U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    HSPH1 heat shock protein family H (Hsp110) member 1 [ Homo sapiens (human) ]

    Gene ID: 10808, updated on 7-Apr-2024

    Summary

    Official Symbol
    HSPH1provided by HGNC
    Official Full Name
    heat shock protein family H (Hsp110) member 1provided by HGNC
    Primary source
    HGNC:HGNC:16969
    See related
    Ensembl:ENSG00000120694 MIM:610703; AllianceGenome:HGNC:16969
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HSP105; HSP105A; HSP105B; NY-CO-25
    Summary
    This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]
    Expression
    Broad expression in brain (RPKM 32.5), testis (RPKM 30.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    13q12.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (31134973..31162388, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (30358018..30385432, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (31709110..31736525, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723392 Neighboring gene Sharpr-MPRA regulatory region 1526 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:31664078-31664646 Neighboring gene WD repeat domain 95, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:31735135-31735680 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:31735681-31736226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7551 Neighboring gene uncharacterized LOC105370148 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5240 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5241 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:31783127-31783654 Neighboring gene beta 3-glucosyltransferase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:31876110-31876722 Neighboring gene ankyrin repeat domain 26 pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 is identified to have a physical interaction with heat shock 105kDa/110kDa protein 1 (HSPH1; HSP105) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with heat shock 105kDa/110kDa protein 1 (HSPH1; HSP105) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0201, DKFZp686M05240

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables adenyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables alpha-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endocytic vesicle lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    heat shock protein 105 kDa
    Names
    antigen NY-CO-25
    heat shock 105kDa/110kDa protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053051.1 RefSeqGene

      Range
      6206..33137
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001286503.2NP_001273432.1  heat shock protein 105 kDa isoform 2

      See identical proteins and their annotated locations for NP_001273432.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2, also known as Hsp105beta) is shorter than isoform 1.
      Source sequence(s)
      AB003333, AL137142, BC037553, DB077644
      Consensus CDS
      CCDS66525.1
      UniProtKB/TrEMBL
      B4DF68
      Related
      ENSP00000369768.4, ENST00000380405.7
      Conserved Domains (1) summary
      cd11739
      Location:2384
      HSPH1_NBD; Nucleotide-binding domain of HSPH1
    2. NM_001286504.1NP_001273433.1  heat shock protein 105 kDa isoform 3

      See identical proteins and their annotated locations for NP_001273433.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is longer than isoform 1.
      Source sequence(s)
      AK302430, AL137142, BC037553, DB069199
      Consensus CDS
      CCDS66526.1
      UniProtKB/TrEMBL
      B4DF68
      Related
      ENSP00000487365.1, ENST00000630972.2
      Conserved Domains (1) summary
      cl17037
      Location:39386
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    3. NM_001286505.1NP_001273434.1  heat shock protein 105 kDa isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and contains multiple differences in the coding region, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (4) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK302294, AK302430, AL137142, BC037553, DB069199
      Consensus CDS
      CCDS73559.1
      UniProtKB/TrEMBL
      A0A0A0MSM0, B4DY72
      Related
      ENSP00000396090.3, ENST00000445273.6
      Conserved Domains (2) summary
      cl17037
      Location:39308
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
      cl26953
      Location:39632
      HSP70; Hsp70 protein
    4. NM_001349704.2NP_001336633.1  heat shock protein 105 kDa isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) includes an alternate intron in its 3' coding region and differs in the 3' UTR compared to variant 1. The encoded isoform (5) has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL137142
      UniProtKB/TrEMBL
      B4DF68
      Conserved Domains (1) summary
      cd11739
      Location:2384
      HSPH1_NBD; Nucleotide-binding domain of HSPH1
    5. NM_006644.4NP_006635.2  heat shock protein 105 kDa isoform 1

      See identical proteins and their annotated locations for NP_006635.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1, also known as Hsp105alpha.
      Source sequence(s)
      AL137142, BC037553, CD251908
      Consensus CDS
      CCDS9340.1
      UniProtKB/Swiss-Prot
      B4DYH1, O95739, Q5TBM6, Q5TBM7, Q5TBM8, Q92598, Q9UPC4
      UniProtKB/TrEMBL
      B4DF68
      Related
      ENSP00000318687.5, ENST00000320027.10
      Conserved Domains (1) summary
      cd11739
      Location:2384
      HSPH1_NBD; Nucleotide-binding domain of HSPH1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      31134973..31162388 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020362.3XP_016875851.1  heat shock protein 105 kDa isoform X3

      UniProtKB/TrEMBL
      B4DF68
    2. XM_005266236.3XP_005266293.1  heat shock protein 105 kDa isoform X2

      See identical proteins and their annotated locations for XP_005266293.1

      UniProtKB/TrEMBL
      B4DF68
      Conserved Domains (2) summary
      pfam00012
      Location:39666
      HSP70; Hsp70 protein
      cl17037
      Location:39386
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    3. XM_011534887.4XP_011533189.1  heat shock protein 105 kDa isoform X1

      UniProtKB/TrEMBL
      B4DF68
      Conserved Domains (2) summary
      pfam00012
      Location:39710
      HSP70; Hsp70 protein
      cl17037
      Location:39386
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    4. XM_017020364.3XP_016875853.1  heat shock protein 105 kDa isoform X7

      UniProtKB/TrEMBL
      B4DY72
    5. XM_047430058.1XP_047286014.1  heat shock protein 105 kDa isoform X6

    6. XM_011534888.3XP_011533190.1  heat shock protein 105 kDa isoform X5

      UniProtKB/TrEMBL
      B4DY72
      Conserved Domains (2) summary
      pfam00012
      Location:3630
      HSP70; Hsp70 protein
      cl17037
      Location:2306
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    7. XM_017020363.3XP_016875852.1  heat shock protein 105 kDa isoform X4

      UniProtKB/TrEMBL
      B4DF68

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      30358018..30385432 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374039.1XP_054230014.1  heat shock protein 105 kDa isoform X3

    2. XM_054374038.1XP_054230013.1  heat shock protein 105 kDa isoform X2

    3. XM_054374037.1XP_054230012.1  heat shock protein 105 kDa isoform X1

    4. XM_054374043.1XP_054230018.1  heat shock protein 105 kDa isoform X7

    5. XM_054374042.1XP_054230017.1  heat shock protein 105 kDa isoform X6

    6. XM_054374041.1XP_054230016.1  heat shock protein 105 kDa isoform X5

    7. XM_054374040.1XP_054230015.1  heat shock protein 105 kDa isoform X4