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    Ddb2 damage specific DNA binding protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 107986, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ddb2provided by MGI
    Official Full Name
    damage specific DNA binding protein 2provided by MGI
    Primary source
    MGI:MGI:1355314
    See related
    Ensembl:ENSMUSG00000002109
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p4; 2610043A19Rik
    Expression
    Ubiquitous expression in mammary gland adult (RPKM 18.6), spleen adult (RPKM 15.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ddb2 in Genome Data Viewer
    Location:
    2; 2 E1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (91041924..91067465, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (91211545..91237132, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (91051736..91077223, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene MAP-kinase activating death domain Neighboring gene nuclear receptor subfamily 1, group H, member 3 Neighboring gene predicted gene, 23390 Neighboring gene acid phosphatase 2, lysosomal Neighboring gene RIKEN cDNA A330069E16 gene Neighboring gene predicted gene, 31054

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC117576

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to damaged DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in UV-damage excision repair ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within cellular response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in histone H2A monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within pyrimidine dimer repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to UV IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of Cul4B-RING E3 ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    DNA damage-binding protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362705.1NP_001349634.1  DNA damage-binding protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK158770, BC099410, CK627126
      Conserved Domains (1) summary
      sd00039
      Location:114151
      7WD40; WD40 repeat [structural motif]
    2. NM_028119.5NP_082395.2  DNA damage-binding protein 2 isoform 1

      See identical proteins and their annotated locations for NP_082395.2

      Status: VALIDATED

      Source sequence(s)
      BC058589, BU515611, CK627126
      Consensus CDS
      CCDS16428.1
      UniProtKB/Swiss-Prot
      Q99J79
      Related
      ENSMUSP00000028696.5, ENSMUST00000028696.5
      Conserved Domains (3) summary
      COG2319
      Location:58431
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:115154
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:115419
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      91041924..91067465 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157313.1XP_036013206.1  DNA damage-binding protein 2 isoform X1

      Conserved Domains (2) summary
      sd00039
      Location:115154
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:115293
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. XR_374383.4 RNA Sequence

    2. XR_001780206.2 RNA Sequence

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