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    STARD10 StAR related lipid transfer domain containing 10 [ Homo sapiens (human) ]

    Gene ID: 10809, updated on 17-Jun-2024

    Summary

    Official Symbol
    STARD10provided by HGNC
    Official Full Name
    StAR related lipid transfer domain containing 10provided by HGNC
    Primary source
    HGNC:HGNC:10666
    See related
    Ensembl:ENSG00000214530 MIM:617382; AllianceGenome:HGNC:10666
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCTP2; CGI-52; NY-CO-28; SDCCAG28
    Summary
    Predicted to enable lipid binding activity. Predicted to be involved in lipid transport. Predicted to act upstream of or within bile acid secretion and positive regulation of peroxisome proliferator activated receptor signaling pathway. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver (RPKM 47.9), stomach (RPKM 44.9) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See STARD10 in Genome Data Viewer
    Location:
    11q13.4
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (72754729..72794047, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (72682966..72722274, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (72465774..72505092, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3724 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:72415096-72415932 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:72417010-72417596 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:72420686-72421388 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72423687-72424267 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72424849-72425428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72428169-72428669 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72428974-72429474 Neighboring gene ARAP1 antisense RNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5194 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3725 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5195 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5196 Neighboring gene ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 Neighboring gene ribosomal protein S12 pseudogene 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:72452199-72452976 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:72453754-72454530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5202 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3726 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72485809-72486308 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3727 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72493384-72494086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72497138-72498136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72498137-72499133 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72503217-72503716 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5206 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:72509227-72509964 Neighboring gene uncharacterized LOC107984421 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3730 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3731 Neighboring gene microRNA 4692 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5209 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5210 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:72537383-72537883 Neighboring gene autophagy related 16 like 2 Neighboring gene FCH and double SH3 domains 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: ARAP1

    Clone Names

    • MGC14401

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in intercellular canaliculus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in motile cilium IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    START domain-containing protein 10
    Names
    PCTP-L
    PCTP-like protein
    START domain containing 10
    StAR-related lipid transfer (START) domain containing 10
    antigen NY-CO-28
    serologically defined colon cancer antigen 28
    stAR-related lipid transfer protein 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006645.3NP_006636.2  START domain-containing protein 10

      See identical proteins and their annotated locations for NP_006636.2

      Status: VALIDATED

      Source sequence(s)
      AP002381, AP003065
      Consensus CDS
      CCDS41688.1
      UniProtKB/Swiss-Prot
      O60532, Q9Y365
      UniProtKB/TrEMBL
      B3KTJ1
      Related
      ENSP00000335247.6, ENST00000334805.11
      Conserved Domains (1) summary
      cd08871
      Location:19241
      START_STARD10-like; Lipid-binding START domain of mammalian STARD10 and related proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      72754729..72794047 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      72682966..72722274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)