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    Cenpf centromere protein F [ Mus musculus (house mouse) ]

    Gene ID: 108000, updated on 18-Sep-2024

    Summary

    Official Symbol
    Cenpfprovided by MGI
    Official Full Name
    centromere protein Fprovided by MGI
    Primary source
    MGI:MGI:1313302
    See related
    Ensembl:ENSMUSG00000026605 AllianceGenome:MGI:1313302
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CENF; Lek1; PRO1779; mitosin; 6530404A22Rik
    Summary
    Predicted to enable several functions, including dynein complex binding activity; protein C-terminus binding activity; and protein homodimerization activity. Acts upstream of or within regulation of striated muscle tissue development. Located in cytoskeleton and pronucleus. Part of ciliary transition fiber. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and limb. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Stromme syndrome. Orthologous to human CENPF (centromere protein F). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 9.3), liver E14 (RPKM 4.4) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cenpf in Genome Data Viewer
    Location:
    1 H6; 1 95.03 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (189372803..189420302, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (189640606..189688107, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46177 Neighboring gene STARR-seq mESC enhancer starr_03397 Neighboring gene STARR-seq mESC enhancer starr_03398 Neighboring gene STARR-positive B cell enhancer ABC_E3351 Neighboring gene predicted gene, 30088 Neighboring gene STARR-positive B cell enhancer ABC_E802 Neighboring gene STARR-positive B cell enhancer mm9_chr1:191524821-191525121 Neighboring gene STARR-seq mESC enhancer starr_03400 Neighboring gene STARR-seq mESC enhancer starr_03401 Neighboring gene STARR-seq mESC enhancer starr_03402 Neighboring gene protein tyrosine phosphatase, non-receptor type 14 Neighboring gene predicted gene, 51739 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:191627745-191627946 Neighboring gene STARR-seq mESC enhancer starr_03406 Neighboring gene predicted gene, 30280

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables dynein complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in metaphase chromosome alignment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of G2/M transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of striated muscle tissue development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in chromosome, centromeric region IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of ciliary transition fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    part_of outer kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    located_in pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    centromere protein F
    Names
    centromere autoantigen F
    leucine, glutamic acid, lysine family 1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081363.2NP_001074832.2  centromere protein F

      Status: VALIDATED

      Source sequence(s)
      AC140679
      Consensus CDS
      CCDS35820.2
      UniProtKB/TrEMBL
      E9Q3P4, Q155P7
      Related
      ENSMUSP00000129738.2, ENSMUST00000171929.8
      Conserved Domains (5) summary
      COG0419
      Location:9151363
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      TIGR02168
      Location:2901122
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10473
      Location:23132449
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam10481
      Location:1300
      CENP-F_N; Cenp-F N-terminal domain
      pfam10490
      Location:28502896
      CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      189372803..189420302 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497119.4XP_006497182.1  centromere protein F isoform X1

      UniProtKB/TrEMBL
      Q155P7
      Conserved Domains (6) summary
      COG0419
      Location:8431291
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      COG1196
      Location:18652702
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:2181050
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10473
      Location:22412377
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam10481
      Location:1228
      CENP-F_N; Cenp-F N-terminal domain
      pfam10490
      Location:27782824
      CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1