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    CPLX1 complexin 1 [ Homo sapiens (human) ]

    Gene ID: 10815, updated on 8-Jul-2021

    Summary

    Official Symbol
    CPLX1provided by HGNC
    Official Full Name
    complexin 1provided by HGNC
    Primary source
    HGNC:HGNC:2309
    See related
    Ensembl:ENSG00000168993 MIM:605032
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CPX1; CPX-I; DEE63; EIEE63
    Summary
    Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 19.8), fat (RPKM 3.8) and 5 other tissues See more
    Orthologs
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    Genomic context

    See CPLX1 in Genome Data Viewer
    Location:
    4p16.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (784957..826129, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (778745..819917, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene polycomb group ring finger 3 Neighboring gene uncharacterized LOC107986246 Neighboring gene uncharacterized LOC100129917 Neighboring gene uncharacterized LOC105374339 Neighboring gene uncharacterized LOC105374340 Neighboring gene uncharacterized LOC105374341 Neighboring gene cyclin G associated kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SNARE binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables neurotransmitter transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables syntaxin-1 binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in calyx of Held IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
     
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex TAS
    Traceable Author Statement
    more info
    PubMed 
    is_active_in terminal bouton IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    complexin-1
    Names
    CPX I
    complexin I
    synaphin 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006651.4NP_006642.1  complexin-1

      See identical proteins and their annotated locations for NP_006642.1

      Status: REVIEWED

      Source sequence(s)
      AC139887
      Consensus CDS
      CCDS46995.1
      UniProtKB/Swiss-Prot
      O14810
      Related
      ENSP00000305613.6, ENST00000304062.11
      Conserved Domains (1) summary
      pfam05835
      Location:1133
      Synaphin; Synaphin protein

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

      Range
      784957..826129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011513391.1XP_011511693.1  complexin-1 isoform X1

      Related
      ENSP00000421947.1, ENST00000504062.1
      Conserved Domains (1) summary
      pfam05835
      Location:1118
      Synaphin; Synaphin protein
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