
    11; 11 A5
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (40570141..40586030, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (40679314..40695203, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (40492816..40506115, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene Neighboring gene aldo-keto reductase family 1, member B3 pseudogene Neighboring gene hyaluronan mediated motility receptor (RHAMM) Neighboring gene NudC domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables methionine adenosyltransferase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables methionine adenosyltransferase regulator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in S-adenosylmethionine biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of methionine adenosyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of methionine adenosyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    methionine adenosyltransferase 2 subunit beta
    Names
    MAT II beta
    methionine adenosyltransferase 2 beta subunit
    NP_001186203.1
    NP_598778.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199274.1NP_001186203.1  methionine adenosyltransferase 2 subunit beta isoform 2

      See identical proteins and their annotated locations for NP_001186203.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate first exon which includes different sequence for the 5' coding region, compared to variant 1. The resulting protein (isoform 2) has a distinct and shorter N-terminus when it is compared to isoform 1.
      Source sequence(s)
      AK075947, BC003457, CA559663
      Consensus CDS
      CCDS56767.1
      UniProtKB/Swiss-Prot
      Q99LB6
      Related
      ENSMUSP00000098901.4, ENSMUST00000101347.10
      Conserved Domains (2) summary
      cd05254
      Location:19305
      dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs
      pfam04321
      Location:20311
      RmlD_sub_bind; RmlD substrate binding domain
    2. NM_134017.2NP_598778.1  methionine adenosyltransferase 2 subunit beta isoform 1

      See identical proteins and their annotated locations for NP_598778.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform a).
      Source sequence(s)
      AL646055, BC003457
      Consensus CDS
      CCDS24547.1
      UniProtKB/Swiss-Prot
      Q99LB6
      Related
      ENSMUSP00000048222.5, ENSMUST00000040167.11
      Conserved Domains (2) summary
      cd05254
      Location:30316
      dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs
      pfam04321
      Location:31322
      RmlD_sub_bind; RmlD substrate binding domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      40570141..40586030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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