Format

Send to:

Choose Destination
    • Showing Current items.

    Napa N-ethylmaleimide sensitive fusion protein attachment protein alpha [ Mus musculus (house mouse) ]

    Gene ID: 108124, updated on 31-Jan-2019

    Summary

    Official Symbol
    Napaprovided by MGI
    Official Full Name
    N-ethylmaleimide sensitive fusion protein attachment protein alphaprovided by MGI
    Primary source
    MGI:MGI:104563
    See related
    Ensembl:ENSMUSG00000006024
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    hyh; RA81; SNAPA; SNARE; a-SNAP; AW209189; SNAP-alpha; 1500039N14Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 63.0), cerebellum adult (RPKM 61.5) and 28 other tissues See more
    Orthologs

    Genomic context

    See Napa in Genome Data Viewer
    Location:
    7 A2; 7 8.74 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (16098456..16117975)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (16683992..16703324)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene BRD4 interacting chromatin remodeling complex associated protein Neighboring gene predicted gene, 32059 Neighboring gene zinc finger protein 541 Neighboring gene kaptin Neighboring gene solute carrier family 8 (sodium/calcium exchanger), member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    SNARE binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    soluble NSF attachment protein activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    syntaxin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    syntaxin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    syntaxin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    SNARE complex disassembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    SNARE complex disassembly IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    apical protein localization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    protein-containing complex disassembly ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of synaptic vesicle priming IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of synaptic vesicle priming IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of synaptic vesicle priming IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synaptic transmission, glutamatergic IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    synaptic vesicle priming IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptic vesicle priming IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    SNARE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath HDA PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    presynapse ISO
    Inferred from Sequence Orthology
    more info
     
    synaptobrevin 2-SNAP-25-syntaxin-1a complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    synaptobrevin 2-SNAP-25-syntaxin-1a complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    synaptobrevin 2-SNAP-25-syntaxin-1a complex ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    vacuolar membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    alpha-soluble NSF attachment protein
    Names
    N-ethylmaleimide-sensitive factor attachment protein alpha
    hydrocephaly with hop gait

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025898.4NP_080174.1  alpha-soluble NSF attachment protein

      See identical proteins and their annotated locations for NP_080174.1

      Status: VALIDATED

      Source sequence(s)
      AK050623, AK078019, BY631159
      Consensus CDS
      CCDS20843.1
      UniProtKB/Swiss-Prot
      Q9DB05
      Related
      ENSMUSP00000006181.6, ENSMUST00000006181.6
      Conserved Domains (1) summary
      cd15832
      Location:26287
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      16098456..16117975
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539460.2XP_006539523.1  alpha-soluble NSF attachment protein isoform X1

      Conserved Domains (3) summary
      sd00006
      Location:114151
      TPR; TPR repeat [structural motif]
      cd15832
      Location:26188
      SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
      cl23717
      Location:176219
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    RNA

    1. XR_001785464.1 RNA Sequence

    Support Center