Format

Send to:

Choose Destination
    • Showing Current items.

    Cenpf centromere protein F [ Mus musculus (house mouse) ]

    Gene ID: 108000, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cenpfprovided by MGI
    Official Full Name
    centromere protein Fprovided by MGI
    Primary source
    MGI:MGI:1313302
    See related
    Ensembl:ENSMUSG00000026605
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CENF; Lek1; PRO1779; mitosin; AI325968; 6530404A22Rik
    Expression
    Biased expression in CNS E11.5 (RPKM 9.3), liver E14 (RPKM 4.4) and 10 other tissues See more
    Orthologs

    Genomic context

    See Cenpf in Genome Data Viewer
    Location:
    1 H6; 1 95.03 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (189640606..189688105, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (191464485..191511965, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 46177 Neighboring gene predicted gene, 30088 Neighboring gene protein tyrosine phosphatase, non-receptor type 14 Neighboring gene predicted gene, 30280 Neighboring gene SET and MYND domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    dynein complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    kidney development ISO
    Inferred from Sequence Orthology
    more info
     
    metaphase plate congression ISO
    Inferred from Sequence Orthology
    more info
     
    mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    protein transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of striated muscle tissue development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ventricular system development ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ciliary basal body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ciliary transition fiber IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ciliary transition fiber ISO
    Inferred from Sequence Orthology
    more info
     
    condensed chromosome outer kinetochore ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    NOT kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    midbody ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    pronucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle ISO
    Inferred from Sequence Orthology
    more info
     
    spindle pole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    centromere protein F
    Names
    centromere autoantigen F
    leucine, glutamic acid, lysine family 1 protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081363.2NP_001074832.2  centromere protein F

      Status: VALIDATED

      Source sequence(s)
      AC140679
      Consensus CDS
      CCDS35820.2
      UniProtKB/TrEMBL
      E9Q3P4
      Related
      ENSMUSP00000129738.1, ENSMUST00000171929.7
      Conserved Domains (5) summary
      COG0419
      Location:9151363
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      TIGR02168
      Location:2901122
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10473
      Location:23132449
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam10481
      Location:1300
      CENP-F_N; Cenp-F N-terminal domain
      pfam10490
      Location:28502896
      CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      189640606..189688105 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497119.2XP_006497182.1  centromere protein F isoform X1

      Conserved Domains (5) summary
      COG0419
      Location:8431291
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      TIGR02168
      Location:2181050
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10473
      Location:22412377
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam10481
      Location:1228
      CENP-F_N; Cenp-F N-terminal domain
      pfam10490
      Location:27782824
      CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1
    2. XM_017320925.1XP_017176414.1  centromere protein F isoform X1

      Conserved Domains (5) summary
      COG0419
      Location:8431291
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      TIGR02168
      Location:2181050
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam10473
      Location:22412377
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
      pfam10481
      Location:1228
      CENP-F_N; Cenp-F N-terminal domain
      pfam10490
      Location:27782824
      CENP-F_C_Rb_bdg; Rb-binding domain of kinetochore protein Cenp-F/LEK1
    Support Center